Binding of Dipeptides to Fatty Acid Membranes Explains Their Colocalization in Protocells, but Does Not Select for Them Relative to Unjoined Amino Acids

Autor: Zachary R. Cohen, Adrienne Roehrich, Roy A. Black, Gary P. Drobny, Sarah L. Keller, Mengjun Xue

Publikováno v: J Phys Chem B

Dipeptides, which consist of two amino acids joined by a peptide bond, have been shown to have catalytic function. This observation leads to fundamental questions relevant to the origins of life. How could peptides have become co-localized with the f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3054b4c04410fbf746c5923242660bd
https://europepmc.org/articles/PMC8323988/

Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes

Autor: Helen E Litz, Mengjun Xue, Zachary R. Cohen, Roy A. Black, Sarah L. Keller, Moshe T. Gordon, James A. Williams, Gary P. Drobny, Caitlin E. Cornell, Kelly K. Lee, Alexander Mileant, Andrew Ramsay

Publikováno v: Proceedings of the National Academy of Sciences. 116:17239-17244

The membranes of the first protocells on the early Earth were likely self-assembled from fatty acids. A major challenge in understanding how protocells could have arisen and withstood changes in their environment is that fatty acid membranes are unst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c726a9fad8f717b0fa5a1017c3bfb15
https://doi.org/10.1073/pnas.1900275116

Molecular recognition and specificity of biomolecules to titanium dioxide from molecular dynamics simulations

Autor: Janani Sampath, Rachel N. Gebhart, Jim Pfaendtner, Gary P. Drobny, Andrew Kullman

Publikováno v: npj Computational Materials, Vol 6, Iss 1, Pp 1-8 (2020)

Titania (TiO2) is used extensively in biomedical applications; efforts to boost the biocompatibility of TiO2 include coating it with the titania binding hexamer, RKLPDA. To understand the binding mechanism of this peptide, we employ molecular dynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fa98da36808cc9528572db334e0e44
https://doi.org/10.1038/s41524-020-0288-7

Ultraslow Domain Motions in HIV-1 TAR RNA Revealed by Solid-State Deuterium NMR

Autor: Gabriele Varani, Gary P. Drobny, Wei Huang, Prashant S. Emani

Publikováno v: The Journal of Physical Chemistry B. 121:110-117

Intrinsic motions may allow HIV-1 transactivation response (TAR) RNA to change its conformation to form a functional complex with the Tat protein, which is essential for viral replication. Understanding the dynamic properties of TAR necessitates dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448bca3e755ca8bf47be7ceb5aa62793
https://doi.org/10.1021/acs.jpcb.6b11041

Solid-State NMR and MD Study of the Structure of the Statherin Mutant SNa15 on Mineral Surfaces

Autor: Massimiliano Bonomi, Arushi Prakash, Gary P. Drobny, Janani Sampath, Erika L. Buckle, Jim Pfaendtner

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2019, 141 (5), pp.1998-2011. ⟨10.1021/jacs.8b10990⟩
Journal of the American Chemical Society, 2019, 141 (5), pp.1998-2011. ⟨10.1021/jacs.8b10990⟩

International audience; Elucidation of the structure and interactions of proteins at native mineral interfaces is key to understanding how biological systems regulate the formation of hard tissue structures. In addition, understanding how these same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f943583192901c36445ae70e9cd503
https://hal.archives-ouvertes.fr/hal-03135860/file/nihms-1052976.pdf