Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Gary Grosser"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Three carriers of the solute carrier family SLC10 have been functionally characterized so far. Na+/taurocholate cotransporting polypeptide NTCP is a hepatic bile acid transporter and the cellular entry receptor for the hepatitis B and D viruses. Its
Externí odkaz:
https://doaj.org/article/50f697095c324c88874be5f26e09cb45
Autor:
Daniel I. Iliev, Regina Braun, Alberto Sánchez-Guijo, Michaela Hartmann, Stefan A. Wudy, Doreen Heckmann, Gernot Bruchelt, Anika Rösner, Gary Grosser, Joachim Geyer, Gerhard Binder
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Introduction: An increase of serum dehydroepiandrosterone (DHEA) sulfate (DHEAS) is observed in premature adrenarche and congenital adrenal hyperplasia. Very high DHEAS levels are typical for adrenal tumors. Approximately 74% of DHEAS is hydrolyzed t
Externí odkaz:
https://doaj.org/article/a24349d5abfe41a6932cb6aa9129d3fa
Autor:
Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto Sánchez-Guijo, Stefan A. Wudy, Joachim Geyer
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Estrogens play a pivotal role in the development and proliferation of hormone-dependent breast cancer. Apart from free estrogens, which can directly activate the estrogen receptor (ER) of tumor cells, sulfo-conjugated steroids, which maintain high pl
Externí odkaz:
https://doaj.org/article/02c02b5c18604a249c0adfa47d0f8aa8
Autor:
Daniela Fietz, Katharina Bakhaus, Britta Wapelhorst, Gary Grosser, Sabine Günther, Jörg Alber, Barbara Döring, Sabine Kliesch, Wolfgang Weidner, Christina E Galuska, Michaela F Hartmann, Stefan A Wudy, Martin Bergmann, Joachim Geyer
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62638 (2013)
Sulfated steroid hormones are commonly considered to be biologically inactive metabolites, but may be reactivated by the steroid sulfatase into biologically active free steroids, thereby having regulatory function via nuclear androgen and estrogen re
Externí odkaz:
https://doaj.org/article/9fc075712c1e4eab8423b993b41a08cd
Autor:
Katja Hartmann, Jens Neunzig, Alberto Sánchez-Guijo, Gary Grosser, Daniela Fietz, Joachim Geyer, Michaela F. Hartmann, Carina Blaschka, Rita Bernhardt, Christine Wrenzycki, Katharina Bakhaus, Dimitrios Papadopoulos, Martin Bergmann, Gerhard Schuler, Stefan A. Wudy, Mazen Shihan, Georgios Scheiner-Bobis, Y Dezhkam
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 172:207-221
Sulfated steroid hormones, such as dehydroepiandrosterone sulfate or estrone-3-sulfate, have long been regarded as inactive metabolites as they cannot activate classical steroid receptors. Some of them are present in the blood circulation at quite hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2f87e82c3752c2220c8e780de4c62b
https://doi.org/10.1016/j.jsbmb.2016.07.002
https://doi.org/10.1016/j.jsbmb.2016.07.002
Autor:
Gary Grosser, Joachim Geyer, Josefine Bennien, Barbara Döring, Katharina Bakhaus, Stefan A. Wudy, Alberto Sánchez-Guijo, Michaela F. Hartmann
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 179
The sodium-dependent organic anion transporter SOAT/Soat shows highly specific transport activity for sulfated steroids. SOAT substrates identified so far include dehydroepiandrosterone sulfate, 16α-hydroxydehydroepiandrosterone sulfate, estrone-3-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb23c47abe62a18aff664142f86625d9
https://pubmed.ncbi.nlm.nih.gov/28951227
https://pubmed.ncbi.nlm.nih.gov/28951227
Autor:
Sabine E. Kulling, Gary Grosser, Joachim Geyer, Bernhard Ugele, Sebastian T. Soukup, Barbara Döring
Publikováno v:
Archives of Toxicology. 89:2253-2263
Soy isoflavones (IF) are phytoestrogens, which interact with estrogen receptors. They are extensively metabolized by glucuronosyltransferases and sulfotransferases, leading to the modulation of their estrogenic activity. It can be assumed that this b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3802e18418813497a452b654b7e3dd67
https://doi.org/10.1007/s00204-014-1379-3
https://doi.org/10.1007/s00204-014-1379-3
Autor:
Ernst Petzinger, Bernhard Ugele, H. Schweigmann, Barbara Döring, Stefan A. Wudy, Gary Grosser, Michaela F. Hartmann, Joachim Geyer, Katja Hartmann, Alberto Sánchez-Guijo, Martin Bergmann, C. Pfarrer
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:259-265
16α-Hydroxy-dehydroepiandrosterone sulfate (16α-OH-DHEAS) mainly originates from the fetus and serves as precursor for placental estriol biosynthesis. For conversion of 16α-OH-DHEAS to estriol several intracellular enzymes are required. However, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd2f876e26506f262ae9ec82d0d1a2b
https://doi.org/10.1016/j.jsbmb.2014.03.013
https://doi.org/10.1016/j.jsbmb.2014.03.013
Autor:
Ernst Petzinger, Helene Schweigmann, Martin Bergmann, Ralph Brehm, Katharina Bakhaus, Daniela Fietz, Sabine Günther, Bernhard Ugele, Gary Grosser, Joachim Geyer
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 138:90-99
The sodium-dependent organic anion transporter SOAT is a member of the Solute Carrier Family SLC10. In man, this carrier is predominantly expressed in the testis and has transport activity for sulfoconjugated steroid hormones. Here, we report on clon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179519fb96da986292a2fbfaa1f36ac
https://doi.org/10.1016/j.jsbmb.2013.03.009
https://doi.org/10.1016/j.jsbmb.2013.03.009
Autor:
Gary Grosser, Joachim Geyer, Barbara Döring, Ernst Petzinger, Werner Kramer, Karl-Heinz Baringhaus
Publikováno v:
Molecular and cellular endocrinology. 428
The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. The present study aimed to identify novel specific SOAT inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444b86d52c6159c04f9e67f7df6e84c1
https://pubmed.ncbi.nlm.nih.gov/27033324
https://pubmed.ncbi.nlm.nih.gov/27033324