Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Gary E. Shull"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Loss of the AE3 Cl−/HCO3 − exchanger (Slc4a3) in mice causes an impaired cardiac force-frequency response and heart failure under some conditions but the mechanisms are not known. To better understand the functions of AE3, we performed R
Externí odkaz:
https://doaj.org/article/a36ff633f7eb4c8c93650c8f1bfceaa9
Publikováno v:
Cellular Physiology and Biochemistry, Vol 32, Iss 1, Pp 111-128 (2013)
Background: The mechanisms bacteria use to proliferate and alter the normal bacterial composition remain unknown. The ability to link changes in the intestinal micro-environment, such as ion composition and pH, to bacterial proliferation is clinicall
Externí odkaz:
https://doaj.org/article/60c147d9c55a406f945fd00b12f327f4
Publikováno v:
Am J Physiol Renal Physiol
The molecular mechanisms regulating ammonia metabolism are fundamental to acid-base homeostasis. Deletion of the A splice variant of Na(+)-bicarbonate cotransporter, electrogenic, isoform 1 (NBCe1-A) partially blocks the effect of acidosis to increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dd1c421e65796119b857973e377d00
https://doi.org/10.1152/ajprenal.00358.2021
https://doi.org/10.1152/ajprenal.00358.2021
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158893 (2016)
Anion exchanger 2 (Ae2; gene symbol, Slc4a2) is a plasma membrane Cl-/HCO3- exchanger expressed in the gastrointestinal tract, kidney and bone. We have previously shown that Ae2 is required for the function of osteoclasts, bone resorbing cells of the
Externí odkaz:
https://doaj.org/article/11a75978f0cd4f69a0dcdb0a5439d373
Autor:
Seyi E. Elasoru, Rui Zhang, Raven Norris, Sabine Lotteau, Joice Gavali, Liang Li, Gary E. Shull, Kenneth D. Philipson, Michela Ottolia, Joshua I. Goldhaber
Publikováno v:
Biophysical Journal. 122:164a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3847333fefc300cfb693ac95c1ade7fa
https://doi.org/10.1016/j.bpj.2022.11.1039
https://doi.org/10.1016/j.bpj.2022.11.1039
Publikováno v:
The Journal of physiology. 600(9)
Regulation of intracellular pH (pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a82f938ea553c759a8e19a0ee3317a8
https://pubmed.ncbi.nlm.nih.gov/35490392
https://pubmed.ncbi.nlm.nih.gov/35490392
Publikováno v:
Circulation. 144
Regulation of intracellular pH (pH i ) in cardiomyocytes is crucial for cardiac function; however, currently known mechanisms for direct or indirect extrusion of acid from cardiomyocytes seem insufficient for energetically-efficient extrusion of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff7a19dab302463907c81cdcf38a99a9
https://doi.org/10.1161/circ.144.suppl_1.11169
https://doi.org/10.1161/circ.144.suppl_1.11169
Autor:
Michael F. Romero, Y. S. Prakash, Satish Sen, Gary E. Shull, Matthew R. Brown, Alison A. Stiller, Aleksey V. Matveyenko, Heather L. Holmes, Naureen Javeed, Kuntol Rakshit, Tracy K. Her
Publikováno v:
J Clin Invest
Pancreatic β cell failure in type 2 diabetes mellitus (T2DM) is attributed to perturbations of the β cell’s transcriptional landscape resulting in impaired glucose-stimulated insulin secretion. Recent studies identified SLC4A4 (a gene encoding an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623cb5ac371912498eaf1c803d9f5b61
https://doi.org/10.1172/jci142365
https://doi.org/10.1172/jci142365
Autor:
Meghali P Nighot, Prashant K Nighot, Thomas Y Ma, Danuta H Malinowska, Gary E Shull, John Cuppoletti, Anthony T Blikslager
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138174 (2015)
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, parietal cell abundance, H/K ATPase expression, parietal cell ultrastructure and acid secretion using WT and ClC-2-/- mouse stomachs. Cellular histolog
Externí odkaz:
https://doaj.org/article/177186bc2cbb4f79acdc6d88009881ef
Autor:
Vikram ePrasad, John N Lorenz, Valerie M Lasko, Michelle L Nieman, Nabeel J Al Moamen, Gary E Shull
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Cl-/HCO3- exchangers are expressed abundantly in cardiac muscle, suggesting that HCO3- extrusion serves an important function in heart. Mice lacking Anion Exchanger Isoform 3 (AE3), a major cardiac Cl-/HCO3- exchanger, appear healthy, but loss of AE3
Externí odkaz:
https://doaj.org/article/23a775aa6bbf4143b7558a259360bfe6