Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gary N.Y. Chan"'
Autor:
David B. Banks, Gary N.Y. Chan, David S. Miller, Emily V. Mesev, Ronald E. Cannon, Rebecca A Evans
Publikováno v:
Neuroscience Letters. 639:103-113
P-glycoprotein (P-gp), Breast cancer resistance protein (BCRP) and Multidrug resistance-associated protein 2 (MRP2) residing at the blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are major obstacles for drug delivery to the Centra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7fa4fc0f681fbdbbe0cfe0f45e5a27
https://doi.org/10.1016/j.neulet.2016.12.049
https://doi.org/10.1016/j.neulet.2016.12.049
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 38(5)
The blood–brain barrier is a microvascular network that (1) provides neuroprotection from metabolic and environmental toxins and (2) limits the delivery of therapeutics to the central nervous system (CNS). The ATP-binding cassette transporter P-gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ebb0456df5deb4d2fd138a02bdb8d03
https://pubmed.ncbi.nlm.nih.gov/28447863
https://pubmed.ncbi.nlm.nih.gov/28447863
Autor:
Gary N.Y. Chan, Ronald E. Cannon
Publikováno v:
Curr Protoc Pharmacol
Current Protocols in Pharmacology
Current Protocols in Pharmacology
The blood-brain barrier plays an important role in neuroprotection; however, it can be a major obstacle for drug delivery to the brain. This barrier primarily resides in the brain capillaries and functions as an interface between the brain and periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed09377f0e27ed96c4daf3793cd2bd8
https://pubmed.ncbi.nlm.nih.gov/28306152
https://pubmed.ncbi.nlm.nih.gov/28306152
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:4481-4488
The membrane-associated drug transporter P-glycoprotein (P-gp) plays an essential role in drug efflux from the brain. Induction of this protein at the blood-brain barrier (BBB) could further affect the ability of a drug to enter the brain. At present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c92b5e17fc42396a3698b677de72afe
https://doi.org/10.1128/aac.00486-13
https://doi.org/10.1128/aac.00486-13
Autor:
Vijay R. More, Keith D Oliver, David S. Miller, Gary N.Y. Chan, Christopher R. Campos, Ronald E. Cannon, Rebecca A Evans
Lipid sensor peroxisome proliferator-activated receptor alpha (PPAR- α) is the master regulator of lipid metabolism. Dietary release of endogenous free fatty acids, fibrates, and certain persistent environmental pollutants, e.g. perfluoroalkyl fire-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8032db70ad761a163ee5bd28e55f1257
https://europepmc.org/articles/PMC5453444/
https://europepmc.org/articles/PMC5453444/
Autor:
Edwin C. Y. Chow, K. Sandy Pang, Gary N.Y. Chan, Ronald E. Cannon, Eason Lee, David S. Miller, Christopher R. Campos, Reina Bendayan, Matthew R. Durk, John C. Peart
Publikováno v:
Journal of Neurochemistry. 123:944-953
Induction of the multidrug resistance protein 1 (MDR1)/P-glycoprotein (P-gp) by the vitamin D receptor (VDR) was investigated in isolated rat brain capillaries and rat (RBE4) and human (hCMEC/D3) brain microvessel endothelial cell lines. Incubation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4237d69d2b26eb2545869837668f5d9e
https://doi.org/10.1111/jnc.12041
https://doi.org/10.1111/jnc.12041
Publikováno v:
Trends in Pharmacological Sciences. 31:22-35
Treatment of human immunodeficiency virus (HIV) infection involves a combination of several antiviral agents belonging to different pharmacological classes. This combination is referred to as highly active antiretroviral therapy (HAART). This treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a8fecece28f442c5d4ea285454cd6d
https://doi.org/10.1016/j.tips.2009.10.001
https://doi.org/10.1016/j.tips.2009.10.001
Autor:
Gary N.Y. Chan, Kevin R. Robillard, Reina Bendayan, William Cameron, Guijin Zhang, Charles la Porte
Publikováno v:
Antimicrobial agents and chemotherapy. 58(3)
The blood-testis barrier and blood-brain barrier are responsible for protecting the male genital tract and central nervous system from xenobiotic exposure. In HIV-infected patients, low concentrations of antiretroviral drugs in cerebrospinal fluid an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ae2646d0f776ecdcc9a9fa9837b8f1
https://pubmed.ncbi.nlm.nih.gov/24379203
https://pubmed.ncbi.nlm.nih.gov/24379203
Publikováno v:
Journal of neurochemistry. 127(3)
Intracerebral microdialysis was utilized to investigate the effect of P-glycoprotein (a drug efflux transporter) induction at the mouse blood–brain barrier (BBB) on brain extracellular fluid concentrations of quinidine, an established substrate of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d216f9f7f7369f0770813bc9ed7969
https://pubmed.ncbi.nlm.nih.gov/23777437
https://pubmed.ncbi.nlm.nih.gov/23777437
Publikováno v:
Current pharmaceutical design. 20(10)
Membrane-associated drug transporters are important determinants of antiretroviral drug disposition in the central nervous system during HIV-1 infection. A number of influx and efflux transport proteins expressed at the blood-brain barrier, blood-cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3de851916bb003a0eaacba4d1b46d7d
https://pubmed.ncbi.nlm.nih.gov/23789949
https://pubmed.ncbi.nlm.nih.gov/23789949