Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Gary J. Schwartz"'
Autor:
Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic n
Externí odkaz:
https://doaj.org/article/fe3b417b3e654fd0a95ad82351d23a97
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Externí odkaz:
https://doaj.org/article/bf167ffa54e9445c9193b19ae5fc11f8
Autor:
Shunmei Liu, Genevieve Marcelin, Clemence Blouet, Jae Hoon Jeong, Young-Hwan Jo, Gary J. Schwartz, Streamson Chua, Jr.
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 37-50 (2018)
Objective: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons.
Externí odkaz:
https://doaj.org/article/dfa97d425c01435aa865982a75668b1b
Autor:
John T. Garretson, Laura A. Szymanski, Gary J. Schwartz, Bingzhong Xue, Vitaly Ryu, Timothy J. Bartness
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 626-634 (2016)
Objective: Metabolic challenges, such as a cold environment, stimulate sympathetic neural efferent activity to white adipose tissue (WAT) to drive lipolysis, thereby increasing the availability of free fatty acids as one source of fuel for brown adip
Externí odkaz:
https://doaj.org/article/ffb5eead0023466f9a8175609c2b3bbe
Autor:
Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo
Publikováno v:
Molecular Metabolism, Vol 4, Iss 6, Pp 483-492 (2015)
Objective: Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function and synap
Externí odkaz:
https://doaj.org/article/17d1ab3d576446ffb2680a5dec743953
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 964-972 (2012)
Dissecting the genetics of complex traits such as obesity allows the identification of causal genes for disease. Here, we show that the BALB/c mouse strain carries genetic variants that confer resistance to obesity induced by leptin-deficiency or a h
Externí odkaz:
https://doaj.org/article/817ca8fb41794c69a2050226300487a7
Autor:
Jahangir Iqbal, Xiaosong Li, Benny Hung-Junn Chang, Lawrence Chan, Gary J. Schwartz, Streamson C. Chua, Jr., M. Mahmood Hussain
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1929-1942 (2010)
Fat is delivered to tissues by apoB-containing lipoproteins synthesized in the liver and intestine with the help of an intracellular chaperone, microsomal triglyceride transfer protein (MTP). Leptin, a hormone secreted by adipose tissue, acts in the
Externí odkaz:
https://doaj.org/article/4f525c3e5c6c49138dbb00215678677c
Autor:
Huidong Shi, Gary J. Schwartz, Fenfen Li, Bingzhong Xue, Shirong Wang, Rui Wu, Liqing Yu, Jia Jing, Xin Cui, Qiang Cao, Ke Li, Hang Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis. Here we discover a fat-derived “adipokine” neurotrophic factor neurot
Autor:
Gary J. Schwartz, Rogerio O. Batista, Natalie R. Lopatinsky, Marko Kraljević, Caroline S. Jiang, Amanda S. Dirnberger, Ana B. Emiliano
Although sleeve gastrectomy (SG) is the most commonly performed bariatric surgery in the US, its mechanistic underpinnings have not been fully determined. Thus, we set out to investigate whether SG’s effects on the peripheral sympathetic system cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943a5465fe73c8fdc136a49fbb2c7dbc
https://doi.org/10.1101/2022.10.17.512615
https://doi.org/10.1101/2022.10.17.512615
Autor:
Ana B. Emiliano, Natalie R. Lopatinsky, Marko Kraljević, Sei Higuchi, Ying He, Rebecca A. Haeusler, Gary J. Schwartz
Publikováno v:
Am J Physiol Endocrinol Metab
Despite the high prevalence of obesity among middle-aged subjects, it is unclear if sex differences in middle age affect the metabolic outcomes of obesity therapies. Accordingly, in this study, middle-aged obese female and male mice were randomized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e53b80a0a489fd2450ef5887d33443
https://europepmc.org/articles/PMC9273270/
https://europepmc.org/articles/PMC9273270/