Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Gary M. Bokoch"'
Autor:
Michael A. White, Ritu Pathak, Michael Howell, Céline DerMardirossian, Violaine D. Delorme-Walker, Gary M. Bokoch, Anthony Anselmo
Publikováno v:
Developmental Cell. 23:397-411
SummaryThe exocyst complex plays a critical role in targeting and tethering vesicles to specific sites of the plasma membrane. These events are crucial for polarized delivery of membrane components to the cell surface, which is critical for cell moti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9669c84ecc708ed119bbb5b8d228666b
https://doi.org/10.1016/j.devcel.2012.06.014
https://doi.org/10.1016/j.devcel.2012.06.014
Autor:
Jeffrey R. Peterson, Violaine D. Delorme-Walker, Céline DerMardirossian, Gaudenz Danuser, Clare M. Waterman, Jonathan Chernoff, Gary M. Bokoch
Publikováno v:
The Journal of Cell Biology
p21-activated kinases are essential for spatial and temporal coordination of cytoskeletal dynamics with cellular adhesion during cell migration.
Cell motility requires the spatial and temporal coordination of forces in the actomyosin cytoskeleto
Cell motility requires the spatial and temporal coordination of forces in the actomyosin cytoskeleto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c6e03869ae3b78cd5fe028f974b25b
http://europepmc.org/articles/PMC3216326
http://europepmc.org/articles/PMC3216326
Autor:
Judith A. Boyle, Laurie S. Minamide, Richard C. Davis, James R. Bamburg, Judith A. Coppinger, Yunhe Bao, Timothy Y. Huang, Gary M. Bokoch, John R. Yates, Sankar Maiti
Publikováno v:
Journal of Biological Chemistry. 285:5450-5460
Cofilin-actin bundles (rods), which form in axons and dendrites of stressed neurons, lead to synaptic dysfunction and may mediate cognitive deficits in dementias. Rods form abundantly in the cytoplasm of non-neuronal cells in response to many treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b2ef6aa08425a1f1aea7dc82f1258b
https://doi.org/10.1074/jbc.m109.063768
https://doi.org/10.1074/jbc.m109.063768
Publikováno v:
Molecular Biology of the Cell
Reactive oxygen species (ROS) generated by the NADPH oxidase system have been shown to be necessary for the invadopodia formation and function. We show here that the abolishment of Src-mediated phosphorylation of NoxA1 and Tks4 blocks their binding,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52e72baf7e74fdd101130d23a8a461a
http://europepmc.org/articles/PMC2993755
http://europepmc.org/articles/PMC2993755
Publikováno v:
The Journal of Immunology. 183:2718-2728
Rac1 and Rac2, members of the small Rho GTPase family, play essential roles in coordinating directional migration and superoxide production during neutrophil responses to chemoattractants. Although earlier studies in Rac1 and Rac2 knockout mice have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71d5715fbc76bda631dc301e32d3bfb
https://doi.org/10.4049/jimmunol.0900849
https://doi.org/10.4049/jimmunol.0900849
Autor:
Gary M. Bokoch
Publikováno v:
European Journal of Haematology. 51:313-317
The mechanisms used by phagocytic leukocytes in the process of bacterial killing are regulated by GTP-binding proteins of the Ras superfamily. In particular, the formation of toxic oxygen metabolites via the NADPH oxidase requires the action of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68d6408f09b961568fafb7f39ca2392
https://doi.org/10.1111/j.1600-0609.1993.tb01614.x
https://doi.org/10.1111/j.1600-0609.1993.tb01614.x
Publikováno v:
Developmental Cell. 15(5):691-703
SummaryActin and its key regulatory component, cofilin, are found together in large rod-shaped assemblies in neurons subjected to energy stress. Such inclusions are also enriched in Alzheimer's disease brain, and appear in transgenic models of neurod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9526c4baf310954d9ebe6160d698de77
Publikováno v:
Molecular Biology of the Cell. 19:2984-2994
NADPH oxidase (Nox) family enzymes are one of the main sources of cellular reactive oxygen species (ROS), which have been shown to function as second messenger molecules. To date, seven members of this family have been reported, including Nox1-5 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377b3c1294acb0d5d4a74546834b4737
https://doi.org/10.1091/mbc.e08-02-0138
https://doi.org/10.1091/mbc.e08-02-0138
Autor:
Gary M. Bokoch, Bo van Deurs, Patrick Salmon, Makoto Sawada, Kirstine Roepstorff, Cristophe Cudre-Maroux, Izabela Rasmussen, Frederik Vilhardt
Publikováno v:
Journal of Biological Chemistry. 283:7983-7993
The p21-activated kinase-1 (PAK1) is best known for its role in the regulation of cytoskeletal and transcriptional signaling pathways. We show here in the microglia cell line Ra2 that PAK1 regulates NADPH oxidase (NOX-2) activity in a stimulus-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e9df4e31409fdb8834d1537e67f276
https://doi.org/10.1074/jbc.m708281200
https://doi.org/10.1074/jbc.m708281200
Autor:
Gary M. Bokoch, Céline DerMardirossian, Kunlin Jin, David A. Greenberg, Adil A. Khan, Surita Banwait, Xiao Ou Mao
Publikováno v:
The FASEB Journal. 22:1737-1747
The signal transduction pathways involved in neuronal death are not well understood. Neuroglobin (Ngb), a recently discovered vertebrate globin expressed predominantly in the brain, shows increased expression in neurons in response to oxygen deprivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620188a6c7d4e9cd0ee328067278194f
https://doi.org/10.1096/fj.07-100784
https://doi.org/10.1096/fj.07-100784