Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Gary J Patti"'
Autor:
Francisco Victorino, Tarin M Bigley, Eugene Park, Cong-Hui Yao, Jeanne Benoit, Li-Ping Yang, Sytse J Piersma, Elvin J Lauron, Rebecca M Davidson, Gary J Patti, Wayne M Yokoyama
Publikováno v:
eLife, Vol 10 (2021)
Natural killer (NK) cells are essential for early protection against virus infection and must metabolically adapt to the energy demands of activation. Here, we found upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a fea
Externí odkaz:
https://doaj.org/article/3e3a62a1b135404db887eff1f946aea3
Publikováno v:
eLife, Vol 8 (2019)
Proliferating cells often have increased glucose consumption and lactate excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effect. Despite an increase in glycolysis, however, here we show that non-transfor
Externí odkaz:
https://doaj.org/article/e65f61cec7b345d382006736cb79f515
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2003782 (2018)
It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of
Externí odkaz:
https://doaj.org/article/01d1593120b64812bd6cc0cd1e6f7876
Autor:
Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H. Palacios, Maurie Balch, Macy L. Sprunger, Matthew K. Howard, Jeremy J. Ryan, Jessica N. Haines, Gary J. Patti, Albert A. Davis, Meredith E. Jackrel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Parkinson’s disease (PD) is closely linked to α-synuclein (α-syn) misfolding and accumulation in Lewy bodies. The PDZ serine protease HTRA1 degrades fibrillar tau, which is associated with Alzheimer’s disease, and inactivating mutation
Externí odkaz:
https://doaj.org/article/d3a814cfc6b44384be88ec4319bf5430
Autor:
Dipak D. Pukale, Kayla Adkins-Travis, Siddhartha R. Aryal, Leah P. Shriver, Gary J. Patti, Nic D. Leipzig
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-14 (2024)
Abstract Background Syringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post-spinal cord injury (SCI) is not well understood and only in
Externí odkaz:
https://doaj.org/article/11b7a6ea6683401da1bdea4442184b8a
Autor:
Gregory A. Harrison, Erin R. Wang, Kevin Cho, Yassin Mreyoud, Souvik Sarkar, Fredrik Almqvist, Gary J. Patti, Christina L. Stallings
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activit
Externí odkaz:
https://doaj.org/article/6376d9c665324f819f24fe9e4bf3fa83
Autor:
Nidhi Rohatgi, Wei Zou, Yongjia Li, Kevin Cho, Patrick L. Collins, Eric Tycksen, Gaurav Pandey, Carl J. DeSelm, Gary J. Patti, Anwesha Dey, Steven L. Teitelbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functi
Externí odkaz:
https://doaj.org/article/cccf1d8177fb4ec0a2c526ee79cec6f1
Autor:
Michaela Schwaiger-Haber, Ethan Stancliffe, Dhanalakshmi S. Anbukumar, Blake Sells, Jia Yi, Kevin Cho, Kayla Adkins-Travis, Milan G. Chheda, Leah P. Shriver, Gary J. Patti
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tumors are comprised of a multitude of cell types spanning different microenvironments. Mass spectrometry imaging (MSI) has the potential to identify metabolic patterns within the tumor ecosystem and surrounding tissues, but conventional wor
Externí odkaz:
https://doaj.org/article/c55e39b27a114caeaa92852ca2b1822e
Autor:
Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108196- (2023)
Summary: The liver coordinates the systemic response to nutrient deprivation and availability by producing glucose from gluconeogenesis during fasting and synthesizing lipids via de novo lipogenesis (DNL) when carbohydrates are abundant. Mitochondria
Externí odkaz:
https://doaj.org/article/802c3f379cbe48bdb9a10949ed2a6500
Autor:
Daniel Ferguson, Sophie J. Eichler, Nicole K.H. Yiew, Jerry R. Colca, Kevin Cho, Gary J. Patti, Trevor M. Shew, Andrew J. Lutkewitte, Sandip Mukherjee, Kyle S. McCommis, Natalie M. Niemi, Brian N. Finck
Publikováno v:
Molecular Metabolism, Vol 70, Iss , Pp 101694- (2023)
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We evaluated whether MPC inhibitors (MPCi) might correct impairments in
Externí odkaz:
https://doaj.org/article/3898d186981f4a0e95dd6457eab4e374