Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Gary G. Mather"'
Autor:
Rita Labroo, Marie‐Emmanuelle Le Guern, Francis Lepage, René H. Levy, Jean-Marie Gillardin, Gary G. Mather
Publikováno v:
Chirality. 12:153-159
Nefopam (NEF) is a potent analgesic compound administered as a racemic mixture. Previous in vitro and in vivo studies with nefopam enantiomers have shown that (+)nefopam [(+)NEF] is substantially more potent than (−)nefopam [(−)NEF]. Differences
Publikováno v:
Biochemical Pharmacology. 58:455-459
A previous study showed that valproic acid (VPA) and tumor necrosis factor-α (TNF-α) exhibit synergistic toxicity (lethality) in Sprague–Dawley and Wistar rats. The present study investigated a possible mechanism for this synergy using an in vitr
Autor:
William Lyness, J. Morganroth, J. E. Harr, A. Rosenberg, William F. Trager, James L. Perhach, René H. Levy, Gary G. Mather
Publikováno v:
The Journal of Clinical Pharmacology. 37:1065-1072
Azelastine, an antihistamine with additional pharmacologic properties, was evaluated for a possible influence on pharmacokinetic and electrocardiographic parameters due to its coadministration with CYP3A4 inhibitor ketoconazole (200 mg every 12 hrs).
Publikováno v:
Immunobiology. 182:205-215
Cyclosporine A (CsA) was used to immunosuppress male Sprague-Dawley rats treated with the chemical carcinogen 3-methylcholanthrene (3MC).Rats treated with low doses of CsA (2.5 or 5 mg/kg) given 2 days prior to an injection of 3MC, and then daily for
Publikováno v:
Fundamental and Applied Toxicology. 16:830-840
Male Sprague-Dawley rats were exposed to either 2000 or 6000 ppm of 2-methoxyethanol (ME) or 2-butoxyethanol (BE) and females were exposed to either 1600 or 4800 ppm of these compounds in the drinking water for 21 days. Body weights were decreased in
Publikováno v:
Immunopharmacology and Immunotoxicology. 13:47-64
Seven-week-old male Sprague-Dawley rats were given a single injection of 1.5 mg of 3-methylcholanthrene (3MC) to induce in situ fibrosarcomas. The rats were also treated with the dopamine agonist bromocriptine (BCR) from two days prior to 14 days aft
Publikováno v:
Toxicology. 64:71-80
Male Sprague-Dawley rats were treated with either dichloroacetic acid (DCA) or trichloroacetic acid (TCA) in the drinking water at levels of 0, 50, 500 and 5000 ppm for a period of 90 days to determine the toxicities associated with subchronic exposu
Autor:
Donna Bergen, William R. Garnett, Isabelle Ragueneau-Majlessi, John S. Grundy, William E. Rosenfeld, Jaymin Shah, Gary G. Mather, René H. Levy
Publikováno v:
Epilepsy research. 62(1)
Carbamazepine is metabolized by CYP3A4 and several other cytochrome P450 enzymes. The potential effects of zonisamide on carbamazepine pharmacokinetics (PK) have not been well characterized, with contradictory literature reports. Hence, an in vitro s
Autor:
William F. Trager, Rajesh C. Sachdeo, RenéH. Levy, F.E. Bishop, S. K. Sachdeo, Anthony J. Streeter, Christopher Curtin, Gary G. Mather, Danny D. Shen, Meir Bialer, Kent L. Kunze, L.K. Roskos, Kenneth E. Thummel, Dennis R. Doose, L. G. Gisclon
Publikováno v:
Epilepsia. 43(7)
Summary: Purpose: To evaluate the potential pharmacokinetic interactions between topiramate (TPM) and phenytoin (PHT) in patients with epilepsy by studying their pharmacokinetics (PK) after monotherapy and concomitant TPM/PHT treatment. Methods: Twel
Autor:
Gregory D. Bennett, Bogdan J. Wlodarczyk, Manoj Bajpai, Richard H. Finnell, René H. Levy, Gary G. Mather
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 13(2)
Purpose: Previous studies have suggested that polytherapy by design may aid in the management of human pregnancies complicated by epilepsy. However, mechanistic parallels must be drawn between the models of teratogenesis and human pregnancies, and do