Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Gary M Diffee"'
Autor:
Priya Balasubramanian, Anne E Schaar, Grace E Gustafson, Alex B Smith, Porsha R Howell, Angela Greenman, Scott Baum, Ricki J Colman, Dudley W Lamming, Gary M Diffee, Rozalyn M Anderson
Publikováno v:
eLife, Vol 11 (2022)
The loss of skeletal muscle function with age, known as sarcopenia, significantly reduces independence and quality of life and can have significant metabolic consequences. Although exercise is effective in treating sarcopenia it is not always a viabl
Externí odkaz:
https://doaj.org/article/70070234940c48fc8d99e9a3f893e406
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Aging is associated with a decline in cardiac function. Exercise intervention has been suggested as a way to improve this decrement. Age-related decline in cardiac function is associated with decreases in fatty acid oxidation, mitochondrial function
Externí odkaz:
https://doaj.org/article/32ba1792ee7242a9b85c823d722f3e24
Autor:
Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger, Adam R. Konopka
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could ext
Externí odkaz:
https://doaj.org/article/ce8d8741c2d444e894d37204ef2479d7
Autor:
Fergus M. Payne, Samantha Nie, Gary M. Diffee, Gerard T. Wilkins, David S. Larsen, Joanne C. Harrison, James C. Baldi, Ivan A. Sammut
Publikováno v:
Physiological Reports, Vol 12, Iss 6, Pp n/a-n/a (2024)
Abstract Patients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with
Externí odkaz:
https://doaj.org/article/e44a89140be34264b3c3104a075603b8
Autor:
Yann Huey Ng, Regis R. Lamberts, Peter P. Jones, Ivan A. Sammut, Gary M. Diffee, Gerard T. Wilkins, James C. Baldi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Systolic and diastolic dysfunction in diabetes have frequently been associated with abnormal calcium (Ca2+) regulation. However, there is emerging evidence that Ca2+ mishandling alone is insufficient to fully explain diabetic heart dysfuncti
Externí odkaz:
https://doaj.org/article/969dcf6297a245a9aea8aa4be6b03104
Publikováno v:
Physiological Reports, Vol 8, Iss 5, Pp n/a-n/a (2020)
Abstract Cancer cachexia is the loss of lean muscle mass with or without loss of fat mass that is often highlighted by a progressive loss of skeletal muscle mass and function. The mechanisms behind the cachexia‐related loss of skeletal muscle are p
Externí odkaz:
https://doaj.org/article/aa873f23b41a4906b871cd09e2017673
Autor:
Jake A. Melby, Kyle A. Brown, Zachery R. Gregorich, David S. Roberts, Emily A. Chapman, Lauren E. Ehlers, Zhan Gao, Eli J. Larson, Yutong Jin, Justin R. Lopez, Jared Hartung, Yanlong Zhu, Sean J. McIlwain, Daojing Wang, Wei Guo, Gary M. Diffee, Ying Ge
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Single-cell proteomics has emerged as a powerful method to characterize cellular phenotypic heterogeneity and the cell-specific functional networks underlying biological processes. However, significant challenges remain in single-cell proteomics for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8932f3b247e9f0f6c21dfb64da03824
https://doi.org/10.1073/pnas.2222081120
https://doi.org/10.1073/pnas.2222081120
Autor:
Jake A. Melby, Kyle A. Brown, Zachery R. Gregorich, David S. Roberts, Emily A. Chapman, Lauren E. Ehlers, Zhan Gao, Eli J. Larson, Yutong Jin, Justin Lopez, Jared Hartung, Yanlong Zhu, Daojing Wang, Wei Guo, Gary M. Diffee, Ying Ge
Single-cell proteomics has emerged as a powerful method to characterize cellular phenotypic heterogeneity and the cell-specific functional networks underlying biological processes. However, significant challenges remain in single-cell proteomics for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5200774f0796c647acd996ed9c6d17
https://doi.org/10.1101/2022.12.29.521273
https://doi.org/10.1101/2022.12.29.521273
Autor:
Angela C. Greenman, Gary M. Diffee, Amelia S. Power, Gerard T. Wilkins, Olivia M. S. Gold, Jeffrey R. Erickson, James C. Baldi
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 132(6)
The cardiovascular benefits of regular exercise are unequivocal, yet patients with type 2 diabetes respond poorly to exercise due to a reduced cardiac reserve. The contractile response of diabetic cardiomyocytes to β-adrenergic stimulation is attenu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5acabcef55765dd4817660c784bb12
https://pubmed.ncbi.nlm.nih.gov/35482324
https://pubmed.ncbi.nlm.nih.gov/35482324
Autor:
Anne E Schaar, Priya Balasubramanian, Grace E Gustafson, Alex B Smith, Porsha R Howell, Angela Greenman, Scott Baum, Ricki J Colman, Dudley W Lamming, Gary M Diffee, Rozalyn M Anderson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fbeeecbde4d225780a916ad5b7254db
https://doi.org/10.7554/elife.71282.sa2
https://doi.org/10.7554/elife.71282.sa2