Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Gary G. Chiang"'
Autor:
Adina Gerson-Gurwitz, Nathan P. Young, Vikas K. Goel, Boreth Eam, Craig R. Stumpf, Joan Chen, Sarah Fish, Maria Barrera, Eric Sung, Jocelyn Staunton, Gary G. Chiang, Kevin R. Webster, Peggy A. Thompson
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Oncoprotein expression is controlled at the level of mRNA translation and is regulated by the eukaryotic translation initiation factor 4F (eIF4F) complex. eIF4A, a component of eIF4F, catalyzes the unwinding of secondary structure in the 5’-untrans
Externí odkaz:
https://doaj.org/article/3c591166c36f4888bb12e979b6ceb351
Autor:
Sujata Jana, Rucha Deo, Rowan P. Hough, Yuzhen Liu, Jessie L. Horn, Jonathan L. Wright, Hung-Ming Lam, Kevin R. Webster, Gary G. Chiang, Nahum Sonenberg, Andrew C. Hsieh
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Using genetically engineered mouse models, this work demonstrates that protein synthesis is essential for efficient urothelial cancer formation and growth but dispensable for bladder homeostasis. Through a candidate gene analysis for translation regu
Externí odkaz:
https://doaj.org/article/2f23ca10819f4654a2a0748a88d95c63
Autor:
Duygu Kuzuoglu-Ozturk, Zhiqiang Hu, Martina Rama, Emily Devericks, Jacob Weiss, Gary G. Chiang, Stephen T. Worland, Steven E. Brenner, Hani Goodarzi, Luke A. Gilbert, Davide Ruggero
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109321- (2021)
Summary: The major cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), an ancient protein required for translation of all eukaryotic genomes, is a surprising yet potent oncogenic driver. The genetic interactions that maintain the
Externí odkaz:
https://doaj.org/article/18d631e8c9eb45e2897410bdd7687c18
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
The PI3K/AKT/mTOR pathway is often activated in lymphoma through alterations in PI3K, PTEN, and B-cell receptor signaling, leading to dysregulation of eIF4A (through its regulators, eIF4B, eIF4G, and PDCD4) and the eIF4F complex. Activation of eIF4F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1650a320f50adfe95d94d63fa8b72d9e
https://doi.org/10.1158/1535-7163.c.6542892.v1
https://doi.org/10.1158/1535-7163.c.6542892.v1
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Structures and PC3 viability IC50 data for compounds in Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450290df0d613596edbab94a5a07a69
https://doi.org/10.1158/1535-7163.22503433.v1
https://doi.org/10.1158/1535-7163.22503433.v1
Autor:
Chris Tse, Charles Brenner, Saul H. Rosenberg, Wenqing Gao, Gary G. Chiang, F. Gregory Buchanan, David Maag, Michael R. Michaelides, Michael L. Curtin, Ilaria Badagnani, Shaun M. McLoughlin, Paul L. Richardson, Hua Tang, Vivek C. Abraham, Danli L. Towne, Steven Cepa, Alla V. Korepanova, Diana Raich, Kenton L. Longenecker, T. Matthew Hansen, Richard F. Clark, Bryan K. Sorensen, H. Robin Heyman, Sujatha Selvaraju, Yupeng He, Peter J. Kovar, Stormy L. Koeniger, Jun Guo, Yan Shi, Samuel A.J. Trammell, Dong Cheng, Min Cheng, Julie L. Wilsbacher
Supplementary methods, tables S1-S3, and supplementary figures 1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e7619544c11452e1775f6d92101867
https://doi.org/10.1158/1535-7163.22503430.v1
https://doi.org/10.1158/1535-7163.22503430.v1
Autor:
Kevin R. Webster, Siegfried H. Reich, Justin T. Ernst, Paul A. Sprengeler, Chinh Tran, Theodore Michels, Garrick K. Packard, Christian Nilewski, Alan Xiang, Samuel Sperry, Jeff Clarine, Andres Nevarez, Christopher J. Wegerski, Adina Gerson-Gurwitz, Gary G. Chiang, Jocelyn Staunton, Ana Parra, Eric Sung, Haleigh Howard, Maria Barrera, Joan Chen, Sarah Fish, Nathan P. Young, Boreth Eam, Peggy A. Thompson
Tables S1-S3, Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b76301f84d3ad65de199ac1ded585c
https://doi.org/10.1158/1535-7163.22521054.v1
https://doi.org/10.1158/1535-7163.22521054.v1
Autor:
Jeffrey M. Arbeit, Gordon B. Mills, Gary G. Chiang, Stan Krajewski, Dong Fan, Raleigh D. Kladney, Mollianne M. Murray, Jenny M. Shao, Andrew Y. Lee, Mark B. Shvartsman, Zhi Hong Lu
Supplementary Figure 6 from Mammalian Target of Rapamycin Activator RHEB Is Frequently Overexpressed in Human Carcinomas and Is Critical and Sufficient for Skin Epithelial Carcinogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4b191873c819ac589dae405f4cea47
https://doi.org/10.1158/0008-5472.22386771
https://doi.org/10.1158/0008-5472.22386771
Autor:
Zhi Hong Lu, Jeffrey M. Arbeit, Jason D. Weber, Gary G. Chiang, David J. Kwiatkowski, Robert D. Cardiff, Raleigh D. Kladney
Supplementary Figure Legends 1-5 from Tuberous Sclerosis Complex 1: An Epithelial Tumor Suppressor Essential to Prevent Spontaneous Prostate Cancer in Aged Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877ab69b13cfeb5fb950a3a5060fb8bc
https://doi.org/10.1158/0008-5472.22385013
https://doi.org/10.1158/0008-5472.22385013
Autor:
Jeffrey M. Arbeit, Gordon B. Mills, Gary G. Chiang, Stan Krajewski, Dong Fan, Raleigh D. Kladney, Mollianne M. Murray, Jenny M. Shao, Andrew Y. Lee, Mark B. Shvartsman, Zhi Hong Lu
RHEB cancer expression and clinico-pathological data from Mammalian Target of Rapamycin Activator RHEB Is Frequently Overexpressed in Human Carcinomas and Is Critical and Sufficient for Skin Epithelial Carcinogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceec971d3d2975a66233d3f45b5bd83
https://doi.org/10.1158/0008-5472.22386789
https://doi.org/10.1158/0008-5472.22386789