Výsledky vyhledávání - "Gary K. Geiss"

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Autor: Joseph M. Beechem, Lawrence D. True, Ilsa Coleman, Lauren Brady, Peter S. Nelson, Martine Roudier, Roman Gulati, Rhonda Meredith, Michelle Kriner, Gary K. Geiss, Zoey Zhou, Colm Morrissey, Margaret L. Hoang, Stephen R. Plymate, Brian Birditt

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established. Here we use digital spatial profiling (DSP) technology to quantitate transcript and protein a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1ce751d896a52a32d0b48b8b2a9317
https://doi.org/10.1038/s41467-021-21615-4

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Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies

Autor: Joseph M. Beechem, Yiling Lu, Huifang Guo, Lisa Y. Bogatzki, Rhonda Meredith, Savitri Krishnamurthy, Jinho Lee, Gordon B. Mills, Christopher P. Vellano, Shuangxing Yu, Gary K. Geiss, Zhiyong Ding, Warren Carter, Gokhan Demirkan, Zhenlin Ju, Brian Filanoski

Publikováno v: Molecular & Cellular Proteomics. 17:1245-1258

Molecular analysis of tumors forms the basis for personalized cancer medicine and increasingly guides patient selection for targeted therapy. Future opportunities for personalized medicine are highlighted by the measurement of protein expression leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d3a771104a9453912c7b12053f5c1d
https://doi.org/10.1074/mcp.ra117.000291

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Multiplex digital spatial profiling of proteins and RNA in fixed tissue

Publikováno v: Nature biotechnology. 38(5)

Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded (FFPE) samples. The approach relies on (1) multiplexed readout of proteins or RNAs using olig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7e9422feb61c48fd0dc6bae263eb3b
https://pubmed.ncbi.nlm.nih.gov/32393914

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High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods

Autor: Chris Merritt, Charles Warren, Joseph M. Beechem, Dwayne Dunaway, Sarah Warren, Yan Liang, Sarah E. Church, Giang T. Ong, Jaemyeong Jung, Gary K. Geiss, Isaac Sprague, Gordon B. Mills, Kristina Sorg, Kristi Barker, Karen Nguyen, Daniel R. Zollinger, Zoey Zhou, Jill McKay-Fleisch, Margaret L. Hoang

We have developed Digital Spatial Profiling (DSP), a non-destructive method for high-plex spatial profiling of proteins and RNA, using oligonucleotide detection technologies with unlimited multiplexing capability. The key breakthroughs underlying DSP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48681149391a370bb1dcb76c7a7c468

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Abstract 1511: MEK activation modulates immunosuppressive MDSCs and metabolic phenotypes in TNBC

Autor: Douglas Hinerfeld, Paula I. Ericsson-Gonzalez, Rebecca S. Cook, Violeta Sanchez, Jehovana Orozco Bender, Jennifer Bordeaux, Phillip T. Dean, Derek A. Franklin, Susan R. Opalenik, Melinda E. Sanders, Michael T. Lewis, Christine Vaupel, Jenny C. Chang, Melissa C. Skala, Joe T. Sharick, Jean-Gabriel Judde, Justin M. Balko, Stefano Cairo, Gary K. Geiss

Publikováno v: Cancer Research. 79:1511-1511

Triple-negative breast cancers (TNBCs) are highly heterogeneous and aggressive, with high mortality rates. Although TNBC is typically more responsive to chemotherapy than other breast cancer subtypes, many patients develop chemo-resistance. The molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::262fbf9322966da75c53d5ea5c54f462
https://doi.org/10.1158/1538-7445.am2019-1511

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Abstract 146: Multiple modalities of NanoString GeoMx™ Digital Spatial Profiler allow for spatially-resolved, multiplexed quantification of protein and mRNA distribution and abundance

Autor: Joseph M. Beechem, Elena Viboch, Giang T. Ong, Gokhan Demirkan, Chris Merritt, Dwayne Dunaway, Kristina Sorg, Kristi Zevin, Gary K. Geiss, Lindy Irving

Publikováno v: Cancer Research. 79:146-146

Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues enables a better understanding of biological systems in many research areas, including immunology and oncology. However, it has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::489749dfba94cc965b6ae39f62fdbe12
https://doi.org/10.1158/1538-7445.am2019-146

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Spatially-resolved, multiplexed quantification of protein and mRNA distribution and abundance in colorectal cancer tumor microenvironment with multiple modalities of NanoString GeoMx Digital Spatial Profiler

Autor: Giang T. Ong, Douglas Hinerfeld, Kristina Sorg, Joseph M. Beechem, Gayathri Balasundaram, Gary K. Geiss, Gokhan Demirkan, Chris Merritt, Dwayne Dunaway

Publikováno v: Journal of Clinical Oncology. 37:e14218-e14218

e14218 Background: Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues enables a better understanding of biological systems in many research areas, including immunology and oncolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4288b5259b754a68cb3c64883a51ebcb
https://doi.org/10.1200/jco.2019.37.15_suppl.e14218

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