Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Gary Mather"'
1
Phase I Clinical Trial of MPC-6827 (Azixa), a Microtubule Destabilizing Agent, in Patients with Advanced Cancer
Autor: Apostolia Maria Tsimberidou, Matthias C. Schabel, Terri Warren, David S. Hong, Razelle Kurzrock, Anil Chhabra, Gary Mather, Cynthia Uehara, Brent A. Evans, Edward Swabb, Deane Woodland, Wallace Akerley
Publikováno v: Molecular Cancer Therapeutics. 9:3410-3419
MPC-6827 (Azixa) is a small-molecule microtubule-destabilizing agent that binds to the same (or nearby) sites on β-tubulin as colchicine. This phase I study was designed to determine the dose-limiting toxicities (DLT), maximum tolerated dose (MTD),
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64cdff34de10ebe32807c1ec60619b0
https://doi.org/10.1158/1535-7163.mct-10-0516
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2
Discovery of 2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a Potent Inducer of Apoptosis with High In Vivo Activity
Autor: John Drewe, Kevin Jessing, Raouf A. Hussain, Christopher M. Pleiman, Khanh C. Hoang, Nilantha Sudath Sirisoma, Songchun Jiang, Gary Mather, Hong Zhang, Azra Pervin, Ben Tseng, Vijay Baichwal, Shailaja Kasibhatla, J. Adam Willardsen, Sui Xiong Cai, Mark B. Anderson
Publikováno v: Journal of Medicinal Chemistry. 51:4771-4779
Using a live cell, high-throughput caspase-3 activator assay, we have identified a novel series of 4-anilinoquinazolines as inducers of apoptosis. In this report, we discuss the discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine, co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d961ca79c09484fddbd547986ecdef31
https://doi.org/10.1021/jm8003653
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3
Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring
Autor: John Drewe, Gary Mather, Hong Zhang, Christopher M. Pleiman, Songchun Jiang, Azra Pervin, Ben Tseng, Sui Xiong Cai, Mark B. Anderson, Shailaja Kasibhatla, J. Adam Willardsen, Nilantha Sudath Sirisoma
Publikováno v: Bioorganicmedicinal chemistry letters. 20(7)
As a continuation of our efforts to discover and develop apoptosis inducing N-methyl-4-(4-methoxyanilino)quinazolines as novel anticancer agents, we explored substitution at the 5-, 6-, 7-positions of the quinazoline and replacement of the quinazolin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96cb7cf578fe3e5e7d7d2cff47de72f
https://pubmed.ncbi.nlm.nih.gov/20188546
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4
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration
Autor: Mark B. Anderson, Azra Pervin, Nilantha Sudath Sirisoma, Sui Xiong Cai, Ben Tseng, Hong Zhang, Gary Mather, Songchun Jiang, John Drewe, J. Adam Willardsen, Shailaja Kasibhatla, Christopher M. Pleiman
Publikováno v: Journal of medicinal chemistry. 52(8)
As a continuation of our structure-activity relationship (SAR) studies on 4-anilinoquinazolines as potent apoptosis inducers and to identify anticancer development candidates, we explored the replacement of the 2-Cl group in our lead compound 2-chlor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4064c1c0b61b9a76bb2c0a8ed1fcc67
https://pubmed.ncbi.nlm.nih.gov/19296653
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