Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Gary P. Moss"'
Autor:
Mark Hewitt, Yi Sun, Simon Wilkinson, Gary P. Moss, Roderick Adams, Darren R. Gullick, Neil Davey
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:873-888
Objectives The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation. Methods A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7922f6c2dae32a34b2c7f9ee4519303
https://doi.org/10.1111/jphp.13263
https://doi.org/10.1111/jphp.13263
Publikováno v:
Journal of Pharmacy and Pharmacology. 72:197-208
Objectives The aim of this study was to use Gaussian process regression (GPR) methods to quantify the effect of experimental temperature (Texp) and choice of diffusion cell on model quality and performance. Methods Data were collated from the literat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157bac3e496c40d99dd28f9c6c4502e0
https://doi.org/10.1111/jphp.13203
https://doi.org/10.1111/jphp.13203
Chlorhexidine digluconate (CHG) is a cationic bisbiguanide used in the UK as the first-line skin antiseptic prior to surgery in the UK due to its favourable efficacy and safety profile, high affinity for skin binding and minimal reports of resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02adfe4ee26c1e08a113c79062e1b176
Autor:
Yi, Sun, Mark, Hewitt, Simon C, Wilkinson, Neil, Davey, Roderick G, Adams, Darren R, Gullick, Gary P, Moss
Publikováno v:
The Journal of pharmacy and pharmacologyReferences. 72(7)
The current study aims to determine the effect of physicochemical descriptor selection on models of polydimethylsiloxane permeation.A total of 2942 descriptors were calculated for a data set of 77 chemicals. Data were processed to remove redundancy,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db1fcbc9cda877690f4edf882939ed3e
https://pubmed.ncbi.nlm.nih.gov/32246470
https://pubmed.ncbi.nlm.nih.gov/32246470
usc The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823d988d3c154ea0305ebfdbdc77d4e7
Objectives The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters. Methods Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evolutionary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd2a7f64c5f7ad686e7d33df691244f
Publikováno v:
Journal of Pharmacy and Pharmacology. 68:170-184
Objectives Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e7a65ce97e6d3a0924c97a7a4826c3
https://doi.org/10.1111/jphp.12508
https://doi.org/10.1111/jphp.12508
Publikováno v:
SAR and QSAR in Environmental Research. 26:181-204
Machine learning (ML) methods have been applied to the analysis of a range of biological systems. This paper reviews the application of these methods to the problem domain of skin permeability and addresses critically some of the key issues. Specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0a98cf80d6619937298109903ec09a
https://doi.org/10.1080/1062936x.2015.1018941
https://doi.org/10.1080/1062936x.2015.1018941
Publikováno v:
International Journal of Cosmetic Science. 37:141-163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aaa16048483adeda0489d5dec7336f1
https://doi.org/10.1111/ics.12196
https://doi.org/10.1111/ics.12196
Skin penetration and localisation of chlorhexidine digluconate (CHG) within the skin have been investigated in order to better understand and optimise the delivery using a nano polymeric delivery system of this topically-applied antimicrobial drug. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57913358c9fd8f0119049a4511957fc1