Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Gary G Meadows"'
Autor:
Sang Su Kwak, Mikyoung Jeong, Ji Hye Choi, Daesoo Kim, Hyesun Min, Yoosik Yoon, Onyou Hwang, Gary G Meadows, Cheol O Joe
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60803 (2013)
This study reports an amelioration of abnormal motor behaviors in tetrahydrobiopterin (BH4)-deficient Spr (-/-) mice by the dietary supplementation of tyrosine. Since BH4 is an essential cofactor for the conversion of phenylalanine into tyrosine as w
Externí odkaz:
https://doaj.org/article/18c8cbd401434201a96802813f866fd9
Autor:
Sang Su Kwak, Jeung-Hoon Lee, Jin Woo Kim, Kyung Hwa Kang, Gary G. Meadows, Cheol O. Joe, SeoEun Lee, Seyun Kim, Boohyeong Byun
Publikováno v:
Cellular Signalling. 28:32-41
We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. While NPRL2 interacts with Rag GTPases, R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2a75d6b90f29983558f67c67dfbc18
https://doi.org/10.1016/j.cellsig.2015.11.008
https://doi.org/10.1016/j.cellsig.2015.11.008
Publikováno v:
International Immunopharmacology. 28:359-368
Alcohol consumption increases the incidence of multiple types of cancer. However, how chronic alcohol consumption affects tumor progression and host survival remains largely unexplored. Using a mouse B16BL6 melanoma model, we studied the effects of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed5634d978a474b9b16a0a731db5679
https://doi.org/10.1016/j.intimp.2015.06.018
https://doi.org/10.1016/j.intimp.2015.06.018
Publikováno v:
Toxicology and Applied Pharmacology. 282:139-150
Alcohol consumption exhibits diverse effects on different types of immune cells. NKT cells are a unique T cell population and play important immunoregulatory roles in different types of immune responses. The effects of chronic alcohol consumption on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bec20d7d128e00abd7c134afdaa26e
https://doi.org/10.1016/j.taap.2014.11.013
https://doi.org/10.1016/j.taap.2014.11.013
Publikováno v:
Journal of Studies on Alcohol and Drugs. 73:933-937
The effects of alcohol (ethanol) are well documented and contribute to significant health problems and financial burden on the health care system. Several mouse models have been described that facilitate studies of the effects of alcohol on the mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c82e808497e84e7f9f85f504dcf9de
https://doi.org/10.15288/jsad.2012.73.933
https://doi.org/10.15288/jsad.2012.73.933
Publikováno v:
The Journal of Immunology. 189:1340-1348
Accumulating research indicates that B cells are involved in anti-tumor immunity. Chronic alcohol consumption is associated with decreased survival of cancer patients. The effect of alcohol consumption on B cells in tumor-bearing hosts is unknown. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afc1ccc58d9a2e734c44642b125cec6
https://doi.org/10.4049/jimmunol.1200442
https://doi.org/10.4049/jimmunol.1200442
Autor:
Gary G. Meadows
Publikováno v:
Cancer and Metastasis Reviews. 31:441-454
The major factor in the morbidity and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches to control metastasis, and this is a fruitful area for investigation. A healthy diet and lifestyle not o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e676228cb23273f2c9d86e2ea46940
https://doi.org/10.1007/s10555-012-9369-5
https://doi.org/10.1007/s10555-012-9369-5
Autor:
Xingqi Zhang, Gary G. Meadows, Ni Lan, Joanne Weinberg, David W. Nordstokke, Wayne Yu, Linda Ellis, Paxton Bach
Publikováno v:
Brain, Behavior, and Immunity. 26:439-450
Prenatal alcohol exposure (PAE) has adverse effects on the development of numerous physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis and the immune system. HPA hyper-responsiveness and impairments in immune competence hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78d342baaac061a4e55faa1f4b2387a
https://doi.org/10.1016/j.bbi.2011.11.005
https://doi.org/10.1016/j.bbi.2011.11.005
Autor:
Jin Woo Kim, Yong Hee Hong, Ya-Min Fu, Jinkyu Suk, Jeong Keun Ahn, Seungkyung Yang, Jae Hoon Chung, Cheol O. Joe, Hyesun Min, Sang Su Kwak, Ji Hye Choi, Dong Hwan Lee, Gary G. Meadows, Seonghyang Sohn
Publikováno v:
Autophagy. 7:1323-1334
Tetrahydrobiopterin (BH₄) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article, the signaling pathway by which BH₄ deficiency inactivates mTORC1 leading to the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa8257563736baffebd881777de4683
https://doi.org/10.4161/auto.7.11.16627
https://doi.org/10.4161/auto.7.11.16627
Publikováno v:
Toxicological Sciences. 124:291-298
Treatment with aryl hydrocarbon receptor (AhR) agonists can slow or reverse the growth of primary mammary tumors in rodents, which has fostered interest in developing selective AhR modulators for treatment of breast cancer. However, the major goal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ed07ec951d89b3a1f4ef8d5bc31957
https://doi.org/10.1093/toxsci/kfr247
https://doi.org/10.1093/toxsci/kfr247