Zobrazeno 1 - 10 of 58 pro vyhledávání: '"Gary J Litherland"'
1
Akademický článek
Protein kinase D3 modulates MMP1 and MMP13 expression in human chondrocytes.
Autor: Jonathan Baker, Adrian M D Falconer, David J Wilkinson, G Nicholas Europe-Finner, Gary J Litherland, Andrew D Rowan
Publikováno v: PLoS ONE, Vol 13, Iss 4, p e0195864 (2018)
Many catabolic stimuli, including interleukin-1 (IL-1) in combination with oncostatin M (OSM), promote cartilage breakdown via the induction of collagen-degrading collagenases such as matrix metalloproteinase 1 (MMP1) and MMP13 in human articular cho
Externí odkaz: https://doaj.org/article/dd7b44edb653406f81df8918086f1e74
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2
Akademický článek
Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1) selectively contributes to MMP1 expression in human chondrocytes.
Autor: Christopher D Macdonald, Adrian M D Falconer, Chun Ming Chan, David J Wilkinson, Andrew Skelton, Louise Reynard, Gary J Litherland, G Nicholas Europe-Finner, Andrew D Rowan
Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0207240 (2018)
Irreversible cartilage collagen breakdown by the collagenolytic matrix metalloproteinases (MMPs)-1 and MMP-13 represents a key event in pathologies associated with tissue destruction such as arthritis. Inflammation is closely associated with such pat
Externí odkaz: https://doaj.org/article/6794cdb9cbfc432f992af1601bd2260d
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3
Akademický článek
Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis
Autor: Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells
Externí odkaz: https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f
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4
Moderate Exercise Protects Against Joint Disease in a Murine Model of Osteoarthritis
Autor: Rob van 't Hof, Kendall McCulloch, Kayleigh MacDougal, Carl S. Goodyear, William R. Ferrell, Sarah McGrath, Lynette Dunning, John C. Lockhart, Ana C. Ortiz, Margaret Fegen, Carmen Huesa, Anne Crilly, Gary J. Litherland
Exercise is recommended as a non-pharmacological therapy for osteoarthritis (OA). Clinical studies investigating the impact of exercise on OA have primarily focussed on the assessment of joint pain and mobilisation, where positive outcomes have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e95591aacebde0d7cc039d36fc4ddad8
https://doi.org/10.21203/rs.3.rs-1054109/v1
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5
Investigating the Transcriptome of Candida albicans in a Dual-Species Staphylococcus aureus Biofilm Model
Autor: Bryn Short, Christopher Delaney, Emily McKloud, Jason L. Brown, Ryan Kean, Gary J. Litherland, Craig Williams, S. Lorraine Martin, William G. MacKay, Gordon Ramage
Publikováno v: Short, B, Delaney, C, McKloud, E, Brown, J, Kean, R, Litherland, G J, Williams, C, Martin, S L, MacKay, W G & Ramage, G 2021, ' Investigating the Transcriptome of Candida albicans in a Dual-Species Staphylococcus aureus Biofilm Model ', Frontiers in Cellular and Infection Microbiology, vol. 11, 791523 . https://doi.org/10.3389/fcimb.2021.791523
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Candida albicans is an opportunistic pathogen found throughout multiple body sites and is frequently co-isolated from infections of the respiratory tract and oral cavity with Staphylococcus aureus. Herein we present the first report of the effects th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989678db1621e84a26049ad27f6c65e7
https://doi.org/10.3389/fcimb.2021.791523
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8
Therapeutic Targets for the Treatment of Chronic Cough
Autor: Gary J. Litherland, Fionnuala Lundy, Nicola Roe, Lorcan McGarvey
Publikováno v: Roe, N A, Lundy, F T, Litherland, G J & McGarvey, L P A 2019, ' Therapeutic targets for the treatment of chronic cough ', Current Otorhinolaryngology Reports, vol. 7, pp. 116-128 . https://doi.org/10.1007/s40136-019-00239-9
Purpose of ReviewChronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a promin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a409d9013aed558bd9b4ec26caf90fa4
https://doi.org/10.1007/s40136-019-00239-9
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9
Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases
Autor: Mark A. Hollywood, Mariarca Bailo, Lorcan McGarvey, Gary J. Litherland, S. Lorraine Martin, John C. Lockhart, Fionnuala Lundy, James Reihill, Emma L. Carroll, Anne Crilly
Publikováno v: Carroll, E L, Bailo, M, Reihill, J A, Crilly, A, Lockhart, J C, Litherland, G J, Lundy, F T, McGarvey, L P, Hollywood, M A & Martin, S L 2021, ' Trypsin-Like Proteases and Their Role in Muco-Obstructive Lung Diseases ', International Journal of Molecular Sciences, vol. 22, no. 11, e5817 . https://doi.org/10.3390/ijms22115817
International Journal of Molecular Sciences, Vol 22, Iss 5817, p 5817 (2021)
International Journal of Molecular Sciences
Trypsin-like proteases (TLPs) belong to a family of serine enzymes with primary substrate specificities for the basic residues, lysine and arginine, in the P1 position. Whilst initially perceived as soluble enzymes that are extracellularly secreted,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1cbf142a2855316f75b49dce665dca
https://pure.qub.ac.uk/en/publications/trypsinlike-proteases-and-their-role-in-mucoobstructive-lung-diseases(d72d27a7-4665-4271-a499-9b6281ff85b4).html
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10
S50 Oxidative stress driven inflammatory responses in lung epithelial cells
Autor: Gary J. Litherland, Carl S. Goodyear, Joanna Brzeszczynska, Lorcan McGarvey, F Tarhini, Keith D. Thornbury, John C. Lockhart, Anne Crilly
Publikováno v: Respiratory science: state of the art.
Cigarette smoke stimulates an inflammatory response and produces oxidants that cause oxidative stress in the lung, promoting pathophysiological changes related to chronic obstructive pulmonary disease (COPD).1 Hydrogen peroxide (H2O2) is an important
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4b537c6551258bc23791c7d1ede97f9
https://doi.org/10.1136/thorax-2020-btsabstracts.55
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