Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Gary R Mirams"'
Autor:
Thomas Grandits, Christoph M Augustin, Gundolf Haase, Norbert Jost, Gary R Mirams, Steven A Niederer, Gernot Plank, András Varró, László Virág, Alexander Jung
Publikováno v:
eLife, Vol 12 (2024)
Computer models of the human ventricular cardiomyocyte action potential (AP) have reached a level of detail and maturity that has led to an increasing number of applications in the pharmaceutical sector. However, interfacing the models with experimen
Externí odkaz:
https://doaj.org/article/e09721e69670414b959a7fb39806768a
Autor:
Gary R Mirams, Michael Clerx, Maurice Hendrix, Sarah M Keating, Asif U Tamuri, Jonathan Cooper, Ross H Johnstone
Publikováno v:
Wellcome Open Research, Vol 6 (2022)
Hundreds of different mathematical models have been proposed for describing electrophysiology of various cell types. These models are quite complex (nonlinear systems of typically tens of ODEs and sometimes hundreds of parameters) and software packag
Externí odkaz:
https://doaj.org/article/f89145659bf640afac066e32b0abcd8b
Autor:
Gary R Mirams, Michael Clerx, Maurice Hendrix, Sarah M Keating, Asif U Tamuri, Jonathan Cooper, Ross H Johnstone
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Hundreds of different mathematical models have been proposed for describing electrophysiology of various cell types. These models are quite complex (nonlinear systems of typically tens of ODEs and sometimes hundreds of parameters) and software packag
Externí odkaz:
https://doaj.org/article/885889b6adc44bf385111c7d46c62c19
Publikováno v:
Wellcome Open Research, Vol 1 (2017)
Dose-response (or ‘concentration-effect’) relationships commonly occur in biological and pharmacological systems and are well characterised by Hill curves. These curves are described by an equation with two parameters: the inhibitory concentratio
Externí odkaz:
https://doaj.org/article/923737ba9422490ab00ef4de13774341
Autor:
James M Osborne, Miguel O Bernabeu, Maria Bruna, Ben Calderhead, Jonathan Cooper, Neil Dalchau, Sara-Jane Dunn, Alexander G Fletcher, Robin Freeman, Derek Groen, Bernhard Knapp, Greg J McInerny, Gary R Mirams, Joe Pitt-Francis, Biswa Sengupta, David W Wright, Christian A Yates, David J Gavaghan, Stephen Emmott, Charlotte Deane
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003506 (2014)
Externí odkaz:
https://doaj.org/article/7e501827514d4598aa43b6895de6034c
Autor:
John Walmsley, Jose F Rodriguez, Gary R Mirams, Kevin Burrage, Igor R Efimov, Blanca Rodriguez
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56359 (2013)
Differences in mRNA expression levels have been observed in failing versus non-failing human hearts for several membrane channel proteins and accessory subunits. These differences may play a causal role in electrophysiological changes observed in hum
Externí odkaz:
https://doaj.org/article/0e9bdc19275a4f23a27c978f362712fd
Autor:
Gary R Mirams, Christopher J Arthurs, Miguel O Bernabeu, Rafel Bordas, Jonathan Cooper, Alberto Corrias, Yohan Davit, Sara-Jane Dunn, Alexander G Fletcher, Daniel G Harvey, Megan E Marsh, James M Osborne, Pras Pathmanathan, Joe Pitt-Francis, James Southern, Nejib Zemzemi, David J Gavaghan
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1002970 (2013)
Chaste - Cancer, Heart And Soft Tissue Environment - is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology. Code development has been driven by two initial applications: cardiac ele
Externí odkaz:
https://doaj.org/article/8531a43edb6e47d7b0e7c4580474c6b9
Background and PurposeDrug-induced reduction of the rapid delayed rectifier potassium current carried by the human Ether-à-go-go-Related Gene (hERG) channel is associated with increased risk of arrhythmias. Recent updates to drug safety regulatory g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5a81c0f116d3d4bb8831d9d67347eaf
https://doi.org/10.1101/2023.03.14.532553
https://doi.org/10.1101/2023.03.14.532553
Autor:
Thamali Ayagama, Philip D Charles, Samuel J Bose, Barry Boland, David A Priestman, Daniel Aston, Georgina Berridge, Roman Fisher, Adam P Cribbs, Qianqian Song, Gary R Mirams, Lisa Heather, Antony Galione, Neil Herring, Ulrich Schotten, Rebecca A Capel, Frances M Platt, Holger Krame, Sander Verheule, Rebecca AB Burton
SummaryEndolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL help facilitate elimination of damaged membrane and cytosolic proteins, protein aggregates, membranous organelles and also play an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7d6c55db8b271c1c4a8ef5f88e1cd3
https://doi.org/10.1101/2023.03.10.532119
https://doi.org/10.1101/2023.03.10.532119
Autor:
'Yann-Stanislas H.M. Barral, Liudmila Polonchuk, Gary R. Mirams, Michael Clerx, Guy Page, Katrina Sweat, Najah Abi-Gerges, Ken Wang, David J. Gavaghan\\'
Publikováno v:
Computing in Cardiology Conference (CinC).