Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gary J. Spencer"'
Autor:
Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109725- (2021)
Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophag
Externí odkaz:
https://doaj.org/article/03d3a10c03eb467b9558377392816f96
Autor:
Alba Maiques-Diaz, Gary J. Spencer, James T. Lynch, Filippo Ciceri, Emma L. Williams, Fabio M.R. Amaral, Daniel H. Wiseman, William J. Harris, Yaoyong Li, Sudhakar Sahoo, James R. Hitchin, Daniel P. Mould, Emma E. Fairweather, Bohdan Waszkowycz, Allan M. Jordan, Duncan L. Smith, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 22, Iss 13, Pp 3641-3659 (2018)
Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity.
Externí odkaz:
https://doaj.org/article/62c57f81e288426abeec246fcdba9441
Autor:
Tim D.D. Somerville, Fabrizio Simeoni, John A. Chadwick, Emma L. Williams, Gary J. Spencer, Katalin Boros, Christopher Wirth, Eleni Tholouli, Richard J. Byers, Tim C.P. Somervaille
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 638-652 (2018)
The Iroquois homeodomain transcription factor gene IRX3 is expressed in the developing nervous system, limb buds, and heart, and transcript levels specify obesity risk in humans. We now report a functional role for IRX3 in human acute leukemia. Altho
Externí odkaz:
https://doaj.org/article/4afa71a0ca914ca1a316ea4f6f7850b2
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 4 (2018)
Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transc
Externí odkaz:
https://doaj.org/article/54c03ffaaa5844b88e4542acc79a378c
Autor:
Alba Maiques-Diaz, Luciano Nicosia, Naseer J. Basma, Isabel Romero-Camarero, Francesco Camera, Gary J. Spencer, Fabio M. R. Amaral, Fabrizio Simeoni, Bettina Wingelhofer, Andrew J. K. Williamson, Andrew Pierce, Anthony D. Whetton, Tim C. P. Somervaille
Publikováno v:
Oncogene. 41:4841-4854
Pharmacologic inhibition of LSD1 induces molecular and morphologic differentiation of blast cells in acute myeloid leukemia (AML) patients harboring MLL gene translocations. In addition to its demethylase activity, LSD1 has a critical scaffolding fun
Autor:
Luciano Nicosia, Gary J Spencer, Nigel Brooks, Fabio Amaral, Naseer Basma, John Chadwick, Bradley Revell, Bettina Wingelhofer, Alba Maiques-Diaz, Filippo Ciceri, Daniel H Wiseman, Neil A Pegg, William West, Tomasz Knurowski, Kris Frese, Karen Clegg, Victoria Louise Campbell, Mhairi Copland, Emma Searle, Tim C.P Somervaille
Publikováno v:
Blood. 140:8774-8775
Autor:
Georges Lacaud, Jason S. Carroll, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Daniel H. Wiseman, Isabel Romero-Camarero, Tim C. P. Somervaille, Francesco Camera, Fabio M. R. Amaral, Fabrizio Simeoni, Michael Lie-A-Ling
Publikováno v:
Cell Reports
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Cell Reports, Vol 36, Iss 12, Pp 109725-(2021)
Summary Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage
Autor:
Gary J. Spencer, Karen Clegg, Andrew Hughes, Tim C. P. Somervaille, John A. Chadwick, William H. West, Nigel Brooks, Tomasz Knurowski, Neil Anthony Pegg
Publikováno v:
Blood. 138:3291-3291
E1A binding protein (p300) and CREB binding protein (CBP) are two closely related histone acetyl transferases that co-activate key oncogenes such as MYC and IRF4 which are relevant in a number of haematological malignancies. Here we describe the effe
Autor:
Ulf Bremberg, Donald J. Ogilvie, Matthis Geitmann, Gary J. Spencer, Allan M. Jordan, Alison E. McGonagle, Daniel P. Mould, Tim C. P. Somervaille
Publikováno v:
Mould, D, Bremberg, U, Jordan, A, Geitmann, M, Mcgonagle, A, Somervaille, T, Spencer, G & Ogilvie, D 2017, ' Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1 ', Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 20, pp. 4755-4759 . https://doi.org/10.1016/j.bmcl.2017.08.052
As part of our ongoing efforts to develop reversible inhibitors of LSD1, we identified a series of 4-(pyrrolidin-3-yl)benzonitrile derivatives that act as successful scaffold-hops of the literature inhibitor GSK-690. The most active compound, 21g, de
Autor:
Gary J. Spencer, Ulf Bremberg, Matthis Geitmann, Allan M. Jordan, Sharon Cartic, Alison E. McGonagle, Daniel P. Mould, Fabrice Turlais, Donald J. Ogilvie, Tim C. P. Somervaille, Cristina Alli, Alba Maiques-Diaz
Publikováno v:
Mould, D, Alli, C, Bremberg, U, Cartic, S, Jordan, A, Geitmann, M, Maiques-Diaz, A, Mcgonagle, A, Somervaille, T, Spencer, G, Turlais, F & Ogilvie, D 2017, ' Development of (4-Cyanophenyl)glycine Derivatives as Reversible Inhibitors of Lysine Specific Demethylase 1 ', Journal of Medicinal Chemistry . https://doi.org/10.1021/acs.jmedchem.7b00462
Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the differentiation of leukemia stem cells in acute myeloid leukaemia (AML). Irreversible inhibitors developed from the non-specific inhibitor tranylcypromine have entered cl