Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gary G. Cao"'
Autor:
Ying Wang, Jack Krupinski, Gary G. Cao, Xiaoliang Zhuo, Joseph Carpenter, Erica Cook, Milinda Ziegler, Karen A. Rossi, Anthony V. Azzara, Kathy Mosure, Gang Wu, Matthew G. Soars, Dean A. Wacker, Bruce A. Ellsworth, Doree F. Sitkoff, Tao Wang
Publikováno v:
ACS Med Chem Lett
[Image: see text] Herein we report the discovery and preclinical biological evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce42c1d64be61d8389ebf3b9000ba19f
https://doi.org/10.1021/acsmedchemlett.1c00198
https://doi.org/10.1021/acsmedchemlett.1c00198
Autor:
Susheel J. Nara, Srinivas Jogi, Srinivas Cheruku, Sarkunam Kandhasamy, Firoz Jaipuri, Pavan Kalyan Kathi, Subba Reddy, Sanket Sarodaya, Erica M. Cook, Tao Wang, Doree Sitkoff, Karen A. Rossi, Max Ruzanov, Susan E. Kiefer, Javed A. Khan, Mian Gao, Satyanarayana Reddy, Sankara Sivaprasad LVJ, Ramola Sane, Kathy Mosure, Xiaoliang Zhuo, Gary G. Cao, Milinda Ziegler, Anthony Azzara, John Krupinski, Matthew G. Soars, Bruce A. Ellsworth, Dean A. Wacker
Publikováno v:
Journal of medicinal chemistry. 65(13)
While several farnesoid X receptor (FXR) agonists under clinical investigation for the treatment of nonalcoholic steatohepatitis (NASH) have shown beneficial effects, adverse effects such as pruritus and elevation of plasma lipids have limited their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950a84b56e656ee81f551db19a874f2a
https://pubmed.ncbi.nlm.nih.gov/35704802
https://pubmed.ncbi.nlm.nih.gov/35704802
Autor:
Gary G. Cao, Min Zhou, Ramya Jayaram, Douglas B. Moore, Andres S. Hernandez, Tao Wang, Jean M. Whaley, Yue-Zhong Shu, Carrie Xu, Lori Kunselman, Atsu Apedo, William R. Ewing, Reshma Panemangalore, Qi Gao, Arvind Mathur, Richard Rampulla, Bradley A. Zinker, Lauren Haque, Mary Ellen Cvijic, Marta Dabros, Arun Kumar Gupta, Heng Liu, Jeffrey A. Robl, Bruce A. Ellsworth, Jun Shi, Zhengxiang Gu, Jason J. Wilkes, Akin H. Davulcu, Kristin N. Williams, Elizabeth A. Dierks, John Krupinski, Zhenqiu Hong, Edward J. Brady, Ximao Wu, Qin Sun, Hong Cai, Chunshan Xie, Elizabeth A. Jurica, Kimberly A. Foster
Publikováno v:
Journal of medicinal chemistry. 61(3)
G protein-coupled receptor 40 (GPR40) has become an attractive target for the treatment of diabetes since it was shown clinically to promote glucose-stimulated insulin secretion. Herein, we report our efforts to develop highly selective and potent GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbe81ca0de7013eecb9cd7ee4d58d5d
https://pubmed.ncbi.nlm.nih.gov/29316397
https://pubmed.ncbi.nlm.nih.gov/29316397
Autor:
Lin HY; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States. Electronic address: hlin@ordwayresearch.org., Tang HY; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States., Shih A; National Laboratory Animal Center, National Applied Research Laboratory, Nakang, Taipei, Taiwan., Keating T; Research Service, Stratton VA Medical Center, United States., Cao G; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States., Davis PJ; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States; The Wadsworth Center, New York State Department of Health, Albany, NY, United States., Davis FB; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States.
Publikováno v:
Steroids [Steroids] 2023 Jul; Vol. 195, pp. 109237. Date of Electronic Publication: 2023 Apr 11.
Autor:
Jurica EA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States. Electronic address: Elizabeth.Jurica@bms.com., Wu X; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Williams KN; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Haque LE; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Rampulla RA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Mathur A; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Zhou M; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Cao G; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Cai H; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Wang T; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Liu H; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Xu C; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Kunselman LK; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Antrilli TM; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Hicks MB; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Sun Q; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Dierks EA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Apedo A; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Moore DB; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Foster KA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Cvijic ME; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Panemangalore R; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Khandelwal P; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Wilkes JJ; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Zinker BA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Robertson DG; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Janovitz EB; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Galella M; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Li YX; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Li J; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Ramar T; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Jalagam PR; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Jayaram R; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Whaley JM; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Barrish JC; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Robl JA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Ewing WR; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States., Ellsworth BA; Research and Development, Bristol Myers Squibb, Co., P.O. Box 4000, Princeton, NJ 08543-4000, United States.
Publikováno v:
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 May 01; Vol. 85, pp. 117273. Date of Electronic Publication: 2023 Apr 04.
Autor:
Lin HY; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States. Electronic address: linhy@tmu.edu.tw., Tang HY; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States., Shih A; National Laboratory Animal Center, National Applied Research Laboratory, Nakang, Taipei, Taiwan., Keating T; Research Service, Stratton VA Medical Center, United States., Cao G; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States., Davis PJ; Research Service, Stratton VA Medical Center, United States; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States; The Wadsworth Center, New York State Department of Health, Albany, NY, United States., Davis FB; Signal Transduction Laboratory, Ordway Research Institute, Albany, NY, United States.
Publikováno v:
Steroids [Steroids] 2022 Nov; Vol. 187, pp. 109111. Date of Electronic Publication: 2022 Oct 01.
Autor:
Han Z; Department of Cardiovascular and Fibrosis Discovery Biology, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Ma Y; Department of Cardiovascular and Fibrosis Discovery Biology, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Cao G; Department of Cardiovascular and Fibrosis Discovery Biology, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Ma Z; Department of Cardiovascular and Fibrosis Discovery Biology, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Chen R; Department of Lead Discovery and Optimization, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Cvijic ME; Department of Lead Discovery and Optimization, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A., Cheng D; Department of Cardiovascular and Fibrosis Discovery Biology, Research and Development, Bristol Myers Squibb Company, Princeton, NJ 08540, U.S.A.
Publikováno v:
The Biochemical journal [Biochem J] 2021 May 14; Vol. 478 (9), pp. 1689-1703.
Autor:
Jurica EA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Wu X; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Williams KN; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Hernandez AS; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Nirschl DS; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Rampulla RA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Mathur A; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Zhou M; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Cao G; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Xie C; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Jacob B; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Cai H; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Wang T; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Murphy BJ; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Liu H; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Xu C; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Kunselman LK; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Hicks MB; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Sun Q; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Schnur DM; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Sitkoff DF; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Dierks EA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Apedo A; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Moore DB; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Foster KA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Cvijic ME; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Panemangalore R; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Flynn NA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Maxwell BD; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Hong Y; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Tian Y; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Wilkes JJ; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Zinker BA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Whaley JM; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Barrish JC; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Robl JA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Ewing WR; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States., Ellsworth BA; Research and Development, Bristol-Myers Squibb, Co. , P.O. Box 4000, Princeton, New Jersey 08540-4000, United States.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1417-1431. Date of Electronic Publication: 2017 Feb 09.