Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Gary J, Schwartz"'
Autor:
Raddy L. Ramos, Maider Michelena Beltran De Heredia, Yongwei Zhang, Randy F. Stout, Jaafar O. Tindi, Liching Wu, Gary J. Schwartz, Yair M. Botbol, Simone Sidoli, Ankita Poojari, Tammy Rakowski-Anderson, Bridget Shafit-Zagardo
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106594- (2024)
Aims: Cytoplasmic dynein heavy chain (DYNC1H1) is a multi-subunit protein complex that provides motor force for movement of cargo on microtubules and traffics them back to the soma. In humans, mutations along the DYNC1H1 gene result in intellectual d
Externí odkaz:
https://doaj.org/article/6c07a9ad44774ed0968d3018b7640dc1
Autor:
Eunjin Kwon, Hye-Young Joung, Shun-Mei Liu, Streamson C. Chua, Gary J. Schwartz, Young-Hwan Jo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Hypothalamic melanocortin neurons regulate systemic glucose homeostasis through incompletely understood pathways. Here, the authors show that a subset of pro-opiomelanocortin neurons innervate the liver via preganglionic parasympathetic cholinergic n
Externí odkaz:
https://doaj.org/article/fe3b417b3e654fd0a95ad82351d23a97
Autor:
Yan Tang, Haihong Zong, Hyokjoon Kwon, Yunping Qiu, Jacob B Pessin, Licheng Wu, Katherine A Buddo, Ilya Boykov, Cameron A Schmidt, Chien-Te Lin, P Darrell Neufer, Gary J Schwartz, Irwin J Kurland, Jeffrey E Pessin
Publikováno v:
eLife, Vol 11 (2022)
Cholinergic and sympathetic counter-regulatory networks control numerous physiological functions, including learning/memory/cognition, stress responsiveness, blood pressure, heart rate, and energy balance. As neurons primarily utilize glucose as thei
Externí odkaz:
https://doaj.org/article/e95994c3aa1f45b29619ac86493dbd58
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 12, Pp 2349-2359 (2018)
Dietary fat absorption takes place in the intestine, and the liver mobilizes endogenous fat to other tissues by synthesizing lipoproteins that require apoB and microsomal triglyceride transfer protein (MTP). Dietary fat triggers the synthesis of oleo
Externí odkaz:
https://doaj.org/article/bf167ffa54e9445c9193b19ae5fc11f8
Autor:
Shunmei Liu, Genevieve Marcelin, Clemence Blouet, Jae Hoon Jeong, Young-Hwan Jo, Gary J. Schwartz, Streamson Chua, Jr.
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 37-50 (2018)
Objective: Bile acids have been implicated as important regulators of glucose metabolism via activation of FXR and GPBAR1. We have previously shown that FGF19 can modulate glucose handling by suppressing the activity of hypothalamic AGRP/NPY neurons.
Externí odkaz:
https://doaj.org/article/dfa97d425c01435aa865982a75668b1b
Autor:
John T. Garretson, Laura A. Szymanski, Gary J. Schwartz, Bingzhong Xue, Vitaly Ryu, Timothy J. Bartness
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 626-634 (2016)
Objective: Metabolic challenges, such as a cold environment, stimulate sympathetic neural efferent activity to white adipose tissue (WAT) to drive lipolysis, thereby increasing the availability of free fatty acids as one source of fuel for brown adip
Externí odkaz:
https://doaj.org/article/ffb5eead0023466f9a8175609c2b3bbe
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2004399 (2018)
Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARC) respond to numerous hormonal and neural signals, resulting in changes in food intake. Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient
Externí odkaz:
https://doaj.org/article/0310a5c47dbd47f3aa807dd68e1954d5
Autor:
Huidong Shi, Gary J. Schwartz, Fenfen Li, Bingzhong Xue, Shirong Wang, Rui Wu, Liqing Yu, Jia Jing, Xin Cui, Qiang Cao, Ke Li, Hang Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Activation of brown fat thermogenesis increases energy expenditure and alleviates obesity. Sympathetic nervous system (SNS) is important in brown/beige adipocyte thermogenesis. Here we discover a fat-derived “adipokine” neurotrophic factor neurot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b537a43411fc9cda4d4ddab940ce90
https://doaj.org/article/74f4186b66d4405aa52f8f0ea75e6eb1
https://doaj.org/article/74f4186b66d4405aa52f8f0ea75e6eb1
Autor:
Jae Hoon Jeong, Dong Kun Lee, Clemence Blouet, Henry H. Ruiz, Christoph Buettner, Streamson Chua, Jr., Gary J. Schwartz, Young-Hwan Jo
Publikováno v:
Molecular Metabolism, Vol 4, Iss 6, Pp 483-492 (2015)
Objective: Brown adipose tissue (BAT) thermogenesis is critical in maintaining body temperature. The dorsomedial hypothalamus (DMH) integrates cutaneous thermosensory signals and regulates adaptive thermogenesis. Here, we study the function and synap
Externí odkaz:
https://doaj.org/article/17d1ab3d576446ffb2680a5dec743953
Autor:
Gary J. Schwartz, Rogerio O. Batista, Natalie R. Lopatinsky, Marko Kraljević, Caroline S. Jiang, Amanda S. Dirnberger, Ana B. Emiliano
Although sleeve gastrectomy (SG) is the most commonly performed bariatric surgery in the US, its mechanistic underpinnings have not been fully determined. Thus, we set out to investigate whether SG’s effects on the peripheral sympathetic system cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::943a5465fe73c8fdc136a49fbb2c7dbc
https://doi.org/10.1101/2022.10.17.512615
https://doi.org/10.1101/2022.10.17.512615
