Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Gary J Schwartz"'
Autor:
Yan Tang, Haihong Zong, Hyokjoon Kwon, Yunping Qiu, Jacob B Pessin, Licheng Wu, Katherine A Buddo, Ilya Boykov, Cameron A Schmidt, Chien-Te Lin, P Darrell Neufer, Gary J Schwartz, Irwin J Kurland, Jeffrey E Pessin
Publikováno v:
eLife, Vol 11 (2022)
Cholinergic and sympathetic counter-regulatory networks control numerous physiological functions, including learning/memory/cognition, stress responsiveness, blood pressure, heart rate, and energy balance. As neurons primarily utilize glucose as thei
Externí odkaz:
https://doaj.org/article/e95994c3aa1f45b29619ac86493dbd58
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2004399 (2018)
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient
Externí odkaz:
https://doaj.org/article/0310a5c47dbd47f3aa807dd68e1954d5
Autor:
Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet
Publikováno v:
eLife, Vol 6 (2017)
Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the bra
Externí odkaz:
https://doaj.org/article/cfa6ba77c17c4c99b02a679f8fe69bff
Autor:
Raddy L. Ramos, Maider Michelena Beltran De Heredia, Yongwei Zhang, Randy F. Stout, Jaafar O. Tindi, Liching Wu, Gary J. Schwartz, Yair M. Botbol, Simone Sidoli, Ankita Poojari, Tammy Rakowski-Anderson, Bridget Shafit-Zagardo
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106594- (2024)
Aims: Cytoplasmic dynein heavy chain (DYNC1H1) is a multi-subunit protein complex that provides motor force for movement of cargo on microtubules and traffics them back to the soma. In humans, mutations along the DYNC1H1 gene result in intellectual d
Externí odkaz:
https://doaj.org/article/6c07a9ad44774ed0968d3018b7640dc1
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118888 (2015)
Hyperphagic obesity is characterized in part by a specific increase in meal size that contributes to increased daily energy intake, but the mechanisms underlying impaired activity of meal size regulatory circuits, particularly those converging at the
Externí odkaz:
https://doaj.org/article/db8d72e886bf48aa8db2df5be6c26d76
Autor:
Zhonghai Yan, Hanjie Zhang, Christina Maher, Emilio Arteaga-Solis, Frances A Champagne, Licheng Wu, Jacob D McDonald, Beizhan Yan, Gary J Schwartz, Rachel L Miller
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110706 (2014)
RationaleGreater levels of prenatal exposure to polycyclic aromatic hydrocarbon (PAH) have been associated with childhood obesity in epidemiological studies. However, the underlying mechanisms are unclear.ObjectivesWe hypothesized that prenatal PAH o
Externí odkaz:
https://doaj.org/article/13b70389bb944b83b6e551fccd338288
Autor:
Clémence Blouet, Gary J Schwartz
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51898 (2012)
Previous evidence indicates that duodenal lipid sensing engages gut-brain neurocircuits to determine food intake and hepatic glucose production, but a potential role for gut-brain communication in the control of energy expenditure remains to be deter
Externí odkaz:
https://doaj.org/article/861d6ded9e4042a2a043648da3bb04fd
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32511 (2012)
Serotonin reuptake transporter (SERT) is a key regulator of serotonin neurotransmission and a major target of antidepressants. Antidepressants, such as selectively serotonin reuptake inhibitors (SSRIs), that block SERT function are known to affect fo
Externí odkaz:
https://doaj.org/article/9c666f56bd0d44dbbc5cb7d631362ef7
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17058 (2011)
MKR mice, lacking insulin-like growth factor 1 receptor (IGF-1R) signaling in skeletal muscle, are lean yet hyperlipidemic, hyperinsulinemic, and hyperglycemic, with severe insulin resistance and elevated hepatic and skeletal muscle levels of triglyc
Externí odkaz:
https://doaj.org/article/f881f3f6efa64104bd93fd94aaf9ddf3
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15748 (2010)
Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS).
Externí odkaz:
https://doaj.org/article/5f2629f246524b4aa40da9fca47778d5