Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Gary H. Perdew"'
Autor:
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters
Externí odkaz:
https://doaj.org/article/a855de1025a445adaa26ec6581764497
Autor:
Mallappa Anitha, Supriya M. Kumar, Imhoi Koo, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8581 (2024)
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent organic pollutant and a potent aryl hydrocarbon receptor (AHR) ligand, causes delayed intestinal motility and affects the survival of enteric neurons. In this study, we investigated the specifi
Externí odkaz:
https://doaj.org/article/ea0176d9aa964ee899571c14517e2426
Autor:
Bokai Zhu, Xiaoyang Zhu, Michael G. Borland, Douglas H. Ralph, Christopher R. Chiaro, Kristopher W. Krausz, James M. Ntambi, Adam B. Glick, Andrew D. Patterson, Gary H. Perdew, Frank J. Gonzalez, Jeffrey M. Peters
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 606 (2024)
Nuclear hormone receptors exist in dynamic equilibrium between transcriptionally active and inactive complexes dependent on interactions with ligands, proteins, and chromatin. The present studies examined the hypothesis that endogenous ligands activa
Externí odkaz:
https://doaj.org/article/231cd6ff406947e89aa731b290f06494
Autor:
Jeffry C. Granados, Kian Falah, Imhoi Koo, Ethan W. Morgan, Gary H. Perdew, Andrew D. Patterson, Neema Jamshidi, Sanjay K. Nigam
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification, development, immune response, chronic kidney disease and other syndromes. It regulates the expression of drug transporters and drug metabolizing enzy
Externí odkaz:
https://doaj.org/article/5bca312afba045ba961d8d346b2ebbad
Publikováno v:
Journal of Functional Foods, Vol 106, Iss , Pp 105602- (2023)
Diet-derived aryl hydrocarbon receptor (AHR) ligands have potential to maintain gut health. However, among the myriad bioactive compounds from foods, identifying novel functional ligands which would significantly impact gastrointestinal health is a c
Externí odkaz:
https://doaj.org/article/90dd1bc13b8042a9b4bc5025484d8ed8
Autor:
Dhwani Patel, Iain A. Murray, Fangcong Dong, Andrew J. Annalora, Krishne Gowda, Denise M. Coslo, Jacek Krzeminski, Imhoi Koo, Fuhua Hao, Shantu G. Amin, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew
Publikováno v:
Metabolites, Vol 13, Iss 9, p 985 (2023)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays an important role in gastrointestinal barrier function, tumorigenesis, and is an emerging drug target. The resident microbiota is capable of metabolizing trypto
Externí odkaz:
https://doaj.org/article/eb93d6bc3a4946b3bf3803357f3aeec6
Autor:
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernández-Salguero, Xavier Coumoul, Andrew D. Patterson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5550 (2023)
The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the l
Externí odkaz:
https://doaj.org/article/51868d43c72e45e9b088150fefa88fb8
Autor:
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-19 (2020)
Abstract The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity. Based on prior work that esta
Externí odkaz:
https://doaj.org/article/3bc1d75f8f9149f2b831e9fe3ca8d3bb
Autor:
Yuan Tian, Bipin Rimal, Wei Gui, Imhoi Koo, Shigetoshi Yokoyama, Gary H. Perdew, Andrew D. Patterson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8220 (2022)
Early life exposure to environmental pollutants may have long-term consequences and harmful impacts on health later in life. Here, we investigated the short- and long-term impact of early life 3,3′,4,4′,5-pentacholorobiphenyl (PCB 126) exposure (
Externí odkaz:
https://doaj.org/article/4d151452e68e4649bb4db74e34b4f2aa
Autor:
Anitha Vijay, Nina R Boyle, Supriya M Kumar, Gary H Perdew, Shanthi Srinivasan, Andrew D Patterson
Publikováno v:
Toxicological Sciences. 192:117-128
Despite progress describing the effects of persistent organic pollutants (POPs) on the central nervous system, the effect of POPs on enteric nervous system (ENS) function remains underexplored. We studied the effects of 2,3,7,8-tetrachlorodibenzo-p-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3d68fcfaf7f027de16f712d4fe2c561
https://doi.org/10.1093/toxsci/kfad014
https://doi.org/10.1093/toxsci/kfad014