Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Gary E. Zurenko"'
Publikováno v:
Clinical Infectious Diseases. 58:S35-S42
The emerging antibiotic resistance of Gram-positive pathogens represents a significant challenge to the management of human infections. The novel oxazolidinone tedizolid demonstrates antimicrobial activity across a broad range of Gram-positive pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1712d91ae32f8b727f0660b52c2511fd
https://doi.org/10.1093/cid/cit616
https://doi.org/10.1093/cid/cit616
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3236-3239
TR-701 is the prodrug of the microbiologically active molecule TR-700, a novel orally and intravenously administered oxazolidinone antibacterial agent. The in vitro activity of TR-700 was evaluated against 1,063 bacterial clinical isolates including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb327708465baf65e0153d37a1d9d3ea
https://doi.org/10.1128/aac.00228-09
https://doi.org/10.1128/aac.00228-09
Autor:
Vickie Brown-Driver, Dean L. Shinabarger, Karen Joy Shaw, Gary E. Zurenko, Chris M. Pillar, John T. Finn, S. Poppe, Ronda D. Schaadt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4442-4447
TR-701 is the orally active prodrug of TR-700, a novel oxazolidinone that demonstrates four- to eightfold-greater activity than linezolid (LZD) against Staphylococcus and Enterococcus spp. In this study evaluating the in vitro sensitivity of LZD-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e80b4c184dadc7ae40e60a2568a351
https://doi.org/10.1128/aac.00859-08
https://doi.org/10.1128/aac.00859-08
Autor:
Mark C. Sulavik, Ji-Young Kim, Rose Kelly, Allison Laura Choy, Roger J. Brideau, Poel Toni-Jo, Joanne Brodfuehrer, Gary E. Zurenko, Tong Zhu, Michael Dority, Cai Hongliang, Barbachyn Michael R, Joan K. Brieland, Thomas Richard C, Frederick E. Boyer, Michael R. Dermyer, Martin Joseph P, Michael D. Huband, Alan P. Brown, Daniel E. Ross, Debra Hanna, Laura A. Skerlos, Robert C. Gadwood, Wade J. Adams, Paul J. Pagano, Aristoff Paul A, Christopher Huber, J.V.N. Vara Prasad, Charles W. Ford
Publikováno v:
Journal of Medicinal Chemistry. 50:5886-5889
Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9719ee4eadbecc05b31ebef68614436
https://doi.org/10.1021/jm070708p
https://doi.org/10.1021/jm070708p
Autor:
Gregg M. Kamilar, Gary E. Zurenko, J. Craig Ruble, Earline P. Melchior, Keith R. Marotti, Michael T. Sweeney, Brian D. Wakefield, Donna L. Romero
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4040-4043
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure-activity relationships around the carboxylic acid subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cec89d15f824414a1582a4e936e43cf
https://doi.org/10.1016/j.bmcl.2007.04.074
https://doi.org/10.1016/j.bmcl.2007.04.074
Autor:
Gary E. Zurenko, Keith R. Marotti, Atli Thorarensen, Ronald W. Sarver, Michael T. Sweeney, Donna L. Romero, Brian D. Wakefield, Jianke Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3113-3116
In the past few years a significant effort has been devoted by Pharmacia toward the discovery of novel antibiotics. We have recently described the identification of an anthranilic acid lead 1 and the optimization resulting in the advanced lead 2. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a868674bc0ee08e9ffbd1dd19641fb
https://doi.org/10.1016/j.bmcl.2007.03.036
https://doi.org/10.1016/j.bmcl.2007.03.036
Autor:
Michael T. Sweeney, Donna L. Romero, Garold L. Bryant, Gary E. Zurenko, Fusen Han, Douglas C. Rohrer, Atli Thorarensen, Keith R. Marotti, Brian D. Wakefield
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2823-2827
In the past few years, a significant effort has been devoted by Pharmacia toward the discovery of novel antibiotics. We have recently described the identification of an anthranilic acid lead 1 and the optimization resulting in the advanced lead 2. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aed26bc736179ec98daa61b460e39c8
https://doi.org/10.1016/j.bmcl.2007.02.055
https://doi.org/10.1016/j.bmcl.2007.02.055
Autor:
Douglas C. Rohrer, Cory M. Stiff, Jianke Li, Brian D. Wakefield, Keith R. Marotti, Michael T. Sweeney, Donna L. Romero, Gary E. Zurenko, J. Craig Ruble, Atli Thorarensen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2347-2350
Discovery of novel antibacterial agents is a significant challenge. We have recently reported on our discovery of novel antibacterial agents in which we have rapidly optimized potency utilizing a parallel chemistry approach. These advanced leads suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154591ae032549d198cd4af88e21ee11
https://doi.org/10.1016/j.bmcl.2006.12.055
https://doi.org/10.1016/j.bmcl.2006.12.055
Autor:
Anthony W. Yem, W. Rodney Mathews, Atli Thorarensen, Michael John Bohanon, Michael T. Sweeney, Timothy P. Boyle, Cindy L Wolfe, Charlotte L. Heckaman, Keith R. Marotti, Martin R. Deibel, Alice L. Bodnar, Gary E. Zurenko
Publikováno v:
Bioconjugate Chemistry. 15:333-343
Screening of our compound collection identified PNU-92560, a 2-[1,3,4]thiadiazolo[3,2-a]pyrimidine-6-carboxamide, as a novel antibacterial agent. Extensive analogue development identified that the 2-position of the thiadiazole could be functionalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0c2db2a4032ea752680f6270b9b835
https://doi.org/10.1021/bc034060g
https://doi.org/10.1021/bc034060g
Autor:
Janice M. Friis, Charlotte Wu, Sara E. Morin, Joaquim Trias, Bore Raju, Wade J. Adams, Ford Charles W, Ronda D. Schaadt, Stuart Lam, Joe Palandra, Dinesh V. Patel, Joseph Zhou, Maria Courtney, Mikhail F. Gordeev, Sara Lopez, Gary E. Zurenko, C J Hackbarth, Upinder Singh, Robert C. Gadwood, Zhengyu Yuan, Kathleen Mortell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4209-4212
Combinatorial libraries of N-acylated 5-(S)-aminomethyloxazolidinone derivatives of S-oxide and S,S-dioxide tetrahydro-4(2H)-thiopyranyl and thiomorpholine phenyloxazolidinone series have been synthesized on a solid phase and evaluated for antimicrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2c3baddccd9423c1209ad56d9a34c7
https://doi.org/10.1016/j.bmcl.2003.07.022
https://doi.org/10.1016/j.bmcl.2003.07.022