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Akademický článek

Identification of Drug-Induced Multichannel Block and Proarrhythmic Risk in Humans Using Continuous T Vector Velocity Effect Profiles Derived From Surface Electrocardiograms

Autor: Werner Bystricky, Christoph Maier, Gary Gintant, Dennis Bergau, David Carter

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

We present continuous T vector velocity (TVV) effect profiles as a new method for identifying drug effects on cardiac ventricular repolarization. TVV measures the temporal change in the myocardial action potential distribution during repolarization.

Externí odkaz: https://doaj.org/article/0c90d93c09594f8894a6ab34473884ed

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Akademický článek

International Multisite Study of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

Publikováno v: Cell Reports, Vol 24, Iss 13, Pp 3582-3592 (2018)

Summary: To assess the utility of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an in vitro proarrhythmia model, we evaluated the concentration dependence and sources of variability of electrophysiologic responses to 28 dr

Externí odkaz: https://doaj.org/article/3766b15437f1454ca223759395ad3b34

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Akademický článek

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Autor: Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Alexandre J. S. Ribeiro, Tanja Zabka, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclini

Externí odkaz: https://doaj.org/article/e6b42e00ab1d407c9c50c66883fb0686

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Akademický článek

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Autor: Alexandre J. S. Ribeiro, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provid

Externí odkaz: https://doaj.org/article/2e22341d9929407fb056d39646d70fe3

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Akademický článek

T vector velocity: A new ECG biomarker for identifying drug effects on cardiac ventricular repolarization.

Autor: Werner Bystricky, Christoph Maier, Gary Gintant, Dennis Bergau, Kent Kamradt, Patrick Welsh, David Carter

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0204712 (2019)

BackgroundWe present a new family of ECG biomarkers for assessing drug effects on ventricular repolarization. We show that drugs blocking inward (depolarizing) ion currents cause a relative increase of the T vector velocity (TVV) and accelerate repol

Externí odkaz: https://doaj.org/article/11f4a5406d914d2eb5d9f29f26269b9a

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Akademický článek

Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI)

Autor: Thivanka Muthumalage, Michelle R. Friedman, Matthew D. McGraw, Gary Ginsberg, Alan E. Friedman, Irfan Rahman

Publikováno v: Toxics, Vol 8, Iss 2, p 25 (2020)

The Centers for Disease Control declared e-cigarette, or vaping, product use-associated lung injury (EVALI) a national outbreak due to the high incidence of emergency department admissions and deaths. We have identified chemical constituents in e-cig

Externí odkaz: https://doaj.org/article/48c7e648e81344eab015a72e27162a5c

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Glucose metabolism by rat pancreatic islets in vitro

Autor: Gary Gin, Harvey M. Rodman, Bernard R. Landau, James W. Craig, Andy C. Reese

Publikováno v: Metabolism. 22:467-472

[U-14C]-glucose was incubated with rat islets in a Krebs-Ringer buffer. The uptake of glucose and its oxidation to CO2 were in accord with linear increases over the range of medium concentration of glucose from 0.6–3.0 mg/ml. Uptake was similar at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80a5b4131d19c64585c73f217458c74
https://doi.org/10.1016/0026-0495(73)90038-3

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Akademický článek

Auditory stimulation improves motor function and caretaker burden in children with cerebral palsy- A randomized double blind study.

Autor: Hilla Ben-Pazi, Adi Aran, Anand Pandyan, Nava Gelkop, Gary Ginsberg, Yehuda Pollak, Debby Elnatan

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0208792 (2018)

AIM:To investigate the impact of auditory stimulation on motor function in children with cerebral palsy (CP) and disabling hypertonia. METHOD:9 matched pairs (age: 7y5m, SD 4y1m; 13 boys; gross-motor-functional-classification-scale: median 4; manual-

Externí odkaz: https://doaj.org/article/39e4d1466af2481a99be4b41cf3f563a

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