Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Gary Loughran"'
Autor:
Simon A. Fromm, Kate M. O’Connor, Michael Purdy, Pramod R. Bhatt, Gary Loughran, John F. Atkins, Ahmad Jomaa, Simone Mattei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Developments in cryo-EM sample preparation and data collection are pivotal for structure determination. Fromm et al. present a 1.55 Å structure of the translating bacterial ribosome that provides new insights on its function and may allow for more p
Externí odkaz:
https://doaj.org/article/8b19dbac922a48bb8c1937b73fc110d6
Autor:
Christophe Penno, Mary O’Connell Motherway, Yuan Fu, Virag Sharma, Fiona Crispie, Paul D. Cotter, Benoit Houeix, Lokesh Joshi, Francesca Bottacini, Aoife O’Dwyer, Gary Loughran, John F. Atkins, Douwe van Sinderen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The human gut microbiome, of which the genus Bifidobacterium is a prevalent and abundant member, is thought to sustain and enhance human health. Several surface-exposed structures, including so-called sortase-dependent pili, represent import
Externí odkaz:
https://doaj.org/article/bc3969c2a76447c09958da50179cacdf
Autor:
Dmitry E. Andreev, Gary Loughran, Alla D. Fedorova, Maria S. Mikhaylova, Ivan N. Shatsky, Pavel V. Baranov
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Recent proteogenomic studies revealed extensive translation outside of annotated protein coding regions, such as non-coding RNAs and untranslated regions of mRNAs. This non-canonical translation is largely due to start codon plurality within
Externí odkaz:
https://doaj.org/article/29b0c5b7edd04b93a58129c5788f35cd
Autor:
Konstantinos Sofiadis, Natasa Josipovic, Milos Nikolic, Yulia Kargapolova, Nadine Übelmesser, Vassiliki Varamogianni‐Mamatsi, Anne Zirkel, Ioanna Papadionysiou, Gary Loughran, James Keane, Audrey Michel, Eduardo G Gusmao, Christian Becker, Janine Altmüller, Theodore Georgomanolis, Athanasia Mizi, Argyris Papantonis
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 6, Pp 1-17 (2021)
Abstract Spatial organization and gene expression of mammalian chromosomes are maintained and regulated in conjunction with cell cycle progression. This is perturbed once cells enter senescence and the highly abundant HMGB1 protein is depleted from n
Externí odkaz:
https://doaj.org/article/1c45f529d5074d11a54d216e9bc18458
Publikováno v:
Wellcome Open Research, Vol 5 (2022)
Abstract Background: Previously we reported the discovery of stop codon readthrough in AMD1 mRNA followed by ribosome stalling at the end of a conserved Open Reading Frame (ORF) that we termed AMD1. To explain the severe suppression of reporters fuse
Externí odkaz:
https://doaj.org/article/26be2f3e6da746988e14f013438efe8c
Publikováno v:
Viruses, Vol 13, Iss 7, p 1251 (2021)
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine. This recoding can effectively i
Externí odkaz:
https://doaj.org/article/b2b4e0e5c92c4c7dbc75d8752c6fbc4a
Autor:
Dmitry E Andreev, Maxim Arnold, Stephen J Kiniry, Gary Loughran, Audrey M Michel, Dmitrii Rachinskii, Pavel V Baranov
Publikováno v:
eLife, Vol 7 (2018)
Translation initiation is the rate-limiting step of protein synthesis that is downregulated during the Integrated Stress Response (ISR). Previously, we demonstrated that most human mRNAs that are resistant to this inhibition possess translated upstre
Externí odkaz:
https://doaj.org/article/37d6e8bce4cc4482ab33c3de14246b98
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192648 (2018)
The efficiency of start codon selection during ribosomal scanning in eukaryotic translation initiation is influenced by the context or flanking nucleotides surrounding the AUG codon. The levels of eukaryotic translation initiation factors 1 (eIF1) an
Externí odkaz:
https://doaj.org/article/ec785573cb3b4b33b8aea214646794ba
Autor:
Ioanna Tzani, Ivaylo P. Ivanov, Dmitri E. Andreev, Ruslan I. Dmitriev, Kellie A. Dean, Pavel V. Baranov, John F. Atkins, Gary Loughran
Publikováno v:
Open Biology, Vol 6, Iss 5 (2016)
Abundant evidence for translation within the 5′ leaders of many human genes is rapidly emerging, especially, because of the advent of ribosome profiling. In most cases, it is believed that the act of translation rather than the encoded peptide is i
Externí odkaz:
https://doaj.org/article/58d9126fd6844c1f89ec6871da0ac1cb
Publikováno v:
Nucleic Acids Research. 51:304-314
A stop codon entering the ribosome A-site is normally decoded by release factors that induce release of the polypeptide. Certain factors influence the efficiency of the termination which is in competition with elongation in either the same (readthrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e38c109a836d75764ec69a9b1adc6e
https://doi.org/10.1093/nar/gkac1180
https://doi.org/10.1093/nar/gkac1180