Výsledky vyhledávání - "Gary L. Thompson"

Akademický článek

Histone deacetylase 4 and 5 translocation elicited by microsecond pulsed electric field exposure is mediated by kinase activity

Autor: Zahra Safaei, Gary L. Thompson

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Electroporation-based technologies using microsecond pulsed electric field (µsPEF) exposures are established as laboratory and clinical tools that permeabilize cell membranes. We demonstrate a µsPEF bioeffect on nucleocytoplasmic import and export

Externí odkaz: https://doaj.org/article/e55c8c653a294dc8b9f36165f577d646

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Electrophoretic Transport Through Fibrocartilage Driven by Square and Sawtooth Pulses With Decreased Joule Heating

Autor: Prince M. Atsu, Zachary Nicolella, Maya Webb, Nicholas Brady, Eunice Nepomuceno, Connor Mowen, Gary L. Thompson

Publikováno v: IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. :1-6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78b1e4f56b79a7a5002807b91127f8dd
https://doi.org/10.1109/jerm.2023.3264116

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Akademický článek

nsPEF-induced PIP2 depletion, PLC activity and actin cytoskeletal cortex remodeling are responsible for post-exposure cellular swelling and blebbing

Autor: Gleb P. Tolstykh, Gary L. Thompson, Hope T. Beier, Zachary A. Steelman, Bennett L. Ibey

Publikováno v: Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 36-41 (2017)

Cell swelling and blebbing has been commonly observed following nanosecond pulsed electric field (nsPEF) exposure. The hypothesized origin of these effects is nanoporation of the plasma membrane (PM) followed by transmembrane diffusion of extracellul

Externí odkaz: https://doaj.org/article/b91cb4fcfc434f56b831c1c2c88e1787

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Electrical impedance decreases in annulus fibrosus cartilage exposed to microsecond pulsed electric fields ex vivo

Autor: Prince Mensah Atsu, Gary L Thompson

Publikováno v: Biomedical Physics & Engineering Express.

Electropermeabilization of biomembranes often is measured by microscopic imaging of a membrane-impermeable fluorophore that penetrates the cells following pulsed electric field (PEF) exposure. PEF exposure subsequently changes physiological propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6949c13d975ce6b1a1f6dca48434a638
https://doi.org/10.1088/2057-1976/acbd54

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Abstract 3314: Glioblastoma treatment using epigenetic modification induced by microsecond pulsed electric field (µsPEF) exposure

Autor: Zahra Safaei, Gary L Thompson

Publikováno v: Cancer Research. 82:3314-3314

Epigenetic modifications derived from changes in sub-cellular localization and activity of the post-translational histone modifying enzymes, histone deacetylases (HDACs) are one of the strategies to treat various types of cancer. Aberrant HDAC activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d43da33fd37308cc9f84c43bc10ef726
https://doi.org/10.1158/1538-7445.am2022-3314

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Akademický článek

Tracking Lysosome Migration within Chinese Hamster Ovary (CHO) Cells Following Exposure to Nanosecond Pulsed Electric Fields

Autor: Gary L. Thompson, Hope T. Beier, Bennett L. Ibey

Publikováno v: Bioengineering, Vol 5, Iss 4, p 103 (2018)

Above a threshold electric field strength, 600 ns-duration pulsed electric field (nsPEF) exposure substantially porates and permeabilizes cellular plasma membranes in aqueous solution to many small ions. Repetitive exposures increase permeabilization

Externí odkaz: https://doaj.org/article/de05e3c3a3ec450a81e6f5088955836d

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Cell encapsulation in gelatin bioink impairs 3D bioprinting resolution

Autor: Gary L. Thompson, Matthew Malpica, Amir K. Miri, Rachel Schwartz

Publikováno v: Journal of the mechanical behavior of biomedical materials. 103

Recent advances in three-dimensional (3D) bioprinting technologies have enabled precise patterning of cellular components along with biomimetic constructs for tissue engineering and regenerative medicine. The viscoelasticity of bioinks regulate print

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc5ce53c9ff4c8287447d590f2fd72b
https://pubmed.ncbi.nlm.nih.gov/31785543

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Tracking Lysosome Migration within Chinese Hamster Ovary (CHO) Cells Following Exposure to Nanosecond Pulsed Electric Fields

Autor: Hope T. Beier, Gary L. Thompson, Bennett L. Ibey

Publikováno v: Bioengineering
Volume 5
Issue 4
Bioengineering, Vol 5, Iss 4, p 103 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a79924a0600235c5a37bd6cd51c4a2

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Predicting Nonthermal Electroporation of Intervertebral Disc Tissue

Autor: Gary L. Thompson, Steven Schwartz

Publikováno v: 2018 IEEE International Microwave Biomedical Conference (IMBioC).

This paper investigates thresholds for nonthermal electroporation of cells within an intervertebral disc (IVD) using an in silico model. Simulations run in Comsol Multiphysics 5.3 indicate that electrical bioeffects can be effectively isolated from e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a7b4b19b37f598eb0965023d4056553
https://doi.org/10.1109/imbioc.2018.8428916

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