Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Gary J. Iacobucci"'
Autor:
Gary J Iacobucci, Gabriela K Popescu
Publikováno v:
Calcium Signals ISBN: 9780750320092
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45716e72eb98c39ac6cfc8a9b45b4705
https://doi.org/10.1088/978-0-7503-2009-2ch4
https://doi.org/10.1088/978-0-7503-2009-2ch4
Ca2+-Dependent Inactivation of GluN2A and GluN2B NMDA Receptors Occurs by a Common Kinetic Mechanism
Autor:
Gabriela K. Popescu, Gary J. Iacobucci
Publikováno v:
Biophys J
N-Methyl-d-aspartate (NMDA) receptors are Ca(2+)-permeable channels gated by glutamate and glycine that are essential for central excitatory transmission. Ca(2+)-dependent inactivation (CDI) is a regulatory feedback mechanism that reduces GluN2A-type
Autor:
Gary J Iacobucci, Noura Abdel Rahman, Aida Andrades Valtueña, Tapan Kumar Nayak, Shermali Gunawardena
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97237 (2014)
Efficient intracellular transport is essential for healthy cellular function and structural integrity, and problems in this pathway can lead to neuronal cell death and disease. To spatially and temporally evaluate how transport defects are initiated,
Externí odkaz:
https://doaj.org/article/313a1616adf84239b2f9e9e1608196c6
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance NMDA receptors are glutamatergic channels whose activation controls the strength of excitatory synapses in the central nervous system. Agonist binding initiates a complex activation reaction that consists of a stepwise sequence of revers
Autor:
Hayley Hoffmar-Glennon, Layne Thurston, Joseph A. White, Shermali Gunawardena, Claire N. Thant, Katherine Zimmerman, Julia Vail, Saad Navid Rahman, Thomas J. Krzystek, Gary J. Iacobucci
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-22 (2020)
Huntington’s disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the huntingtin (HTT) gene. Both polyQ expansion and loss of HTT have been s
NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are of current interest. Ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196ca82ed7a8e851be0f2e1e898aeedf
https://doi.org/10.1101/2020.06.08.140525
https://doi.org/10.1101/2020.06.08.140525
Autor:
Farda Barandeh, Phuong-Lan Nguyen, Rajiv Kumar, Gary J Iacobucci, Michelle L Kuznicki, Andrew Kosterman, Earl J Bergey, Paras N Prasad, Shermali Gunawardena
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29424 (2012)
The application of nanotechnology in biological research is beginning to have a major impact leading to the development of new types of tools for human health. One focus of nanobiotechnology is the development of nanoparticle-based formulations for u
Externí odkaz:
https://doaj.org/article/85ef5c0d7d82403d890668b1644dbc49
Autor:
Gabriela K. Popescu, Gary J. Iacobucci
Publikováno v:
J Neurosci
In the CNS, NMDA receptors generate large and highly regulated Ca2+signals, which are critical for synaptic development and plasticity. They are highly clustered at postsynaptic sites and along dendritic arbors, but whether this spatial arrangement a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f53bee612490b9a776349f0f4e3f1e
https://europepmc.org/articles/PMC6832682/
https://europepmc.org/articles/PMC6832682/
Autor:
Gary J. Iacobucci, Gabriela K. Popescu
Publikováno v:
The Oxford Handbook of Neuronal Ion Channels ISBN: 9780190669164
Discovered more than 70 years ago due to advances in electrophysiology and cell culture techniques, N-methyl-D-aspartate (NMDA) receptors remain the target of assiduous basic and clinical research. This interest flows from their intimate engagement w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae223386a0b19e6ea739ca80da844450
https://doi.org/10.1093/oxfordhb/9780190669164.013.16
https://doi.org/10.1093/oxfordhb/9780190669164.013.16
Publikováno v:
Biophysical Journal. 112:2589-2601
N-Methyl-D-aspartate (NMDA) receptors are glutamate-gated excitatory channels that play essential roles in brain functions. High-resolution structures have been solved for an allosterically inhibited and agonist-bound form of a functional NMDA recept