Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Gary L Aistrup"'
Autor:
Alicia A Barnes, Zachary E Williams, Samuel Olzcyk, Alida Cooke, Jonathan A Cordeiro, Tanya Zeina, Rueben Mathew, Jacqueline A Treat, Gary L Aistrup, Jonathan M Cordeiro
Publikováno v:
Heart and Mind, Vol 3, Iss 2, Pp 63-69 (2019)
Background: A loss of t-tubules and alterations in ultrastructure occur in cultured ventricular myocytes. A similar alteration in t-tubules and ultrastructure is well documented under certain pathological conditions such as heart failure. We examined
Externí odkaz:
https://doaj.org/article/9c6749ce55d1460eb51658dd49e04d2f
Autor:
Gary L Aistrup, Ryan Pfeiffer, Robert Goodrow, Jon Cordeiro, Adife G Ercan-Sencicek, Mayuri Desai, Maria Kontaridis
Publikováno v:
Circulation Research. 131
Cardiac arrhythmias are responsible for 200-300 thousand deaths/year. Despite considerable research effort, much remains to be elucidated concerning the underlying mechanisms of arrhythmogenesis. Mutations in transient receptor potential melastatin 4
Autor:
Yohannes Shiferaw, Rishi Arora, Mona Dasgupta, Juliet Ryan, Rishi Modi, Daniel Wu, Lauren Nelson, Havisha Pedamallu, Caitlin O’Callaghan, Sean Yamakawa, Amy Burrell, Michael Frisk, William E Louch, Sanjiv J. Shah, Gary L. Aistrup, William Marszalec, J. Andrew Wasserstrom, Binita Gupta, Maryam Mufti, Junlan Zhou, Madeleine Chow
Publikováno v:
Am J Physiol Heart Circ Physiol
The goal of this work was to investigate the role of t-tubule (TT) remodeling in abnormal Ca(2+) cycling in ventricular myocytes of failing dog hearts. Heart failure (HF) was induced using rapid right ventricular pacing. Extensive changes in echocard
Autor:
Rod S. Passman, Suzanne Bull, Anna Pfenniger, Shin Yoo, Jacob Hoffman, Jason Ng, J. Andrew Wasserstrom, Rishi Arora, David A. Johnson, Brandon C. Benefield, Gary L. Aistrup, Amy Burrell, Bradley P. Knight, Georg Gussak, Trent Waugh, Wenwei Zhang
Publikováno v:
Circulation
Background: Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments of AF are suboptimal because they are not targeted to the molecular mechanisms underlying AF. Using
Autor:
Junlan Zhou, Neha Singh, Chloe Monnier, William Marszalec, Li Gao, Jing Jin, Michael Frisk, William E. Louch, Suresh Verma, Prasanna Krishnamurthy, Elsa Nico, Maaz Mulla, Gary L. Aistrup, Raj Kishore, J. Andrew Wasserstrom
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
BIN1 (amphyphysin-II) is a structural protein involved in T-tubule (TT) formation and phosphatidylinositol-4,5-bisphosphate (PIP2) is responsible for localization of BIN1 to sarcolemma. The goal of this study was to determine if PIP2-mediated targeti
Autor:
Samuel Olzcyk, Rueben Mathew, Zachary E Williams, Jonathan A. Cordeiro, Jonathan M. Cordeiro, Alicia A Barnes, Alida Cooke, Gary L. Aistrup, Jacqueline A. Treat, Tanya Zeina
Publikováno v:
Heart and Mind, Vol 3, Iss 2, Pp 63-69 (2019)
Background: A loss of t-tubules and alterations in ultrastructure occur in cultured ventricular myocytes. A similar alteration in t-tubules and ultrastructure is well documented under certain pathological conditions such as heart failure. We examined
Autor:
Lothar A. Blatter, Georg Gussak, Yohannes Shiferaw, Rishi Arora, Shin Yoo, Caitlin O’Callaghan, Junlan Zhou, Jonathan M. Cordeiro, Gary L. Aistrup, Robert J. Goodrow, Amy Burrell, William Marszalec, Giedrius Kanaporis, J. Andrew Wasserstrom, Rishi Modi
Publikováno v:
Circ Arrhythm Electrophysiol
Background: We have identified a novel form of abnormal Ca 2+ wave activity in normal and failing dog atrial myocytes which occurs during the action potential (AP) and is absent during diastole. The goal of this study was to determine if triggered Ca
Autor:
Rod S. Passman, Jeffrey J. Goldberger, Shin Yoo, Amy Burrell, Georg Gussak, David A. Johnson, Anna Pfenniger, Bradley P. Knight, Yohannes Shiferaw, Lisa Wren, J. Andrew Wasserstrom, Mehul Gilani, Wenwei Zhang, Gabriel M. Knight, Rishi Arora, Brandon C. Benefield, Gary L. Aistrup
Publikováno v:
JCI Insight. 4
Atrial fibrillation (AF) is the most common heart rhythm disorder and a major cause of stroke. Unfortunately, current therapies for AF are suboptimal, largely because the molecular mechanisms underlying AF are poorly understood. Since the autonomic n
Autor:
Long-Sheng Song, Jasleen Singh, Ang Guo, Shannon Tai, Caleb Frank, Rishi Arora, Stephen Supple, Gary L. Aistrup, J. Andrew Wasserstrom, Anne Zhao, Laura Chicos, William Marszalec
Publikováno v:
Heart Rhythm. 14:273-281
The peculiarities of transverse tubule (T-tubule) morphology and distribution in the atrium-and how they contribute to excitation-contraction coupling-are just beginning to be understood.The objectives of this study were to determine T-tubule density
Autor:
Anna Pfenniger, Georg Gussak, Trent Waugh, Rod S. Passman, Jason Ng, Amy Burrell, David A. Johnson, Bradley P. Knight, Wenwei Zhang, Suzanne Bull, J. Andrew Wasserstrom, Rishi Arora, Brandon C. Benefield, Gary L. Aistrup, Shin Yoo, Jacob Hoffman
Atrial fibrillation is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments of AF are suboptimal as they are not targeted to the molecular mechanisms underlying AF. In this study, we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248b4443737e4bff43dc1fd733a282cc
https://doi.org/10.1101/765008
https://doi.org/10.1101/765008