Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gary P Kirschenheuter"'
Autor:
Danny P. C. McGee, Colleen R. Siedem, Yansheng Zhai, Alecia Settle, Chandra Vargeese, Gary P. Kirschenheuter, Wolfgang Pieken
Publikováno v:
Nucleosides and Nucleotides. 14:1329-1339
The synthesis of 2′-amino-2′-deoxypyrimidine 5′-triphosphates is described. The 2′-amino-2′-deoxyuridine 5′-triphosphate is obtained from uridine in four steps with 25% overall yield. The 2′-amino-2′-deoxycytidine 5′-triphosphate is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::025d56e5f0b68015d2cd29cdb86ecb27
https://doi.org/10.1080/15257779508010694
https://doi.org/10.1080/15257779508010694
Publikováno v:
Tetrahedron Letters. 35:8517-8520
A high yield process for the conversion of 2,2′-cyclouridine to 2′-azido-2′-deoxyuridine was developed. The procedure utilizes a lithium azide:TMEDA complex generated in situ from the reaction of lithium fluoride and azidotrimethylsilane in DMF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cebf999cd97a0c26ea3d72b592300c4f
https://doi.org/10.1016/s0040-4039(00)78425-5
https://doi.org/10.1016/s0040-4039(00)78425-5
Autor:
Chandra Vargeese, Yansheng Zhai, Alecia Settle, Gary P. Kirschenheuter, Colleen R. Siedem, Wolfgang Pieken, Danny P. C. McGee
Publikováno v:
ChemInform. 26
The synthesis of 2′-amino-2′-deoxypyrimidine 5′-triphosphates is described. The 2′-amino-2′-deoxyuridine 5′-triphosphate is obtained from uridine in four steps with 25% overall yield. The 2′-amino-2′-deoxycytidine 5′-triphosphate is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ca9d74ba162c561b56fde6a66716d9e
https://doi.org/10.1002/chin.199547275
https://doi.org/10.1002/chin.199547275
Autor:
Qi-Long Ying, Suzanne E. Mangold, Sherman E. Ross, Lyle W. Spruce, Sanford R. Simon, Raymond T. Cunningham, John C. Cheronis, Gary P. Kirschenheuter, Maciej Wieczorek
Publikováno v:
Bioorganic Chemistry. 20:345-355
The synthesis and evaluation of 4-(methylsulfinyl)phenyl 2-(1-methyl-2-pyrrolyl)butyrate (CE-0266) and the related sulfide and sulfone derivatives, CE-0265 and CE-0267, respectively, are described. The potency of the inhibitors toward human neutrophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f521790e5911eab642fbae00198ea40
https://doi.org/10.1016/0045-2068(92)90044-4
https://doi.org/10.1016/0045-2068(92)90044-4
Publikováno v:
Biochemistry. 36(10)
We incorporated a phosphonate irreversible inhibitor of neutrophil elastase into a randomized DNA library and, using the SELEX process, iteratively selected these assemblies for the most potent elastase inhibitors. The inhibitors were selected agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a013469e9f4455a10b570dcfb522b4af
https://pubmed.ncbi.nlm.nih.gov/9062133
https://pubmed.ncbi.nlm.nih.gov/9062133
Publikováno v:
Chemistrybiology. 2(11)
Introduction : We describe a new approach to drug discovery which joins the technologies of medicinal and combinatorial chemistry, allowing selection of the most active variant of a lead compound from a large (>10 12 ) pool. A small-molecule covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d24ba601608ab9acfa585ba93d48d96
https://pubmed.ncbi.nlm.nih.gov/9383481
https://pubmed.ncbi.nlm.nih.gov/9383481
Publikováno v:
ChemInform. 26
A high yield process for the conversion of 2,2′-cyclouridine to 2′-azido-2′-deoxyuridine was developed. The procedure utilizes a lithium azide:TMEDA complex generated in situ from the reaction of lithium fluoride and azidotrimethylsilane in DMF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79232a802c60294fd74f3e5a07c12915
https://doi.org/10.1002/chin.199516280
https://doi.org/10.1002/chin.199516280
Publikováno v:
Journal of Agricultural and Food Chemistry. 34:279-282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1fe630a98d763638919ebf9d7f9b3d0
https://doi.org/10.1021/jf00068a033
https://doi.org/10.1021/jf00068a033
Autor:
Caetan Vaz, Gary W. Griffin, Siegfried Christensen, Pesi Umrigar, David C. Lankin, Gary P. Kirschenheuter
Publikováno v:
Tetrahedron. 41:2069-2080
A series of Me substituted 1,2-diphenylcyclobutenes was subjected to dye-sensitized photooxidanon in the presence ofmethylene blue. In the case of the 3,3-dimcthyl-, 3,3,4-tnmethyl- and 3,3,4,4tetramcthyl, 2-diphcnylcyclobutencs, the sensitized oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0be16ea688f1660352bcbdcb40ce1c2
https://doi.org/10.1016/s0040-4020(01)96577-9
https://doi.org/10.1016/s0040-4020(01)96577-9
Publikováno v:
The Journal of Physical Chemistry. 92:1436-1440
In order to better understand why the formulation of sulfilimine intermediates facilitates the oxidation of some aminoazines, we have carried out a computational analysis of 2-aminopyrimidine (II) and S,S-dimethyl-N-2- (pyrimidinyl)sulfilimine (III).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::443253ea3f8ae64841d1f84f2edb94a8
https://doi.org/10.1021/j100317a015
https://doi.org/10.1021/j100317a015