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pro vyhledávání: '"Gary J. Mack"'
Autor:
Gary J. Mack, Duane A. Compton
Publikováno v:
Proceedings of the National Academy of Sciences. 98:14434-14439
We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated protein by using mass spectrometry. Most of these proteins are known spindle-associated components with essential functiona
Publikováno v:
Microscopy Research and Technique. 49:409-419
The centrosome found in animal cells is a complex and dynamic organelle that functions as the major microtubule organizing center. Structural studies over the past several decades have defined the primary structural features of the centrosome but rec
Autor:
Cornel Popovici, Gary J. Mack, Jerome B. Rattner, Marie-Josèphe Pébusque, Daniel Birnbaum, Géraldine Guasch, Nicole Dastugue
Publikováno v:
Blood. 95:1788-1796
The hallmark of the 8p12 stem cell myeloproliferative disorder (MPD) is the disruption of the FGFR1 gene, which encodes a tyrosine kinase receptor for members of the fibroblast growth factor family.FGFR1 can be fused to at least 3 partner genes at ch
Autor:
Jerome B. Rattner, Marvin J. Fritzler, Jennifer Rees, Olof Sandblom, Ronald Balczon, Gary J. Mack
Publikováno v:
Arthritis & Rheumatism. 41:551-558
Objective Human autoantibodies reacting with protein components of the microtubule organizing center of the cell, the centrosome, are rare and have not been extensively studied. We therefore investigated the number, type, and frequency of autoantibod
Publikováno v:
Molecular Biology Reports. 25:143-155
Autoantibodies directed to a variety of cellular antigens and organelles are a feature of autoimmune diseases. They have proven useful in a clinical setting to establish diagnosis, estimate prognosis, follow disease progression, alter therapy, and in
Autor:
Gary J. Mack, Quansheng Du, Alexey Khodjakov, Duane A. Compton, O. P. Kisurina-Evgenieva, Ian G. Macara
Publikováno v:
Journal of cell science. 117(Pt 26)
The large coiled-coil protein NuMA plays an essential role in organizing microtubule minus ends at spindle poles in vertebrate cells. Here, we use both in vivo and in vitro methods to examine NuMA dynamics at mitotic spindle poles. Using fluorescence
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(8)
Yeast endoplasmic reticulum (ER) vesicle protein Erv46p is a novel membrane protein involved in transport through the early secretory pathway. Investigation of mammalian Erv46 (mErv46) reveals that it is broadly expressed in tissues and protein-secre
Publikováno v:
Journal of cell science. 115(Pt 9)
The mammalian centrosome consists of a pair of centrioles surrounded by pericentriolar material (PCM). The architecture and composition of the centrosome, especially the PCM, changes during the cell cycle. Recently, a subset of PCM proteins have been
Publikováno v:
Chromosoma. 101(10)
We have identified a novel M(r) 36,000 protein (MSA-36) that has a complex cell cycle dependent distribution. This protein is first detected in interphase nuclei just prior to the onset of chromosome condensation. MSA-36 is found along condensing chr
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 70(10-11)
We have identified a putative 35-kilodalton protein that colocalizes with microtubules and displays a unique spatial and temporal distribution during the cell cycle of HeLa cells. This protein has been given the designation MSA-35. MSA-35 first appea