Výsledky vyhledávání - "Gary L. Kieft"

Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon

Autor: Amer Abouhamze, Jill Gasser, Lyle L. Moldawer, J. Frazier, Tadahiko Kohno, Angela Nelson, Carl K. Edwards, Steven W. Martin, William J. Boyle, James Ervin Seely, Olaf B Kinstler, Gary L. Kieft, Jeff Rose, Jason J. Rosenberg, Kunitaro Fukuzuka, William Marshall, Gregory C. Gaines, Ulrich Feige, Judy St. Clair

Publikováno v: Journal of Applied Physiology. 91:2213-2223

Pharmacokinetics and immunogenicity of six different recombinant human soluble p55 tumor necrosis factor (TNF) receptor I (sTNFR-I) constructs were evaluated in juvenile baboons. The constructs included either an sTNFR-I IgG1 immunoadhesin (p55 sTNFR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3909cbf54a0553b797ee5d83f81f68
https://doi.org/10.1152/jappl.2001.91.5.2213

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Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats

Autor: J. Mccomb, Carl K. Edwards, J. Frazier, E. S. Chlipala, Gary L. Kieft, Alison M. Bendele, T. Gould, J. Wolf, James Ervin Seely

Publikováno v: Inflammation Research. 48:453-460

Objective: To determine the potential combination benefit receptor of treatment with PEGylated soluble tumor necrosis factor type I (PEG sTNF-RI) and dexamethasone (dex) or indomethacin (indo) in adjuvant arthritic rats.¶Subjects: 160 male Lewis Rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4a4c06a9e3a738e071653ede4ca61e
https://doi.org/10.1007/s000110050486

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Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon

Autor: Amer Abouhamze, Riadh Ksontini, Deborah Trujillo, J. Frazier, Tadahiko Kohno, Paul D. Edwards, Gary L. Kieft, Carmen C. Solorzano, Sherry McDaniel, Lyle L. Moldawer, Steven W. Martin, Carl K. Edwards, James Ervin Seely, Michael J. Clare-Salzler, Atsushi Kaibara, Phillip J. Hess, Sally L. D. MacKay, Mary Ellen Cosenza

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985). 84(4)

Immunogenicity, pharmacokinetics, and therapeutic efficacy of three novel dimeric soluble tumor necrosis factor (TNF)-receptor I constructs [TNF-binding protein (bp)] were evaluated in 28 baboons, 12 of which were healthy and 16 were challenged with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ce5c638df51f58fa5393e146b9294
https://pubmed.ncbi.nlm.nih.gov/9516174

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INVOLVEMENT OF fas AND fasL IN LPS OR S. ENTEROTOXIN B/D-GALACTOSAMINE-INDUCED LETHALITY USING fas MUTANT MRL-lpr/lpr and MRL-+/+ MICE

Autor: Gary L. Kieft, J St. Clair, Lyle L. Moldawer, Carl K. Edwards, Riadh Ksontini, Tong Zhou, C Elias, D B Colagiovanni, J D Mountz, Tadahiko Kohno, R J Evans

Publikováno v: Shock. 7:17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bba99acbf68c7fdc4592120447bdbcc1
https://doi.org/10.1097/00024382-199703001-00068

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Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA

Autor: Thomas R. Cech, Jeffrey R. Kent, Eric L. Sievers, James V. Price, Gary L. Kieft

Publikováno v: Nucleic acids research. 13(6)

The sequence requirements for splicing of the Tetrahymena pre-rRNA have been examined by altering the rRNA gene to produce versions that contain insertions and deletions within the intervening sequence (IVS). The altered genes were transcribed and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd82d5b94dcd27e7727f29d8413f350
https://pubmed.ncbi.nlm.nih.gov/4000946

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