Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Gary M, Pollack"'
Autor:
Matthew E. Layton, Gary M. Pollack, John R. White, Brandon T. Gufford, Mary F. Paine, Garrett R. Ainslie, Jeannie M. Padowski
Publikováno v:
Clinical and Translational Science. 10:380-386
Easy-to-use naloxone formulations are needed to help address the opioid overdose epidemic. The pharmacokinetics of i.v., i.m., and a new i.n. naloxone formulation (2 mg) were compared in six healthy volunteers. Relative to i.m. naloxone, geometric me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26a5db1d464f6886e7aa712b442bf81b
https://doi.org/10.1111/cts.12473
https://doi.org/10.1111/cts.12473
Autor:
Jeannie M. Padowski, Gary M. Pollack
Publikováno v:
Brain Research. 1426:1-17
Active efflux transport processes at the blood-brain barrier (BBB), such as P-glycoprotein (P-gp)-mediated efflux, can limit brain uptake of therapeutics. Accurate determination of the consequent impact on brain uptake is assumed to require sampling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca236e38382a629acd9594df1fd504c
https://doi.org/10.1016/j.brainres.2011.10.009
https://doi.org/10.1016/j.brainres.2011.10.009
Autor:
Jeannie M. Padowski, Gary M. Pollack
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 38:743-767
Development of CNS-targeted agents often focuses on identifying compounds with "good" CNS exposure (brain-to-blood partitioning1). Some compounds undergoing enterohepatic recycling (ER) evidence a partition coefficient, K (p,brain) (expressed as C (b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0087c445697602db0426693685b1e383
https://doi.org/10.1007/s10928-011-9218-0
https://doi.org/10.1007/s10928-011-9218-0
Autor:
Jeannie M. Padowski, Gary M. Pollack
Publikováno v:
Journal of Pharmaceutical Sciences. 99:3226-3233
The central nervous system (CNS), efficiently isolated from the systemic circulation by the blood-brain barrier (BBB), represents a challenging therapeutic target. For CNS-targeted agents, augmenting brain exposure by increasing blood drug concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407240e5108abb9128b901bfe27e069c
https://doi.org/10.1002/jps.22070
https://doi.org/10.1002/jps.22070
Autor:
Rong Zhao, Gary M. Pollack
Publikováno v:
Biochemical Pharmacology. 78:1052-1059
The in situ brain perfusion technique was used to assess the impact of local capillary density, blood flow rate and P-gp-mediated efflux activity on regional drug exposure for the P-gp substrates colchicine, quinidine, verapamil, and loperamide, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a4d13cd2f6ac31171aba81116e49c
https://doi.org/10.1016/j.bcp.2009.06.001
https://doi.org/10.1016/j.bcp.2009.06.001
Publikováno v:
Toxicology and Applied Pharmacology. 238:90-99
Trichloroethylene (TCE) is a well-known carcinogen in rodents and concerns exist regarding its potential carcinogenicity in humans. Oxidative metabolites of TCE, such as dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are thought to be hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e878c68e19691a1690c2fcc717d016
https://doi.org/10.1016/j.taap.2009.04.019
https://doi.org/10.1016/j.taap.2009.04.019
Autor:
Gary M. Pollack, Thomas J. Raub, Jin Kyung Lee, Arlene S. Bridges, Kim L. R. Brouwer, Nita J. Patel, Koji Abe
Publikováno v:
Drug Metabolism and Disposition. 37:1916-1921
Breast cancer resistance protein (BCRP, ABCG2) is expressed in the hepatic canalicular membrane and mediates biliary excretion of xenobiotics including sulfate and glucuronide metabolites of some compounds. Hepatic Bcrp expression is sex-dependent, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19d84b649af6491225f5f741abe37dc
https://doi.org/10.1124/dmd.109.026815
https://doi.org/10.1124/dmd.109.026815
Publikováno v:
Pharmaceutical Research. 26:1657-1664
To assess the blood-brain barrier (BBB) permeability of 12 clinically-used drugs in mdr1a(+/+) and mdr1a(-/-) mice, and investigate the influence of lipophilicity, nonspecific brain tissue binding, and P-gp-mediated efflux on the rate of brain uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49640d5326dfd8b401a5f73728035f85
https://doi.org/10.1007/s11095-009-9876-4
https://doi.org/10.1007/s11095-009-9876-4
Autor:
Thomas J. Raub, Rong Zhao, Steven C. Kasper, Gary M. Pollack, Arlene S. Bridges, James A. Bacon, Geri A. Sawada
Publikováno v:
Drug Metabolism and Disposition. 37:1251-1258
Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been revealed recently. To investigate comprehensively the potential role of Bcrp at the murine BBB, a chemically diverse set of model compounds (cimetidine, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4b8e8e4c3643f515b9126a9bf5f9aa
https://doi.org/10.1124/dmd.108.025064
https://doi.org/10.1124/dmd.108.025064
Autor:
Robert A. Blouin, Gary M. Pollack
Publikováno v:
Pharmacotherapy. 29:134-137
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c5a9c1fa38d03c8576795a0749f943
https://doi.org/10.1592/phco.29.2.134
https://doi.org/10.1592/phco.29.2.134