Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Gary H. Rasmusson"'
1
Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Autor: Georgianna Harris, Walter F. Baginsky, Raman K. Bakshi, Margarita Garcia-Calvo, Stefan Andersson, Dina E. Ellsworth, Herbert G. Bull, Randall R. Miller, Robert W. Myers, and John W. Kozarich, H. Karen Chan, Ralph A. Stearns, Richard L. Tolman, Gary H. Rasmusson
Publikováno v: Journal of the American Chemical Society. 118:2359-2365
Finasteride is employed in treatment of benign prostatic hyperplasia in man, where its target enzyme is steroid 5α-reductase. It is a novel, potent mechanism-based inhibitor of the human prostate (type 2) isozyme. Although it is accepted as an alter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bde807c60903f472d5553a04bcb3d7f9
https://doi.org/10.1021/ja953069t
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2
Comparison of the effects of new specific azasteroid inhibitors of steroid 5α-reductase on canine hyperplastic prostate: Suppression of prostatic DHT correlated with prostate regression
Autor: Sheila M. Cohen, G Harris, J G Jacobs, W K Tanaka, Gary H. Rasmusson, T M Nett, Jeffrey G. Werrmann, P. F. Malatesta, Srinivasa Prahalada
Publikováno v: The Prostate. 26:55-71
Four new azasteroid inhibitors of steroid 5 alpha-reductase were compared to the benchmark compound finasteride, each at a dose level of 1 mg/kg/day, as well to placebo and to castration, in seven groups of mature male beagle dogs with enlarged prost
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe170e9ccd86ec874e441fdeaa76c7ec
https://doi.org/10.1002/pros.2990260202
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5
A stereoselective synthesis of 7β-phenyl and 7β-methylcholesterol
Autor: Raman K. Bakshi, Gary H. Rasmusson
Publikováno v: Tetrahedron Letters. 34:2055-2058
A stereoselective synthesis of 7β-phenylcholesterol and 7β-methylcholesterol is described.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a207bf772a5cefe24a866e372f7563d
https://doi.org/10.1016/s0040-4039(00)60344-1
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7
Substituted penta- and hexapeptides as potent inhibitors of herpes simplex virus type 2 ribonucleotide reductase
Autor: John Hannah, W.L. McClements, Wallace T. Ashton, G. Yamanaka, Gary H. Rasmusson, C. Uncapher, Victor M. Garsky, R. L. Tolman, Gool F. Patel, T.J. Ikeler, Linda L. Chang
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:1207-1212
Structural modifications of the Tyr, Asn, and Leu residues of YVVNDL, a peptide which is equipotent to YAGAVVNDL in the inhibition of herpes simplex virus type 2 ribonucleotide reductase (HSV-2 RR), have produced peptides which are as much as 90- to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7bdba9c1acbece119eb659853c4ba41
https://doi.org/10.1016/s0960-894x(00)80215-2
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8
Topical anti-androgenicity of a new 4-azasteroid in the hamster
Autor: R. L. Primka, Charles Bel-man, D Krupa, Gary H. Rasmusson, J. R. Brooks, Glenn F. Reynolds
Publikováno v: Steroids. 56:428-433
The topical anti-androgenic activity of L-651,580 (methyl 3-oxo-4-methyl-4-aza-5 alpha-androst-1-ene-17 beta-carboxylate) was established in a series of for experiments using castrated male hamsters. During each 21-day experiment, the animals receive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846cef36e91751b059ebe8cb292937f2
https://doi.org/10.1016/0039-128x(91)90031-p
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