Zobrazeno 1 - 10
of 441
pro vyhledávání: '"Gary H Posner"'
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24334 (2011)
We recently reported that two artemisinin-derived dimers (dimer primary alcohol 606 and dimer sulfone 4-carbamate 832-4) are significantly more potent in inhibiting human cytomegalovirus (CMV) replication than artemisinin-derived monomers. In our con
Externí odkaz:
https://doaj.org/article/20e2e507e63d41ec82ac86a0ea62ffd4
Autor:
Hyun Lee, Ravit Arav-Boger, Arun Kapoor, Fei Zhu, Ayan Kumar Ghosh, Rupkatha Mukhopadhyay, Sujayita Roy, Gary H. Posner, Jennifer R. Mazzone
Publikováno v:
J Biol Chem
The antimalarial agents artemisinins inhibit cytomegalovirus (CMV) in vitro and in vivo, but their target(s) has been elusive. Using a biotin-labeled artemisinin, we identified the intermediate filament protein vimentin as an artemisinin target, vali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e878df768872e2fc375b6165710fe312
https://doi.org/10.1074/jbc.ra120.014116
https://doi.org/10.1074/jbc.ra120.014116
Autor:
Theresa A. Shapiro, Gary H. Posner, Nirbhay Kumar, Bryan T. Mott, Vandana Singhal, Lauren E. Woodard
Publikováno v:
Pharmaceuticals, Vol 2, Iss 3, Pp 228-235 (2009)
Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariai
Externí odkaz:
https://doaj.org/article/73d88e2847ad49beab26f7b93ff74b1b
Publikováno v:
Tetrahedron. 72:6025-6030
In this report, several new epoxide examples were united with β-silyl ketone enolates for the construction, after oxidative fragmentation, of ring expanded lactones, n+3 atoms in size. Importantly, azido lactones were found to be valuable in an exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1cff0f181edf2de0c6e1d957c1a5f6f
https://doi.org/10.1016/j.tet.2016.05.063
https://doi.org/10.1016/j.tet.2016.05.063
Autor:
Douglas T. Genna, Gary H. Posner
Publikováno v:
Tetrahedron. 72:5968-5971
The clean synthesis of unsymmetrical ketones from carboxylic acid derivatives has been a challenge in the organic community dating back over 80 years. Herein we report the conversion of simple alkyl cinnamates to β,β-disubstituted ketones with cyan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55e8a181f72ca3193adcfe762122f3d2
https://doi.org/10.1016/j.tet.2016.05.003
https://doi.org/10.1016/j.tet.2016.05.003
Publikováno v:
Tetrahedron Letters. 57:3344-3348
Strongly electrophilic N-arenesulfonyl-2-pyridone-3-carboxylate methyl esters complex with zinc dibromide and then react with nucleophilic benzyl vinyl ether or benzyloxyallene to achieve inverse-electron-demand Diels–Alder (IEDDA) cycloadditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8cf075dad8576bd9e0f53dc84830116
https://doi.org/10.1016/j.tetlet.2016.06.068
https://doi.org/10.1016/j.tetlet.2016.06.068
Autor:
Jun O. Liu, Jennifer M. Fox, Nicole M. Anders, Patrick A. Brown, Gary H. Posner, Michelle A. Rudek, Ravit Arav-Boger, Bryan T. Mott, James R. Moynihan, Xiaochun Chen, Curt I. Civin, Jennifer R. Mazzone
Publikováno v:
Oncotarget
Artemisinins, endoperoxide-containing molecules, best known as antimalarials, have potent antineoplastic activity. The established antimalarial, artesunate (AS), and the novel artemisinin-derived trioxane diphenylphosphate dimer 838 (ART-838) inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99255128a0b19db047672be5a5c9ddb0
https://doi.org/10.18632/oncotarget.6896
https://doi.org/10.18632/oncotarget.6896
Autor:
Michael Forman, Sujayita Roy, Gary H. Posner, Ran He, Arun Kapoor, Ravit Arav-Boger, Jennifer R. Mazzone
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:3870-3879
Artemisinin-derived monomers and dimers inhibit human cytomegalovirus (CMV) replication in human foreskin fibroblasts (HFFs). The monomer artesunate (AS) inhibits CMV at micromolar concentrations, while dimers inhibit CMV replication at nanomolar con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0f2126cee057b7773bdac6fca4309d
https://doi.org/10.1128/aac.00262-15
https://doi.org/10.1128/aac.00262-15
Publikováno v:
Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry. 14:162-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2569eec3a1f80c00ea5a95bf60e96b5
https://doi.org/10.2174/187152221403150521105814
https://doi.org/10.2174/187152221403150521105814
Publikováno v:
Expert Review of Endocrinology & Metabolism. 9:283-292
Background: Human cultured osteoblasts from pre-Ob, post-Ob or m-Ob express different mRNAs and respond to different hormones. Aims: To test expression and hormonal modulation of VDR and 1OHase and 1,25D production in hObs. Methods: hObs obtained fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7a5933da61d241d02ebdff8d5125b8
https://doi.org/10.1586/17446651.2014.899897
https://doi.org/10.1586/17446651.2014.899897