Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Gary H. Cohen"'
Autor:
Kathleen Boesze-Battaglia, Gary H. Cohen, Paul F. Bates, Lisa M. Walker, Ali Zekavat, Bruce J. Shenker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and Cdt
Externí odkaz:
https://doaj.org/article/b4dc70dc12ab4fc7a84cf22c58d7d983
Autor:
Kevin P. Egan, Sita Awasthi, Giulia Tebaldi, Lauren M. Hook, Alexis M. Naughton, Bernard T. Fowler, Mitchell Beattie, Mohamad-Gabriel Alameh, Drew Weissman, Gary H. Cohen, Harvey M. Friedman
Publikováno v:
Viruses, Vol 15, Iss 7, p 1483 (2023)
HSV-1 disease is a significant public health burden causing orofacial, genital, cornea, and brain infection. We previously reported that a trivalent HSV-2 gC2, gD2, gE2 nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccine provides excellent prot
Externí odkaz:
https://doaj.org/article/4ef81b6da24b4b0e90b0bd78a21e8ba3
Autor:
Sita Awasthi, Motoyasu Onishi, John M. Lubinski, Bernard T. Fowler, Alexis M. Naughton, Lauren M. Hook, Kevin P. Egan, Masaki Hagiwara, Seiki Shirai, Akiho Sakai, Takayuki Nakagawa, Kumiko Goto, Osamu Yoshida, Alisa J. Stephens, Grace Choi, Gary H. Cohen, Kazufumi Katayama, Harvey M. Friedman
Publikováno v:
Viruses, Vol 15, Iss 5, p 1148 (2023)
Herpes simplex virus type 2 (HSV-2) is a leading cause of genital ulcer disease and a major risk factor for acquisition and transmission of HIV. Frequent recurrent genital lesions and concerns about transmitting infection to intimate partners affect
Externí odkaz:
https://doaj.org/article/85b38cdef9e547f7a97265fe8e4bc36b
Autor:
Doina Atanasiu, Wan Ting Saw, Tina M. Cairns, Harvey M. Friedman, Roselyn J. Eisenberg, Gary H. Cohen
Publikováno v:
Viruses, Vol 15, Iss 4, p 895 (2023)
Herpes simplex virus (HSV) requires four essential virion glycoproteins—gD, gH, gL, and gB—for virus entry and cell fusion. To initiate fusion, the receptor binding protein gD interacts with one of two major cell receptors, HVEM or nectin-1. Once
Externí odkaz:
https://doaj.org/article/139f9394e3f1442584ed5210e04d903e
Autor:
Ceren Tuzmen, Tina M. Cairns, Doina Atanasiu, Huan Lou, Wan Ting Saw, Bonnie L. Hall, Justus B. Cohen, Gary H. Cohen, Joseph C. Glorioso
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 145-154 (2020)
Effective oncolytic virotherapy may require systemic delivery, tumor targeting, and resistance to virus-neutralizing (VN) antibodies. Since herpes simplex virus (HSV) glycoprotein D (gD) is the viral attachment/entry protein and predominant VN target
Externí odkaz:
https://doaj.org/article/f49b0000857a4c8d89afe3c3e52ac516
Autor:
Lauren M. Hook, Sita Awasthi, Tina M. Cairns, Mohamad-Gabriel Alameh, Bernard T. Fowler, Kevin P. Egan, Molly M. H. Sung, Drew Weissman, Gary H. Cohen, Harvey M. Friedman
Publikováno v:
Viruses, Vol 14, Iss 3, p 540 (2022)
The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the m
Externí odkaz:
https://doaj.org/article/76b703be13f248fdb48237fd38d0e99f
Autor:
Benjamin D. Brooks, Adam Closmore, Juechen Yang, Michael Holland, Tina Cairns, Gary H. Cohen, Chris Bailey-Kellogg
Publikováno v:
Molecules, Vol 25, Iss 16, p 3659 (2020)
Vaccines and immunotherapies depend on the ability of antibodies to sensitively and specifically recognize particular antigens and specific epitopes on those antigens. As such, detailed characterization of antibody–antigen binding provides importan
Externí odkaz:
https://doaj.org/article/eca87d14814249708975b9b6ad7abe14
Autor:
Juan Fontana, Doina Atanasiu, Wan Ting Saw, John R. Gallagher, Reagan G. Cox, J. Charles Whitbeck, Lauren M. Brown, Roselyn J. Eisenberg, Gary H. Cohen
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT All enveloped viruses, including herpesviruses, must fuse their envelope with the host membrane to deliver their genomes into target cells, making this essential step subject to interference by antibodies and drugs. Viral fusion is mediated
Externí odkaz:
https://doaj.org/article/bedf0d56e13a4379a5a712758525c86a
Autor:
Gary H. Cohen, Claude Krummenacher, Roselyn J. Eisenberg, John R. Gallagher, Tina M. Cairns, Doina Atanasiu
Publikováno v:
Viruses, Vol 4, Iss 5, Pp 800-832 (2012)
Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/g
Externí odkaz:
https://doaj.org/article/92769a0c1daf457096836f06d8cece41
Autor:
Doina Atanasiu, Tina M. Cairns, J. Charles Whitbeck, Wan Ting Saw, Samhita Rao, Roselyn J. Eisenberg, Gary H. Cohen
Publikováno v:
mBio, Vol 4, Iss 2 (2013)
ABSTRACT Herpesvirus entry requires the viral glycoprotein triad of gB and gH/gL to carry out fusion between the virion envelope and a cellular membrane in order to release the nucleocapsid into the target cell. Herpes simplex virus (HSV) also requir
Externí odkaz:
https://doaj.org/article/11718a2a284845c5b08b78366a1df839