Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Gary P.H. Ho"'
Autor:
Tracy L. Young-Pearse, Ulf Dettmer, Thibaut Imberdis, Elizabeth Terry-Kantor, Dennis J. Selkoe, Oren A. Levy, Tae-Eun Kim, Saranna Fanning, Gary P.H. Ho, Georgia L. Stirtz, Joseph Negri, Nagendran Ramalingam
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Misfolding and accumulation of the protein α-synuclein (αS) inside nerve cells characterize Parkinson’s disease (PD) and related brain diseases, for which no disease-modifying therapies exist. Robust cell models are needed that recap
Autor:
Elizabeth Terry-Kantor, Zachary M LaVoie, Thibaut Imberdis, Arati Tripathi, Dennis J. Selkoe, Gary P.H. Ho, Ulf Dettmer, Saranna Fanning, Nagendran Ramalingam
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5193, p 5193 (2020)
Volume 21
Issue 15
International Journal of Molecular Sciences, Vol 21, Iss 5193, p 5193 (2020)
Genetic and biochemical evidence attributes neuronal loss in Parkinson&rsquo
s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein &alpha
synuclein (&alpha
S). There is no consensus on how &alpha
S exer
s disease (PD) and related brain diseases to dyshomeostasis of the 14 kDa protein &alpha
synuclein (&alpha
S). There is no consensus on how &alpha
S exer
Autor:
Thibaut Imberdis, Frank Soldner, Michel Becuwe, Sepp D. Kohlwein, Yelena Freyzon, Gary P.H. Ho, Aftabul Haque, Tobias C. Walther, Clary B. Clish, Elizabeth Terry-Kantor, Dennis J. Selkoe, Saranna Fanning, Gregory A. Newby, Daniel Termine, Tallie Noble, Nagendran Ramalingam, M. Inmaculada Barrasa, Robert V. Farese, Michael A. Welte, Susan Lindquist, Yali Lou, Jackson Sandoe, Tae-Eun Kim, Harald F. Hofbauer, Silke Nuber, David Pincus, Dirk Landgraf, Rudolf Jaenisch, Supriya Srinivasan, Ulf Dettmer, Valeriya Baru
Publikováno v:
PMC
In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995be04b05c6e841478eda306d3ad6bc
https://hdl.handle.net/1721.1/125128
https://hdl.handle.net/1721.1/125128
Publikováno v:
Restless Legs Syndrome/Willis Ekbom Disease ISBN: 9781493967759
In this chapter, we discuss the various forms of impulsive and compulsive behaviors that may occur as a consequence of RLS treatment. These behaviors share certain clinical and pathophysiological features with PD patients on similar medications, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9cee07c29aeadd79cc2293f60ed9a3e
https://doi.org/10.1007/978-1-4939-6777-3_16
https://doi.org/10.1007/978-1-4939-6777-3_16
Autor:
Solomon H. Snyder, Gary P.H. Ho, Hyo Jung Kim, Seyun Kim, Hyeonjin Choi, Jing Xu, Jae Woo Kim, Jiyoung Y. Cha, Feng Rao, Daham Kim, Bindu D. Paul, Jung Hwan Yu, Yoo Jeong Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 110:20575-20580
Significance Glucocorticoids are well known to play a major role in obesity, but underlying mechanisms have been obscure. We demonstrate that the small G protein Dexras1, first identified based on its dramatic induction by glucocorticoids, mediates a
Publikováno v:
Neurology. 86(10)
A 58-year-old woman developed painless visual loss in her left eye over several days. She described the vision in her left eye as “similar to looking through a dirty screen door.” She denied double vision and eye pain but reported frontal throbbi
Autor:
Joseph A. Gogos, Jun Mukai, Balakrishnan Selvakumar, Lynda D. Hester, Yuxuan Wang, Solomon H. Snyder, Gary P.H. Ho
Publikováno v:
Neuron. 71(1):131-141
SummaryPSD-95, a principal scaffolding component of the postsynaptic density, is targeted to synapses by palmitoylation, where it couples NMDA receptor stimulation to production of nitric oxide (NO) by neuronal nitric oxide synthase (nNOS). Here, we
Publikováno v:
Molecular and Cellular Biology. 26:7005-7015
The Fanconi anemia (FA) pathway is a DNA damage-activated signaling pathway which regulates cellular resistance to DNA cross-linking agents. Cloned FA genes and proteins cooperate in this pathway, and monoubiquitination of FANCD2 is a critical downst
Publikováno v:
Carcinogenesis. 27:883-892
The cellular response to DNA damage is composed of cell cycle checkpoint and DNA repair mechanisms that serve to ensure proper replication of the genome prior to cell division. The function of the DNA damage response during DNA replication in S-phase
Autor:
Roxanne K. Barrow, Jeffrey T. Ehmsen, Asif K. Mustafa, Solomon H. Snyder, Gary P.H. Ho, L. Mario Amzel, Balakrishnan Selvakumar, Manish Kumar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(8)
Serine racemase (SR) generates d -serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S -nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflect