Výsledky vyhledávání - "Gary Robert Kelm"

Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine

Autor: Jim Li, Patricia Sue Raleigh, Gary Robert Kelm, Donald Lynn Bissett, Tomohiro Hakozaki, Kukizo Miyamoto, Larry Richard Robinson

Publikováno v: Journal of Cosmetic Dermatology. 6:20-26

Glucosamine has been reported to inhibit melanin production in melanocyte culture. It thus has a potential to reduce hyperpigmentation via topical use. Due to stability limitations of glucosamine, we chose to clinically evaluate the stable derivative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759115e8d8c17f025cc87487c4b6b489
https://doi.org/10.1111/j.1473-2165.2007.00295.x

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Suppression of food intake by GI fatty acid infusions: roles of celiac vagal afferents and cholecystokinin

Autor: Gary Robert Kelm, James E. Cox, Stephen T. Meller, Alan Randich

Publikováno v: Physiology & Behavior. 82:27-33

We have found that jejunal infusions of long-chain fatty acids, linoleic acid (LA) and oleic acid (OA), and gastric infusions of a fatty acid ethyl ester, ethyl oleate (EO), produce long-lasting suppression of total caloric intake. This effect is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429c3cfd32534f5ef9927aa1952ec10c
https://doi.org/10.1016/j.physbeh.2004.04.022

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The safety of the use of ethyl oleate in food is supported by metabolism data in rats and clinical safety data in humans

Autor: Roy M. Kulick, Sheela PaiBir, Gary Robert Kelm, Timothy K. Balm, Robert C Bookstaff, John V Murray, Satinder Singh Bharaj

Publikováno v: Regulatory Toxicology and Pharmacology. 37:133-148

The absorption, distribution, and excretion of radiolabeled ethyl oleate (EO) was studied in Sprague-Dawley rats after a single, peroral dose of 1.7 or 3.4 g/kg body weight and was compared with a radiolabeled triacylglycerol (TG) containing only ole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4cfbfab34d22bd12bfd689266ff5fb
https://doi.org/10.1016/s0273-2300(02)00043-0

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Responses of hepatic and celiac vagal afferents to intraportal mercaptoacetate in rats fed a high-fat or low-fat diet

Autor: James E. Cox, Stephen T. Meller, Alan Randich, D. Seth Spraggins, Gary Robert Kelm

Publikováno v: Neuroreport. 13:675-679

Responses of either hepatic or celiac vagal afferents to intraportal hepatic vein administration of 2-mercaptoacetate (MA) were examined in rats maintained on either a high-fat or low-fat diet. Afferent activity in both hepatic and celiac vagal affer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c135a720256a46cc23daf960565a4024
https://doi.org/10.1097/00001756-200204160-00028

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[Untitled]

Autor: Fritz Sörgel, Jörn Lötsch, Martina Kinzig-Schippers, Irmgard Tegeder, Stephen T. Meller, Gerd Geisslinger, Gary Robert Kelm

Publikováno v: Pharmaceutical Research. 18:980-986

Purpose. To assess whether topical ketoprofen, which has been reported to provide analgesic effects in clinical studies, reaches predictable tissue concentrations high enough to account for the reported analgesia. Intramuscular ketoprofen was used as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72d7d102380d7ba9b35b69b2cc3f2f81
https://doi.org/10.1023/a:1010940428479

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Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions

Autor: Satinder Singh Bharaj, Stephen T. Meller, Alan Randich, William J. Tyler, James E. Cox, Ronald J. Jandacek, Gary Robert Kelm

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 278:R604-R610

Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83abc0eb58360eb21cbf28782bf5c094
https://doi.org/10.1152/ajpregu.2000.278.3.r604

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Evaluation of Ketorolac Concentrations in Plasma and Gingival Crevicular Fluid following Topical Treatment with Oral Rinses and Dentifrices

Autor: Gary Robert Kelm, N.V. Bapat, Steven Offenbacher, William Buchanan, J.G. Collins, Michael P. Meredith, S.M. Mankodi, Kenneth R. Wehmeyer, Douglas Joseph Dobrozsi, Matthew Joseph Doyle, Thomas H. Eichhold

Publikováno v: Journal of Pharmaceutical Sciences. 85:842-847

Two clinical studies were conducted to determine the relative amounts of ketorolac detectable locally in the gingival crevicular fluid (GCF) and systemically in plasma after oral, topical drug administration. The rinse study compared topical administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9449d0370815832d65914475a9f5b9
https://doi.org/10.1021/js9505253

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Development and application of a gas chromatographic/mass spectrometric/mass spectrometric method for the determination of 5-methoxyflavone in rat and dog plasma

Autor: Debra L. Kuhlenbeck, Jorge Villanueva Penafiel, Timothy R. Baker, Gary Robert Kelm, Kenneth R. Wehmeyer, Douglas Joseph Dobrozsi, Linda J. Tulich

Publikováno v: Journal of Mass Spectrometry. 30:438-445

A gas chromatographic/mass spectrometric/mass spectrometric method was developed for the determination of 5-methoxyflavone in plasma. Optimized detection schemes for 5-methoxyflavone readily allow a limit of quantification of 1 ng ml-' in rat or dog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24ad0617a90f55129d5e5ff865d827b3
https://doi.org/10.1002/jms.1190300307

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[Untitled]

Autor: Michael P. Meredith, Charles A. Cruze, Gary Robert Kelm

Publikováno v: Pharmaceutical Research. 12:895-901

Purpose. Retrospective application of allometric scaling techniques to tebufelone, a nonsteroidal antiinflammatory agent, in order to better understand the systemic exposure relationships between the doses administered to the species used in toxicolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aaf9f8369030751c695edda6f50cb24
https://doi.org/10.1023/a:1016273306956

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