Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Gary Peltz"'
Autor:
Jared R. Bagley, Yalun Tan, Wan Zhu, Zhuanfen Cheng, Saori Takeda, Zhouqing Fang, Ahmed Arslan, Meiyue Wang, Yuan Guan, Lihua Jiang, Ruiqi Jian, Feng Gu, Isabel Parada, David Prince, J. David Jentsch, Gary Peltz
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Genetic variation accounts for much of the risk for developing a substance use disorder, but the underlying genetic factors and their genetic effector mechanisms are mostly unknown. Inbred mouse strains exhibit substantial and heritable diff
Externí odkaz:
https://doaj.org/article/91c772b59b88411a818dba8a2954c106
Autor:
Yuan Guan, Dan Xu, Phillip M. Garfin, Ursula Ehmer, Melissa Hurwitz, Greg Enns, Sara Michie, Manhong Wu, Ming Zheng, Toshihiko Nishimura, Julien Sage, Gary Peltz
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Externí odkaz:
https://doaj.org/article/c862f874a6f64c1796444bc6e73fbfe5
Autor:
Ahmed Arslan, Zhuoqing Fang, Meiyue Wang, Yalun Tan, Zhuanfen Cheng, Xinyu Chen, Yuan Guan, Laura J. Pisani, Boyoung Yoo, Gill Bejerano, Gary Peltz
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background ‘Long read’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases. Therefore, we investigated whether long read sequencing could facilitate genetic analy
Externí odkaz:
https://doaj.org/article/cf8ac40aaf94412b931c7e8cdb7ccdc7
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 2, Pp 216-223 (2023)
Abstract Administration of a widely used 5‐hydroxytryptamine receptor (5HT3AR) antagonist (ondansetron) potently inhibited the development of experimentally induced opioid dependence and withdrawal responses in mice and humans. However, in several
Externí odkaz:
https://doaj.org/article/878793b4463b4d988722f3c647db24b7
Autor:
Yuan Guan, Annika Enejder, Meiyue Wang, Zhuoqing Fang, Lu Cui, Shih-Yu Chen, Jingxiao Wang, Yalun Tan, Manhong Wu, Xinyu Chen, Patrik K. Johansson, Issra Osman, Koshi Kunimoto, Pierre Russo, Sarah C. Heilshorn, Gary Peltz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Autosomal recessive polycystic kidney disease (ARPKD) is a genetic disorder which is associated with kidney and liver pathology, including liver fibrosis. Here the authors develop and characterize human liver organoids with a ARPKD mutation, and find
Externí odkaz:
https://doaj.org/article/a0a7c814994743da9ab4dcaf12e47001
Autor:
Min Ren, Majid Kazemian, Ming Zheng, JianPing He, Peng Li, Jangsuk Oh, Wei Liao, Jessica Li, Jonathan Rajaseelan, Brian L. Kelsall, Gary Peltz, Warren J. Leonard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Heterogeneous helper T (Th) cell responses contribute to differential susceptibility to immunological disorders. Here the authors perform haplotype-based computational screens of 16 inbred mouse strains to identify a transcription factor, p73, as an
Externí odkaz:
https://doaj.org/article/ffad1db4d4b34ec79a555bbe08c7c711
Autor:
Gary Peltz, Yalun Tan
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2022)
The tremendous public health problem created by substance use disorders (SUDs) presents a major opportunity for mouse genetics. Inbred mouse strains exhibit substantial and heritable differences in their responses to drugs of abuse (DOA) and in many
Externí odkaz:
https://doaj.org/article/23de656c3ba74267af035e9a0b919501
Autor:
Sean M. Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R. Seemiller, Molly A. Bogue, Stephen C. Grubb, Gary Peltz, Thomas J. Gould
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Learning is a critical behavioral process that is influenced by many neurobiological systems. We and others have reported that acetylcholinergic signaling plays a vital role in learning capabilities, and it is especially important for contextual fear
Externí odkaz:
https://doaj.org/article/5286f4c9da6a4565a2f21b075fb95662
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The ability to use genome-wide association studies (GWAS) for genetic discovery depends upon our ability to distinguish true causative from false positive association signals. Population structure (PS) has been shown to cause false positive signals i
Externí odkaz:
https://doaj.org/article/1970ef5afe9b4628b880d74f2a4cd8c0
Autor:
Daniel R. Hunt, Katarina C. Klett, Shamik Mascharak, Huiyuan Wang, Diana Gong, Junzhe Lou, Xingnan Li, Pamela C. Cai, Riley A. Suhar, Julia Y. Co, Bauer L. LeSavage, Abbygail A. Foster, Yuan Guan, Manuel R. Amieva, Gary Peltz, Yan Xia, Calvin J. Kuo, Sarah C. Heilshorn
Publikováno v:
Advanced Science, Vol 8, Iss 10, Pp n/a-n/a (2021)
Abstract Human intestinal organoids from primary human tissues have the potential to revolutionize personalized medicine and preclinical gastrointestinal disease models. A tunable, fully defined, designer matrix, termed hyaluronan elastin‐like prot
Externí odkaz:
https://doaj.org/article/51791a5732c64f4090690b8d74723f7c