Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gary P. Swain"'
Autor:
Ernesto R. Bongarzone, Charles A. Assenmacher, G. Diane Shelton, Keiko Miyadera, Gary P. Swain, Charles H. Vite, Xuntian Jiang, Erik Lykken, Duc Nguyen, Jill Pesayco Salvador, Jessica H. Bagel, Patricia O'Donnell, Arielle Ostrager, Steven J. Gray, Rebecka S. Hess, Mark S. Sands, Allison M. Bradbury, Daniel S. Ory, Ian J. Hendricks
Publikováno v:
J Clin Invest
Globoid cell leukodystrophy (GLD; Krabbe disease) is a progressive, incurable neurodegenerative disease caused by deficient activity of the hydrolytic enzyme galactosylceramidase (GALC). The ensuing cytotoxic accumulation of psychosine results in dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ce5b5cc6bef1edb4b2daa4b39f4091
https://doi.org/10.1172/jci133953
https://doi.org/10.1172/jci133953
Autor:
Alfred Lordi, Gary P. Swain, Nicole Kasica, Charles H. Vite, Eric Solon, Susan Stellar, Mark L. Kao, Jessica H. Bagel, Brittney L. Gurda
Publikováno v:
Journal of Inherited Metabolic Disease
2‐Hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) is an experimental therapy for Niemann‐Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, reduced Purkinje cell death, and increased lifespan in npc1−/− mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876bae85ee541e28ec78b27819832957
https://doi.org/10.1002/jimd.12189
https://doi.org/10.1002/jimd.12189
Autor:
Molly E. Church, Charles H. Vite, Edward G. Stopa, Melissa D. Sánchez, Gary P. Swain, Guadalupe Ceja, Megan McGeehan, Charles-Antoine Assenmacher, Amit Bar-Or, Priscilla Farias, Jorge I. Alvarez, Miles C Miller
Publikováno v:
J Immunol
Multiple sclerosis (MS) is an idiopathic demyelinating disease in which meningeal inflammation correlates with accelerated disease progression. The study of meningeal inflammation in MS has been limited because of constrained access to MS brain/spina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a848dfad8735ffc2cc4947d321c6c8
https://pubmed.ncbi.nlm.nih.gov/34162727
https://pubmed.ncbi.nlm.nih.gov/34162727
Autor:
Maria Prociuk, Ernesto R. Bongarzone, Becky K. Brisson, Allison M. Bradbury, Caitlin A. Fitzgerald, Mohammed A Rafi, Jill Pesayco Salvador, Michael S. Marshall, Daniel S. Ory, G. Diane Shelton, Gary P. Swain, Jessica H. Bagel, David A. Wenger, Xuntain Jiang, Charles H. Vite, Patricia O'Donnell
Publikováno v:
Human Gene Therapy. 29:785-801
Globoid cell leukodystrophy (GLD), or Krabbe disease, is an inherited, neurologic disorder that results from deficiency of a lysosomal enzyme, galactosylceramidase. Most commonly, deficits of galactosylceramidase result in widespread central and peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37734364d5ca067c4325a156e8031633
https://doi.org/10.1089/hum.2017.151
https://doi.org/10.1089/hum.2017.151
Autor:
Peter J. Hand, Samantha J. Fisher, Jessica H. Bagel, Gary P. Swain, Andrew P. Lieberman, Brittney L. Gurda, Charles H. Vite, Mark L. Schultz
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 77:229-245
The feline model of Niemann-Pick disease, type C1 (NPC1) recapitulates the clinical, neuropathological, and biochemical abnormalities present in children with NPC1. The hallmarks of disease are the lysosomal storage of unesterified cholesterol and mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6b477417dba31d0b4b6514ceac9db9
https://doi.org/10.1093/jnen/nlx119
https://doi.org/10.1093/jnen/nlx119
Autor:
Kyle G. Braund, Charles H. Vite, Patricia O'Donnell, Caitlin A. Fitzgerald, Gary P. Swain, Xuntian Jiang, Jessica H. Bagel, Maria Prociuk, Allison M. Bradbury, Daniel S. Ory
Publikováno v:
Journal of Neuroscience Research. 94:1007-1017
Globoid cell leukodystrophy (GLD), or Krabbe's disease, is a debilitating and always fatal pediatric neurodegenerative disease caused by a mutation in the gene encoding the hydrolytic enzyme galactosylceramidase (GALC). In the absence of GALC, progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8360057b275477dd91c02a1ec449401
https://doi.org/10.1002/jnr.23838
https://doi.org/10.1002/jnr.23838
Autor:
Forbes D. Porter, Gary P. Swain, Nicole Y. Farhat, Kenneth J. Drobatz, Wenge Ding, Maria Prociuk, Christopher A. Wassif, Jessica H Bagel, Charles H. Vite, Brittney L. Gurda, Alan T. Remaley, Patricia O'Donnell, Maureen Sampson, Allison M. Bradbury
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 358:254-261
Niemann-Pick type C (NPC) 1 disease is a rare, inherited, neurodegenerative disease. Clear evidence of the therapeutic efficacy of 2-hydroxypropyl-β-cyclodextrin (HPβCD) in animal models resulted in the initiation of a phase I/IIa clinical trial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1c392fa6960ca5bb9f4ce2d059b23e
https://doi.org/10.1124/jpet.116.232975
https://doi.org/10.1124/jpet.116.232975
Publikováno v:
Journal of Comparative Neurology. 522:1316-1332
After spinal cord transection, lampreys recover functionally and axons regenerate. It is not known whether this is accompanied by neurogenesis. Previous studies suggested a baseline level of nonneuronal cell proliferation in the spinal cord and rhomb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79dfcd70465ad7e02b94f42792afba38
https://doi.org/10.1002/cne.23485
https://doi.org/10.1002/cne.23485
Autor:
Jessica H. Bagel, Mark E. Haskins, Gary P. Swain, Maria Prociuk, K. Berger, Mark S. Sands, Patty O'Donnell, Kenneth J. Drobatz, Brittney L. Gurda, Charles H. Vite
Publikováno v:
Gene Therapy
Canine models have many advantages for evaluating therapy of human central nervous system (CNS) diseases. In contrast to nonhuman primate models, naturally occurring canine CNS diseases are common. In contrast to murine models, the dog's lifespan is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bead6ba5a67414ca9393ae04842f044
https://doi.org/10.1038/gt.2013.54
https://doi.org/10.1038/gt.2013.54
Autor:
Allison M, Bradbury, Jessica H, Bagel, Xuntian, Jiang, Gary P, Swain, Maria L, Prociuk, Caitlin A, Fitzgerald, Patricia A, O'Donnell, Kyle G, Braund, Daniel S, Ory, Charles H, Vite
Publikováno v:
Journal of neuroscience research. 94(11)
Globoid cell leukodystrophy (GLD), or Krabbe's disease, is a debilitating and always fatal pediatric neurodegenerative disease caused by a mutation in the gene encoding the hydrolytic enzyme galactosylceramidase (GALC). In the absence of GALC, progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf14ad614137090922f6f3eff5d7bee3
https://pubmed.ncbi.nlm.nih.gov/27638585
https://pubmed.ncbi.nlm.nih.gov/27638585