Výsledky vyhledávání - "Gary M. Noonan"

Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction

Autor: Zhang Enxuan, Chris D. Parsons, David C. McKinney, Kevin William Leslie, Zhi-qing Liu, Miguel Gonzalez, Mark A. Graham, Jackson Lucinda Victoria, Rachel H. Munday, Jun-wang Zhang, Janette H. Cherryman, James Douglas, David Whittaker, Gary M. Noonan

Publikováno v: Organic Process Research & Development. 25:57-67

New route development activities toward ceralasertib (AZD6738) have resulted in the discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic understanding resulting f...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08740d393a7148e1911afcefc4eab4f1
https://doi.org/10.1021/acs.oprd.0c00483

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Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis

Autor: Na Jin, Andrew G. Leach, Simone Tomasi, Guy C. Lloyd-Jones, Gary M. Noonan, Katherine J. Geogheghan, Hannah L. D. Hayes, Ran Wei, Michele Assante

Publikováno v: Hayes, H L D, Wei, R, Assante, M, Geogheghan, K J, Jin, N, Tomasi, S, Noonan, G, Leach, A G & Lloyd-jones, G C 2021, ' Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis ', Journal of the American Chemical Society . https://doi.org/10.1021/jacs.1c06863
Hayes, H L D, Wei, R, Assante, M, Geogheghan, K J, Jin, N, Tomasi, S, Noonan, G, Leach, A G & Lloyd-Jones, G C 2021, ' Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis ', Journal of the American Chemical Society, vol. 143, no. 36, pp. 14814–14826 . https://doi.org/10.1021/jacs.1c06863

The kinetics and mechanism of the base-catalyzed hydrolysis (ArB(OR)2 → ArB(OH)2) and protodeboronation (ArB(OR)2 → ArH) of a series of boronic esters, encompassing eight different polyols and 10 polyfluoroaryl and heteroaryl moieties, have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4228a076aefa4b44b13f2fb24b9c014b
https://pubmed.ncbi.nlm.nih.gov/34460235

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A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state

Autor: Gary M. Noonan, Andrew G. Leach

Publikováno v: Organic & Biomolecular Chemistry. 13:2555-2560

A combined experimental and computational study suggests that a reduction in the entropy of activation in the solid state can lead to the protodeboronation of boronic acids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227feaf3fc05a93414fe21c04ff62f54
https://doi.org/10.1039/c4ob02543a

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Expanding the scope of silane-mediated hydrodehalogenation reactions

Autor: Gary M. Noonan, Timothy W. Gorman, Barry R. Hayter, Andrew D. Campbell, Benjamin E. Partridge, Gill M. Lamont

Publikováno v: Tetrahedron Letters. 54:4518-4521

A palladium-catalysed, silane-mediated hydrodehalogenation (HDH) reaction with increased substrate scope has been developed. Whereas previous attempts to reduce carboxylic acid or phenol-containing aryl halides using silane-based HDH conditions faile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9d2cb16114f14063c582002722e77b0
https://doi.org/10.1016/j.tetlet.2013.06.063

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Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection

Autor: Andrew J. Ratcliffe, Mark Craighead, Neil R. Stokes, Nathan Chaffer-Malam, Cedric Charrier, Gary M. Noonan, Sarfraz Mohmed, Victoria J. Savage, Stuart A. Best, Anthony Huxley, Ralph Kirk, Helen Box, Anne-Marie Salisbury

Publikováno v: Antimicrobial agents and chemotherapy. 60(9)

There is an urgent need for new antibiotics to treat multidrug-resistant Neisseria gonorrhoeae . In this report, the microbiology, in vivo pharmacokinetics, and efficacy of REDX05931, a representative novel tricyclic topoisomerase inhibitor, were eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95143d8d2a655c3dcce17fd32e001199
https://pubmed.ncbi.nlm.nih.gov/27324777

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Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV

Autor: Nathan Chaffer-Malam, Mario Uosis-Martin, Henry Forward, Stuart A. Best, Ralph Kirk, Andrew J. Ratcliffe, Richard Metzger, Neil R. Stokes, Gary M. Noonan, Victoria J. Savage, Anne-Marie Salisbury, Cedric Charrier, Sarfraz Mohmed, Anthony Huxley, Emmanuel Moyo

Publikováno v: The Journal of antimicrobial chemotherapy. 71(7)

Objectives The objective of this study was to characterize the in vitro and in vivo biological properties of a novel series of small-molecule bacterial type IIA topoisomerase inhibitors. Methods Bacterial susceptibility testing was performed by broth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770f84ca9630ffd1ec1cb7b32f6ceff5
https://pubmed.ncbi.nlm.nih.gov/27032669

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Deuterodehalogenation—a mild method for synthesising deuterated heterocycles

Autor: Gary M. Noonan, Thomas A. Moss, Emma C. Durham, Bryan Roberts, Craig S. Donald

Publikováno v: Tetrahedron Letters. 55:3305-3307

We report a mild and efficient method for introducing deuterium into a range of heterocycles by reacting readily available halide analogues in a deuterodehalogenation reaction using D8-IPA or Et3SiD under palladium-catalysed conditions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f0b73e2d4535ee7479ed4aaf881431d
https://doi.org/10.1016/j.tetlet.2014.04.025

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ChemInform Abstract: Deuterodehalogenation - A Mild Method for Synthesising Deuterated Heterocycles

Autor: Craig S. Donald, Bryan Roberts, Emma C. Durham, Gary M. Noonan, Thomas A. Moss

Publikováno v: ChemInform. 45

Optimized reaction conditions including 2-propanol-d8 as the deuterium source are developed for the deuterodehalogenation of various bromo- and chloro-substituted heterocycles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6334eb29a56f08478f8a5b96eab99446
https://doi.org/10.1002/chin.201445063

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ChemInform Abstract: Rhodium/Phospholane-Phosphite Catalysts Give Unusually High Regioselectivity in the Enantioselective Hydroformylation of Vinyl Arenes

Autor: Thomas Mahoney, Gary M. Noonan, Christopher J. Cobley, Matthew L. Clarke

Publikováno v: ChemInform. 45

Using the phospholane–phosphite ligand, BOBPHOS, almost perfect regioselectivities and high enantioselectivities (up to 92% ee) are observed in Rh catalysed enantioselective hydroformylation of vinyl arenes. This can be achieved under solvent-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b79ed957f0cd93c4d3df9d521d07efdf
https://doi.org/10.1002/chin.201421079

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