Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans.

Autor: Lidan Zeng, Xuesong Li, Christopher B Preusch, Gary J He, Ningyi Xu, Tom H Cheung, Jianan Qu, Ho Yi Mak

Publikováno v: PLoS Genetics, Vol 17, Iss 7, p e1009635 (2021)

The intracellular level of fatty aldehydes is tightly regulated by aldehyde dehydrogenases to minimize the formation of toxic lipid and protein adducts. Importantly, the dysregulation of aldehyde dehydrogenases has been implicated in neurologic disor

Externí odkaz: https://doaj.org/article/cbb613c97fc64fb7b0ee4a428749f2cb

Nuclear receptor NHR-49 promotes peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency inC. elegans

Autor: Christopher B. Preusch, Jianan Y. Qu, Ho Yi Mak, Xuesong Li, Ningyi Xu, Gary J. He, Tom H. Cheung, Lidan Zeng

The intracellular level of fatty aldehydes is tightly regulated to minimize the formation of toxic aldehyde adducts of cellular components. Accordingly, deficiency of a fatty aldehyde dehydrogenase FALDH causes the neurologic disorder Sjögren-Larsso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5571e7e397a7941f4d9e1092fcc6a96
https://doi.org/10.1101/2020.12.04.411637

High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations

Autor: Gary J. He, Aurélien Corneau, Tom H. Cheung, Elisa Negroni, Hiroshi Sakai, M. Mona Siu, Raymond Wan, Shahragim Tajbakhsh, Lorenzo Giordani, Justin Y. C. Law, Fabien Le Grand

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2019, 74 (3), pp.609-621.e6. ⟨10.1016/j.molcel.2019.02.026⟩
Molecular Cell, 2019, 74 (3), pp.609-621.e6. ⟨10.1016/j.molcel.2019.02.026⟩

International audience; Adult tissue repair and regeneration require stem-progenitor cells that can self-renew and generate differentiated progeny. Skeletal muscle regenerative capacity relies on muscle satellite cells (MuSCs) and their interplay wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b39aea4fb8ca4e7185adbe7f87a1f19
https://pubmed.ncbi.nlm.nih.gov/30922843

High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle Resident Cell Populations

Autor: Aurélien Corneau, Justin Y. C. Law, Lorenzo Giordani, M. Mona Siu, Hiroshi Sakai, Shahragim Tajbakhsh, Fabien Le Grand, Gary J. He, Tom H. Cheung, Raymond Wan, Elisa Negroni

Publikováno v: SSRN Electronic Journal.

Adult tissue repair and regeneration require the activation of resident stem and progenitor cells that can self-renew and generate differentiated progeny. The regenerative capacity of skeletal muscle relies on muscle satellite cells (MuSCs) and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61a0daa601b7b1e0b69d2198ca868163
https://doi.org/10.2139/ssrn.3249467