Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Gary Ott"'
Publikováno v:
International Oil Spill Conference Proceedings. 2017:1-20
Today, 24/7 news and social media herald, “Another Disaster!” The gap widens between public expectations – what is wanted – and what government emergency responders can deliver. Further, public trust in government evaporates when individual s
Autor:
John D. Campbell, Holger Kanzler, Carlo Calacsan, Melissa A. Kachura, Bob Milley, Gary Ott, Robert L. Coffman, Radwan Kiwan
Publikováno v:
Bioconjugate Chemistry
We have synthesized and characterized a novel phosphorothioate CpG oligodeoxynucleotide (CpG ODN)-Ficoll conjugated nanoparticulate adjuvant, termed DV230-Ficoll. This adjuvant was constructed from an amine-functionalized-Ficoll, a heterobifunctional
Autor:
Holger Kanzler, John D. Campbell, Robert Milley, Atul Sathe, Melissa A. Kachura, Sariah A. Kell, Robert L. Coffman, Brian E. Hall, Carlo Calacsan, Gary Ott, Radwan Kiwan, Colin Hickle
Publikováno v:
The Journal of Immunology. 196:284-297
Nanoparticulate delivery systems for vaccine adjuvants, designed to enhance targeting of secondary lymphoid organs and activation of APCs, have shown substantial promise for enhanced immunopotentiation. We investigated the adjuvant activity of synthe
Publikováno v:
International Oil Spill Conference Proceedings. 2014:1172-1185
Effective response to oil spills can be challenging, especially when multiple levels of government are involved. When an oil spill threatens the coast, local officials and communities are concerned about response strategies and potential impacts, whi
Autor:
Matthew L. Wheeler, Baidong Hou, Martin F. Bachmann, Lili Kuzmich, Anthony L. DeFranco, Ming Ji, Linda M. Lee, Philippe Saudan, Robert L. Coffman, Gary Ott
Publikováno v:
Immunity. 34:375-384
Summary The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant fo
Autor:
Robert L. Coffman, Franck J. Barrat, Jean H. Chan, Carlo Calacsan, Emily Damon, Tracy Matray, Cristiana Guiducci, Gary Ott, Kyung Dall Lee
Publikováno v:
The Journal of Experimental Medicine
Human plasmacytoid dendritic cells (PDCs) can produce interferon (IFN)-alpha and/or mature and participate in the adaptive immune response. Three classes of CpG oligonucleotide ligands for Toll-like receptor (TLR)9 can be distinguished by different s
Autor:
Christi Abbate, Karen L. Fearon, Tracy dela Cruz, Debbie Higgins, Gary Van Nest, David Passmore, Jason Marshall, Stephen Tuck, Gary Ott, Priscilla Yee, Glen Teshima
Publikováno v:
Cellular Immunology. 229:93-105
The immunostimulatory effects of bacterial DNA on mammalian cells have been localized to unmethylated CpG motifs, and synthetic CpG-containing oligodeoxynucleotides that mimic these effects are known as immunostimulatory sequences (ISS). We have foun
Publikováno v:
Journal of Controlled Release. 85:263-270
Groups of 10 Balb/c mice were immunized intranasally (IN) with influenza haemagglutinin (HA), and a genetically detoxified mutant of heat-labile enterotoxin from Escherichia coli (LTK63) at several different doses. IN immunization at the optimal dose
Autor:
Wendy Peters, Gary Ott, Marc Dupuis, Israel F. Charo, Donald M. McDonald, Allyson LaBarbara, Kimberly Denis-Mize
Publikováno v:
European Journal of Immunology. 31:2910-2918
The mechanisms associated with the immunostimulatory activity of vaccine adjuvants are still poorly understood. We have undertaken a study to determine whether antigen-presenting cell trafficking is modified by administration of the submicron emulsio
Publikováno v:
Critical Care Medicine. 44:489-489