Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gary J. Hoffman"'
Autor:
Julia Weber, Jorge de la Rosa, Carolyn S. Grove, Markus Schick, Lena Rad, Olga Baranov, Alexander Strong, Anja Pfaus, Mathias J. Friedrich, Thomas Engleitner, Robert Lersch, Rupert Öllinger, Michael Grau, Irene Gonzalez Menendez, Manuela Martella, Ursula Kohlhofer, Ruby Banerjee, Maria A. Turchaninova, Anna Scherger, Gary J. Hoffman, Julia Hess, Laura B. Kuhn, Tim Ammon, Johnny Kim, Günter Schneider, Kristian Unger, Ursula Zimber-Strobl, Mathias Heikenwälder, Marc Schmidt-Supprian, Fengtang Yang, Dieter Saur, Pentao Liu, Katja Steiger, Dmitriy M. Chudakov, Georg Lenz, Leticia Quintanilla-Martinez, Ulrich Keller, George S. Vassiliou, Juan Cadiñanos, Allan Bradley, Roland Rad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Identification of cancer genes altered by non-genetic mechanisms in B-cell lymphoma is challenging. Here, the authors report the development of transposon tools to perform genome-wide recessive screens in vivo and validate identified putative tumor s
Externí odkaz:
https://doaj.org/article/3cd9593b5a3c449085e3011eabf08516
Autor:
Jordan K. Boutilier, Rhonda L. Taylor, Tracy Mann, Elyshia McNamara, Gary J. Hoffman, Jacob Kenny, Rodney J. Dilley, Peter Henry, Grant Morahan, Nigel G. Laing, Kristen J. Nowak
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2999-3017 (2017)
The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the p
Externí odkaz:
https://doaj.org/article/eaa119af9d3f4af284829c217d65411c
Autor:
Cavan Bennett, Moyra Lawrence, Jose A. Guerrero, Simon Stritt, Amie K. Waller, Yahui Yan, Richard W. Mifsud, Jose Ballester-Beltrán, Ayesha Baig, Annett Mueller, Louisa Mayer, James Warland, Christopher J. Penkett, Parsa Akbari, Thomas Moreau, Amanda L. Evans, Souradip Mookerjee, Gary J. Hoffman, Kourosh Saeb-Parsy, David J. Adams, Amber L. Couzens, Markus Bender, Wendy N. Erber, Bernhard Nieswandt, Randy J. Read, Cedric Ghevaert
Publikováno v:
Blood. 139:2227-2239
The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e0ff77a46b889fca56887fe7308296
https://doi.org/10.1182/blood.2021013113
https://doi.org/10.1182/blood.2021013113
Autor:
Jacob Kenny, Grant Morahan, Gary J. Hoffman, Tracy S. Mann, J. Boutilier, Nigel G. Laing, Peter J. Henry, Kristen J. Nowak, Elyshia McNamara, Rodney J. Dilley, Rhonda L. Taylor
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2999-3017 (2017)
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 2999-3017 (2017)
The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4271626aa1e0ef90951dd1a0f0bdc161
Autor:
Sandra Bernaldo de Quirós, Qi Liang, Hannes Ponstingl, María Soledad Fernández-García, Alexander Strong, George S. Vassiliou, Jorge de la Rosa, Julia Weber, Carlos López-Otín, Rocio Fuente, Emmanouil Metzakopian, Mathias J Friedrich, Juan Cadiñanos, Gary J. Hoffman, Lena Rad, María Teresa Fernández-García, Imran Noorani, Meng Amy Li, Aurora Astudillo, Yang Li, Roland Rad, Allan Bradley
Publikováno v:
Nature genetics
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9732a3189b17ff32d95a3185e1e437c7
http://europepmc.org/articles/PMC5409503
http://europepmc.org/articles/PMC5409503
Autor:
Thomas Engleitner, Fengtang Yang, Kristian Unger, Robert Lersch, Gary J. Hoffman, Julia Hess, Mathias J Friedrich, Ruby Banerjee, Lena Rad, Michael Grau, Georg Lenz, Mathias Heikenwalder, Ursula Kohlhofer, Anna Katharina Scherger, Olga Baranov, Manuela Martella, Juan Cadiñanos, Jorge de la Rosa, Tim Ammon, Ulrich Keller, Rupert Öllinger, Leticia Quintanilla-Martinez, Günter Schneider, Carolyn S. Grove, Anja Pfaus, Allan Bradley, Irene Gonzalez Menendez, George S. Vassiliou, Marc Schmidt-Supprian, Alexander Strong, Maria A. Turchaninova, Julia Weber, Johnny Kim, Dmitriy M. Chudakov, Dieter Saur, Laura B. Kuhn, Ursula Zimber-Strobl, Pentao Liu, Roland Rad, Markus Schick, Katja Steiger
Publikováno v:
Nat. Commun. 10:1415 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer genes remains challenging. Here, we describe PiggyBac transposon tools and mouse models fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d2644306f9283cc916d9683eb98d43
https://mediatum.ub.tum.de/1544144
https://mediatum.ub.tum.de/1544144
Autor:
Elena A.B. Azizan, Gary J. Hoffman, Brian Y.H. Lam, Junhua Zhou, Alison Marker, Rhoda E. Kuc, Jennifer Clarke, Morris J. Brown, Lisa Happerfield, Stephen Newhouse
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E819-E829
Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of somatic KCNJ5 mutations suggests a genetic explanation.The objectives of this study were the following: 1) to compare transcriptional profiles in APA and adjacent adrenal g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f61b1987d6b4e5e52599d4e17d4b7b8
https://doi.org/10.1210/jc.2011-2965
https://doi.org/10.1210/jc.2011-2965
Autor:
María José Sánchez, Berthold Göttgens, Lev Silberstein, Sandie Piltz, Anthony R. Green, Merav Socolovsky, Mark Bowen, Gary J. Hoffman, Sarah Kinston, Laure Gambardella, Ying Liu
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
11 páginas, 5 figuras, 1 tabla.
Appropriate transcriptional regulation is critical for the biological functions of many key regulatory genes, including the stem cell leukemia (SCL) gene. As part of a systematic dissection of SCL transcriptional
Appropriate transcriptional regulation is critical for the biological functions of many key regulatory genes, including the stem cell leukemia (SCL) gene. As part of a systematic dissection of SCL transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fcf118a5395c4d1cc0371c99d579c8
https://doi.org/10.1634/stemcells.2005-0090
https://doi.org/10.1634/stemcells.2005-0090
Publikováno v:
Journal of Clinical Pathology. 50:389-393
AIMS: The detection of cellular antigens in fixed decalcified bone marrow trephine (BMT) sections depends on the method of processing, the nature of the antigen and antibody, antigen retrieval techniques, and the sensitivity of the immunocytochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f17784bb75b122b79085ee9b1e888a
https://doi.org/10.1136/jcp.50.5.389
https://doi.org/10.1136/jcp.50.5.389
Autor:
Hannes Ponstingl, Vincenzo Calvanese, Carolyn Grove, Günter Schneider, George S. Vassiliou, Roland Rad, Thomas Kirchner, Gary J. Hoffman, Mario F. Fraga, Maren Hieber, Alexander Strong, Pentao Liu, Dieter Saur, Allan Bradley, Ignacio Varela, Fernando Constantino-Casas, Juan Cadiñanos, Stefan Eser, Ultan McDermott, Barbara Seidler, Lena Rad, Wei Wang, Stacey Price, Lydia Kriegl, Kosuke Yusa, Roland M. Schmid
Publikováno v:
SCOPUS
Cancer Cell
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
Cancer Cell
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
Digital.CSIC. Repositorio Institucional del CSIC
Under a Creative Commons license.-- et al.
We show that BRAFV600E initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs
We show that BRAFV600E initiates an alternative pathway to colorectal cancer (CRC), which progresses through a hyperplasia/adenoma/carcinoma sequence. This pathway underlies significant subsets of CRCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55114cd40f13e8b5a7102335c27e152a
http://hdl.handle.net/10651/18463
http://hdl.handle.net/10651/18463