Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Gary J. Kargacin"'
Autor:
Gary J. Kargacin, Emma J. Walsh, William C. Cole, Dylan M. Cole, X. Zoë Zhong, Olaia Colinas, Alejandro Moreno-Domínguez, Hai-Lei Zhu, Ahmed F. El-Yazbi, Michael P. Walsh
Publikováno v:
Journal of Biological Chemistry. 289:20939-20952
Our understanding of the molecular events contributing to myogenic control of diameter in cerebral resistance arteries in response to changes in intravascular pressure, a fundamental mechanism regulating blood flow to the brain, is incomplete. Myosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d55be3b6ecdc398db344fda7e2db4
https://doi.org/10.1074/jbc.m114.553743
https://doi.org/10.1074/jbc.m114.553743
Publikováno v:
British Journal of Pharmacology. 154:675-687
Background and purpose: Aldosterone plays a major role in cardiac pathology. This study was designed to investigate the role of cardiac aldosterone in modulating K+ currents and oxidative stress in the streptozotocin-induced diabetic rat heart. Exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6bb91c4c2e3eeba2a45a582366e470d
https://doi.org/10.1038/bjp.2008.114
https://doi.org/10.1038/bjp.2008.114
Autor:
Roozbeh Aschar-Sobbi, Margaret E. Kargacin, Robert J. French, Evgeny Pavlov, Gary J. Kargacin, Sanja Beca
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 457:121-135
Anion and cation channels present in the sarcoplasmic reticulum (SR) are believed to be necessary to maintain the electroneutrality of SR membrane during Ca(2+) uptake by the SR Ca(2+) pump (SERCA). Here we incorporated canine cardiac SR ion channels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52886820ed68b5709897f123f5c42d88
https://doi.org/10.1007/s00424-008-0510-9
https://doi.org/10.1007/s00424-008-0510-9
Autor:
Andrey Y. Abramov, Evgeny Pavlov, Margaret E. Kargacin, Gary J. Kargacin, Catherine Diao, Robert J. French, Roozbeh Aschar-Sobbi
Publikováno v:
Journal of Fluorescence. 18:859-866
Polyphosphate (poly-P) is an important metabolite and signaling molecule in prokaryotes and eukaryotes. DAPI (4',6-diamidino-2-phenylindole), a widely used fluorescent label for DNA, also interacts with polyphosphate. Binding of poly-P to DAPI, shift
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a3374b08a9f43afbf3c347d3a5ab4a
https://doi.org/10.1007/s10895-008-0315-4
https://doi.org/10.1007/s10895-008-0315-4
Autor:
Gary J. Kargacin, Ezequiel Morales, Kathy Loutzenhiser, Lisa Chilton, Rodger Loutzenhiser, Jennifer Breaks
Publikováno v:
Journal of the American Society of Nephrology. 19:69-76
The afferent and efferent arterioles regulate the inflow and outflow resistance of the glomerulus, acting in concert to control the glomerular capillary pressure and glomerular filtration rate. The myocytes of these two vessels are remarkably differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad19f12929e1767769160d3c588b39d8
https://doi.org/10.1681/asn.2007010039
https://doi.org/10.1681/asn.2007010039
Publikováno v:
The Journal of Physiology. 580:543-560
Diabetes mellitus is a growing epidemic with severe cardiovascular complications. Although much is known about mechanical and electrical cardiac dysfunction in diabetes, few studies have investigated propagation of the electrical signal in the diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c014a0f97ed05fda9bbf8cdc6484e53
https://doi.org/10.1113/jphysiol.2006.123729
https://doi.org/10.1113/jphysiol.2006.123729
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:921-929
The effects of the phytoestrogens phloretin and phloridzin on Ca(2+) handling, cell shortening, the action potential, and Ca(2+) and K(+) currents in freshly isolated cardiac myocytes from rat ventricle were examined. Phloretin increased the amplitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11931707b77ca46bcc36d5f28007a162
https://doi.org/10.1124/jpet.107.121111
https://doi.org/10.1124/jpet.107.121111
Autor:
Gary J. Kargacin, Teresa Emmett, Aniko Rokolya, Margaret E. Kargacin, Erwin Wirch, Michael P. Walsh, Gail A. McMartin, Mitsuo Ikebe, Donald J. Hunt
Publikováno v:
Archives of Biochemistry and Biophysics. 456:151-160
Telokin is identical in sequence to the C-terminal portion of myosin light chain kinase but is expressed independently. We have used monoclonal antibodies specific to the non-telokin portion of myosin light chain kinase and to telokin, immunofluoresc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e0e485ed60ba441a27b8bf61c36f44
https://doi.org/10.1016/j.abb.2006.06.018
https://doi.org/10.1016/j.abb.2006.06.018
Publikováno v:
Biophysical Journal. 91(2):433-443
The space between the t-tubule invagination and the sarcoplasmic reticulum (SR) membrane, the dyad, in ventricular myocytes has been predicted to experience very high [Ca2+] for short periods of time during a Ca2+ transient. The dyadic space accommod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a1f85ec51343d8b253bdcbe43568a4
Publikováno v:
The Journal of Physiology. 567:177-190
Diabetes induces oxidative stress and leads to attenuation of cardiac K+ currents. We investigated the role of superoxide ions and angiotensin II (ANG II) in generating and linking oxidative stress to the modulation of K+ currents under diabetic cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::871d343539d414212792ca3c6d12462d
https://doi.org/10.1113/jphysiol.2005.090639
https://doi.org/10.1113/jphysiol.2005.090639