Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Gary J, Doherty"'
Autor:
Gerald J. Sun, Gustavo Arango-Argoty, Gary J. Doherty, Damian E. Bikiel, Dejan Pavlovic, Allen C. Chen, Ross A. Stewart, Zhongwu Lai, Etai Jacob
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110634- (2024)
Summary: System-level patient health signals, as captured by treatment-emergent adverse events (TEAEs), might contain correlates of immune checkpoint inhibitor (ICI) therapy response. Using all TEAEs and a novel machine learning modeling approach, we
Externí odkaz:
https://doaj.org/article/6446394258df4e7ba96e718b2a6519bd
Autor:
Nicola A. Thompson, Grant D. Stewart, Sarah J. Welsh, Gary J. Doherty, Matthew J. Robinson, B. Anne Neville, Kevin Vervier, Simon R. Harris, David J. Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D. Lawley, Pippa G. Corrie
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background The gut microbiome is implicated as a marker of response to immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early studies suggest faecal mic
Externí odkaz:
https://doaj.org/article/715ab5e8f0424381af262366a64b1240
Autor:
Hui‐Ling Ou, Reuben Hoffmann, Cristina González‐López, Gary J. Doherty, James E. Korkola, Daniel Muñoz‐Espín
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2634-2671 (2021)
Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in response to stress. This response also involves other distinct morphological and intracellular changes including alterations in gene expression and epigenetic m
Externí odkaz:
https://doaj.org/article/f762a6bb0f37468c999497ca19af1f9b
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-19 (2019)
Abstract Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is consid
Externí odkaz:
https://doaj.org/article/f1552ee743934e8493ca70abe9e11fb1
Autor:
Neal, Navani, Rachel, Butler, Salma, Ibrahimo, Anjali, Verma, Matthew, Evans, Gary J, Doherty, Samreen, Ahmed
Publikováno v:
Lung Cancer. 172:142-153
Targeted therapy against actionable variants has revolutionised the treatment landscape for non-small cell lung cancer (NSCLC). Approximately half of NSCLC adenocarcinomas have an actionable variant, making molecular testing a critical component of t
Autor:
Brady Bernard, Shawn M. Sweeney, Thomas V. Yu, Nikolaus Schultz, Stephen-John Sammut, Andrea Ovalle, Tali Mazor, James Lindsay, Marilyn M. Li, Michele L. Lenoue-Newton, Priti Kumari, Haley Hunter-Zinck, Michelle F. Green, Matthew Galvin, Gary J. Doherty, Jeff P. Bruce, Jonathan L. Bell, Trevor J. Pugh
The American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) is an international pan-cancer registry with the goal to inform cancer research and clinical care worldwide. Founded in late 2015, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383af890dfc7179ff3a8ce8f4912b8d5
https://doi.org/10.1158/2159-8290.c.6549518.v1
https://doi.org/10.1158/2159-8290.c.6549518.v1
Autor:
Brady Bernard, Shawn M. Sweeney, Thomas V. Yu, Nikolaus Schultz, Stephen-John Sammut, Andrea Ovalle, Tali Mazor, James Lindsay, Marilyn M. Li, Michele L. Lenoue-Newton, Priti Kumari, Haley Hunter-Zinck, Michelle F. Green, Matthew Galvin, Gary J. Doherty, Jeff P. Bruce, Jonathan L. Bell, Trevor J. Pugh
Supplementary Table from AACR Project GENIE: 100,000 Cases and Beyond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c493b80c6a8dd32c9e29bfea3efcadf
https://doi.org/10.1158/2159-8290.22540943
https://doi.org/10.1158/2159-8290.22540943
Autor:
Brady Bernard, Shawn M. Sweeney, Thomas V. Yu, Nikolaus Schultz, Stephen-John Sammut, Andrea Ovalle, Tali Mazor, James Lindsay, Marilyn M. Li, Michele L. Lenoue-Newton, Priti Kumari, Haley Hunter-Zinck, Michelle F. Green, Matthew Galvin, Gary J. Doherty, Jeff P. Bruce, Jonathan L. Bell, Trevor J. Pugh
Supplementary Figure from AACR Project GENIE: 100,000 Cases and Beyond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd892c0f836423e7fa81c5d92a65e0
https://doi.org/10.1158/2159-8290.22540961
https://doi.org/10.1158/2159-8290.22540961
Autor:
Estela González-Gualda, David Macias, Samir Morsli, José Ezequiel Martín, Hui-Ling Ou, Mary Denholm, Ioana Olan, Reuben Hoffmann, Mark Dane, Dimitris Veroutis, Guillermo Medrano, Francisca Mulero, Carla P. Martins, Mariano Barbacid, Vassilis Gorgoulis, James E. Korkola, Doris M. Rassl, Gary J. Doherty, Robert C. Rintoul, Masashi Narita, Daniel Muñoz-Espín
Platinum-based chemotherapy is commonly used for non-small cell lung cancer (NSCLC) treatment, yet clinical outcomes remain poor. Cellular senescence and its associated secretory phenotype (SASP) can have multiple tumour-promoting activities, althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b2bb945606577f05bb5051e573af309
https://doi.org/10.1101/2022.08.01.502019
https://doi.org/10.1101/2022.08.01.502019
Autor:
Allanah Barker, David Gilligan, Bruno Henrique Rala De Paula, Anna L. Paterson, Gary J. Doherty, Mike Hubank, Rosalind Kieran
Publikováno v:
JCO precision oncology. 5