Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Gary L. Petzold"'
Publikováno v:
Analytical Biochemistry. 275:141-147
A sensitive fluorescence resonance energy transfer method was developed for the direct measurement of the dissociation constants of stromelysin inhibitors. The method is applied to the thiadiazole class of stromelysin inhibitors and it takes advantag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cc78230893307a4b21c46dd3a93617
https://doi.org/10.1006/abio.1999.4306
https://doi.org/10.1006/abio.1999.4306
Autor:
S. Gilbertson-Beadling, E.A. Powers, Gary L. Petzold, Roger A. Poorman, C. Fisher, Mark A. Mitchell
Publikováno v:
Developmental Biology. 162:499-510
Human umbilical vein endothelial cells (HUVECs) invade collagen gels and establish vascular-like structures within the gel following stimulation with phorbol esters. This process was quantitated by measuring release of radio-activity from gels compos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bb4d23096bd81dd145707eaa77cf2a
https://doi.org/10.1006/dbio.1994.1104
https://doi.org/10.1006/dbio.1994.1104
Autor:
Randy M. Jensen, Nanda D. Brahme, Gary L. Petzold, Wendell Wierenga, David H. Swenson, Nicole T. Hatzenbuhler, Terrence A. Scahill
Publikováno v:
Biochemistry. 29:2852-2860
The binding of the antitumor drug CC-1065 has been studied with nuclear magnetic resonance (NMR) spectroscopy. This study involves two parts, the elucidation of the covalent binding site of the drug to DNA and a detailed investigation of the noncoval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426efda3172ca9a1f1a2743da162af27
https://doi.org/10.1021/bi00463a031
https://doi.org/10.1021/bi00463a031
Autor:
E. Jon Jacobsen, Mark A. Mitchell, Susan K. Hendges, Kenneth L. Belonga, Louis L. Skaletzky, Lindsay S. Stelzer, Thomas. J. Lindberg, Edward L. Fritzen, Heinrich J. Schostarez, Theresa J. O'Sullivan, Linda L. Maggiora, Christopher W. Stuchly, Alice L. Laborde, Marc F. Kubicek, Roger A. Poorman, Joan M. Beck, Henry R. Miller, Gary L. Petzold, Pam S. Scott, Scott E. Truesdell, Tanya L. Wallace, John W. Wilks, Christopher Fisher, Linda V. Goodman, Paul S. Kaytes, Stephen R. Ledbetter, Elaine A. Powers, Gabriel Vogeli, John E. Mott, Catherine M. Trepod, Douglas J. Staples, Eric T. Baldwin, Barry C. Finzel
Publikováno v:
Journal of medicinal chemistry. 42(9)
The synthesis and enzyme inhibition data for a series of thiadiazole urea matrix metalloproteinase (MMP) inhibitors are described. A broad screening effort was utilized to identify several thiadiazoles which were weak inhibitors of stromelysin. Optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3630f045f8e5be4e4fb6f1d8e5cd0e65
https://pubmed.ncbi.nlm.nih.gov/10229623
https://pubmed.ncbi.nlm.nih.gov/10229623
Publikováno v:
Journal of protein chemistry. 17(7)
The active site of the catalytic domain of stromelysin-1 (matrix metalloproteinase-3, MMP-3) was probed by fluorescence quenching, lifetime, and polarization of its three intrinsic tryptophans and by the environmentally sensitive fluorescent reporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2b9d904e75086df07fa35413a200bc
https://pubmed.ncbi.nlm.nih.gov/9853686
https://pubmed.ncbi.nlm.nih.gov/9853686
Autor:
Robert C. Kelly, Wicnienski Nancy Anne, David R. Siemieniak, Jerry L. Slightom, Gary L. Petzold, Nicole T. Hatzenbuhler, Mark A. Mitchell, Marta G. Williams
Publikováno v:
Journal of the American Chemical Society. 113:8994-8995
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47ff8f0efa16e7f184eb327d330deba
https://doi.org/10.1021/ja00023a085
https://doi.org/10.1021/ja00023a085
Autor:
David H. Swenson, L. H. Li, Gary L. Petzold, Mark D. Prairie, A. Moscowitz, William C. Krueger, D.J. Duchamp
Publikováno v:
Chemico-Biological Interactions. 59:55-72
In this work, we report on the binding of the novel antitumor agent CC-1065 to poly(dA).poly(dT) and to mixtures of dA and dT oligomers as determined by electronic absorption and circular dichroism (CD) methods. In addition, the DNA binding propertie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af03d9990302fe00aff0a8ae3c7d6d2
https://doi.org/10.1016/s0009-2797(86)80055-2
https://doi.org/10.1016/s0009-2797(86)80055-2
Publikováno v:
Cancer Letters. 33:75-81
To investigate the hypothesis that the similarity of dose-response curves for induction of thymic lymphoma in C57BL mice was due to similar DNA alkylation profiles for 1-ethyl-1-nitrosourea (ENU) and 1-(2-hydroxyethyl)-1-nitrosourea (HNU), we measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8bcf8e05f8d8287898c242d554f0ad
https://doi.org/10.1016/0304-3835(86)90103-5
https://doi.org/10.1016/0304-3835(86)90103-5
Autor:
Mark D. Prairie, L. H. Li, David H. Swenson, Gary L. Petzold, William C. Krueger, Marta G. Williams
Publikováno v:
Chemico-Biological Interactions. 67:199-213
The factors influencing the binding of CC-1065 to DNA were examined using racemic analogs with varying chain lengths. The ability of these agents to bind DNA appeared to be related to cytotoxic potency, however this did not appear to be a direct quan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f440f00169f65575b03136b6d0fbc8db
https://doi.org/10.1016/0009-2797(88)90058-0
https://doi.org/10.1016/0009-2797(88)90058-0
Publikováno v:
Journal of Biological Chemistry. 248:179-189
Two adenosine 3',5'-monophosphate (cyclic AMP)-dependent protein kinases, with sedimentation coefficients of 5.4 S (mol wt 84,000) and 7.7 S (mol wt 140,000), respectively, have been purified from bovine brain. Each enzyme migrated as a single band a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3738129decf4ed1a32b3ff0210bcd5c3
https://doi.org/10.1016/s0021-9258(19)44460-8
https://doi.org/10.1016/s0021-9258(19)44460-8