Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Gary P, Brennan"'
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Autor:
Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels o
Externí odkaz:
https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/947f4670cbc44850b672a4bfb4a143e6
Autor:
Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel, David C. Henshall
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs during the development of epilepsy
Externí odkaz:
https://doaj.org/article/437cebdae0ed4f06ac210951c4c7a083
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2740 (2022)
Brain development occurs until adulthood, with time-sensitive processes happening during embryo development, childhood, and puberty. During early life and childhood, dynamic changes in the brain are critical for physiological brain maturation, and th
Externí odkaz:
https://doaj.org/article/b1913d86414e46739128624709263783
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
RNA modifications have emerged as an additional layer of regulatory complexity governing the function of almost all species of RNA. N6-methyladenosine (m6A), the addition of methyl groups to adenine residues, is the most abundant and well understood
Externí odkaz:
https://doaj.org/article/2c0ea216f3444ef39c07d55702d50734
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Background and Rationale: Bi-directional neuronal-glial communication is a critical mediator of normal brain function and is disrupted in the epileptic brain. The potential role of aberrant microglia and astrocyte function during epileptogenesis is i
Externí odkaz:
https://doaj.org/article/f4fa7057264b4718a44a40eeeb6815e5
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105179- (2021)
Epilepsy is a network disorder driven by fundamental changes in the function of the cells which compose these networks. Driving this aberrant cellular function are large scale changes in gene expression and gene expression regulation. Recent studies
Externí odkaz:
https://doaj.org/article/ed02a26beb67452b8271e1e373d985cd
Autor:
Gary P. Brennan, Sebastian Bauer, Tobias Engel, Eva M. Jimenez-Mateos, Federico Del Gallo, Thomas D.M. Hill, Niamh M.C. Connolly, Lara S. Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R. Reschke, Norman Delanty, Jochen H.M. Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C. Henshall
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105048- (2020)
Epilepsy diagnosis is complex, requires a team of specialists and relies on in-depth patient and family history, MRI-imaging and EEG monitoring. There is therefore an unmet clinical need for a non-invasive, molecular-based, biomarker to either predic
Externí odkaz:
https://doaj.org/article/072c418aab5a4a749a92db661a9cf3ff
Autor:
Aasia Batool, Thomas D. M. Hill, Ngoc T. Nguyen, Elena Langa, Mairéad Diviney, Catherine Mooney, Gary P. Brennan, Niamh M. C. Connolly, Amaya Sanz-Rodriguez, Brenton L. Cavanagh, David C. Henshall
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2020)
Repetitive or prolonged seizures (status epilepticus) can damage neurons within the hippocampus, trigger gliosis, and generate an enduring state of hyperexcitability. Recent studies have suggested that microvesicles including exosomes are released fr
Externí odkaz:
https://doaj.org/article/46abeaf665154000a4909c438eaf4e3c
Autor:
Rana Raoof, Sebastian Bauer, Hany El Naggar, Niamh M.C. Connolly, Gary P. Brennan, Elizabeth Brindley, Thomas Hill, Hazel McArdle, Elaine Spain, Robert J. Forster, Jochen H.M. Prehn, Hajo Hamer, Norman Delanty, Felix Rosenow, Catherine Mooney, David C. Henshall
Publikováno v:
EBioMedicine, Vol 38, Iss , Pp 127-141 (2018)
Background: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to br
Externí odkaz:
https://doaj.org/article/632bc337534f44689d22d27b78ebe8f0