Symptom improvement in dry eye subjects following intranasal tear neurostimulation: Results of two studies utilizing a controlled adverse environment

Autor: David A Hollander, Michelle Senchyna, Mark Holdbrook, Guruprasad R. Pattar, David G. Evans, Gail Torkildsen, George W Ousler, Gary Jerkins

Publikováno v: The Ocular Surface. 18:249-257

To evaluate the safety and effectiveness of the intranasal tear neurostimulator (ITN) in improving dry eye symptoms assessed in a controlled adverse environment (CAE®).Study 1: Multicenter, subject-masked, randomized-sequence, crossover design. Sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fddfd59c486ded31acd3f0c41b777f
https://doi.org/10.1016/j.jtos.2019.09.006

A Randomized Phase 2 Trial Comparing Omidenepag Isopropyl 0.002% Once and Twice Daily in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension (SPECTRUM-6)

Autor: Noriko Odani-Kawabata, Michelle Sato, Phillip Dinh, Marc A Abrams, Fenghe Lu, Kenneth Olander, Almira Chabi, Gary Jerkins, Naveed K Shams

Publikováno v: Journal of Glaucoma

Prcis No significant difference was found between the intraocular pressure (IOP) lowering of omidenepag isopropyl 0.002% once daily (QD) and twice daily (BID). However, adverse events (AEs) were higher in the BID arm; thus, QD dosing is the preferred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2fd8b013e3f4733e4d132b49834a4a
https://pubmed.ncbi.nlm.nih.gov/33813559

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1)

Autor: Felipe A. Medeiros, Thomas R. Walters, Miriam Kolko, Michael Coote, Marina Bejanian, Margot L. Goodkin, Qiang Guo, Jane Zhang, Michael R. Robinson, Robert N. Weinreb, Ashish Agar, Renuka Bathijia, Lance Liu, Tim Roberts, Christoph Faschinger, Clemens Vass, Nathalie Collignon, Ana Claudia Alves Pereira, Rubens Belfort de Mattos, Fernando Justino Dantas, Marcelo Jordao Lopes da Silva, Fabio Kanadani, Leopoldo Magacho dos Santos Silva, Tiago Prata, Daniella Bach-Holm, Jimmy Lai, Clement Tham, György Bátor, Lajos Szalczer, Balázs Varsányi, Eytan Blumenthal, Orna Geyer, Shmuel Lavartovsky, Tamar Pedut-Kloizman, Nir Shoham-Hazon, Silvio Lujan, Benjamin Abela, Robert E. Ang, Edgar U. Leuenberger, Harvey Uy, Maria Imelda Yap-Veloso, Piotr Fryczkowski, Piotr Jurowski, Bartlomiej Kalużny, Józef Kalużny, Marta Misiuk-Hojlo, Krystyna Raczynska, Wioletta Tomczyk-Dorozynska, Jaromir Wasyluk, Slawomir Zalewski, Tomasz Zarnowski, Julian Garcia Feijoó, Rafael Giménez-Gómez, Elena Milla Griño, Alfonso Antón López, Merce Guarro Miralles, Javier Montero Moreno, Vicente Polo, Enrique Cervera Taulet, Beatriz Ponte Zúñiga, Ying-Ying Chen, Yuan-Chieh Lee, Louis Alpern, Michael S. Berlin, Jacob Brubaker, Delmar Caldwell, Andrew Camp, Louis B. Cantor, Ronald Caronia, Charles J. Crane, Douglas Day, Eran Duzman, John Elfervig, Sherif El-Harazi, Richard Evans, Ann C. Fisher, William John Flynn, Charles Stephen Foster, Ronald Frenkel, Raj Goyal, Ronald Gross, Paul J. Hartman, William L. Haynes, Gary Jerkins, Janet Kim, Max Kim, Bradley Kwapiszeski, Benjamin Lambright, Christine Larsen, James Lehmann, Jeffrey H. Levenson, Dwayne Logan, Brian McMillan, Joseph R. Martel, Hylton Mayer, Felipe Medeiros, Sayoko Moroi, Andrew Moyes, Jonathan Myers, John Nairn, Steven Nielsen, Don Perez Ortiz, James Paauw, Vicky Pai, Joseph Panarelli, Abraham Park, Mujtaba A. Qazi, Nikola Ragusa, Douglas J. Rhee, Robert Rothman, Reginald Sampson, Samuel Seltzer, Anurag Shrivastava, Steven T. Simmons, Annette Sims, Mark A. Slabaugh, Scott Smetana, Oluwatosin Smith, Scott C. So, Ingeborg Stalmans, Jitendra Swarup, Jay Wallshein, Fiaz Zaman, Rui Zhang

Publikováno v: Medeiros, F A, Walters, T R, Kolko, M, Coote, M, Bejanian, M, Goodkin, M L, Guo, Q, Zhang, J, Robinson, M R, Weinreb, R N, ARTEMIS 1 Study Group, Agar, A, Coote, M, Bathijia, R, Bach-Holm, D, Walters, T R, Zaman, F & Zhang, R 2020, ' Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1) ', Ophthalmology, vol. 127, no. 12, pp. 1627-1641 . https://doi.org/10.1016/j.ophtha.2020.06.018

Purpose To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations. Design Randomiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6460ae378d48f231ab7646dd34d2e2a
https://pubmed.ncbi.nlm.nih.gov/32544560

Clinical Outcomes of Fixed Versus As-Needed Use of Artificial Tears in Dry Eye Disease: A 6-Week, Observer-Masked Phase 4 Clinical Trial

Autor: Jacqueline Tan, Lee Shettle, Abayomi Ogundele, Penny A. Asbell, Laura E Downie, Algis J. Vingrys, Gary Jerkins

Publikováno v: Investigative Opthalmology & Visual Science. 59:2275

Purpose: To evaluate the clinical effects of using fixed (four times daily [QID]) versus as-needed (PRN) dosing of an artificial tear product (polyethylene glycol/propylene glycol [PEG/PG]; Systane Ultra) in individuals with dry eye disease. Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f331b65cb8e151aa279c300537ee1b38
https://doi.org/10.1167/iovs.17-23733