Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Gary E. Isom"'
The basic and applied toxicology of cyanides and cyanogens has widespread commercial, occupational, environmental, clinical, forensic, military, and public health implications. This book provides a detailed and updated reference describing the proper
Autor:
Joseph L. Borowitz, Gary E. Isom
Publikováno v:
Toxicology of Cyanides and Cyanogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4853bacea4c548e10fd18cf16a9d0005
https://doi.org/10.1002/9781118628966.ch5
https://doi.org/10.1002/9781118628966.ch5
Publikováno v:
Toxicology of Cyanides and Cyanogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e669b418c2d5427161eecb5d5eb038d
https://doi.org/10.1002/9781118628966.ch4
https://doi.org/10.1002/9781118628966.ch4
Autor:
Joseph L. Borowitz, Gary E. Isom
Publikováno v:
Toxicology of Cyanides and Cyanogens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3292d96e8bafa9d2c3547bfc5680911d
https://doi.org/10.1002/9781118628966.ch15
https://doi.org/10.1002/9781118628966.ch15
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:97-105
Cyanide is a potent neurotoxicant that can produce dopaminergic neuronal death in the substantia nigra and is associated with a Parkinson-like syndrome. In this study involvement of Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a BH3-onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07233008be62592ec73ac7894e5543ed
https://doi.org/10.1124/jpet.109.159103
https://doi.org/10.1124/jpet.109.159103
Publikováno v:
Toxicology and Applied Pharmacology. 238:11-19
Cyanide is a potent inhibitor of mitochondrial oxidative metabolism and produces mitochondria-mediated death of dopaminergic neurons and sublethal intoxications that are associated with a Parkinson-like syndrome. Cyanide toxicity is enhanced when mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64980c32d036445d38bd8da5136c22b4
https://doi.org/10.1016/j.taap.2009.03.020
https://doi.org/10.1016/j.taap.2009.03.020
Publikováno v:
Neuroscience. 150:159-167
Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3), a Bcl-2 homology domain 3 (BH3) domain only protein, has been identified as a mitochondrial mediator of hypoxia-induced cell death. Since cyanide produces histotoxic anoxia (chemical hypoxia)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa64e2ee11d9bcc0c341a9028da8f6cb
https://doi.org/10.1016/j.neuroscience.2007.07.033
https://doi.org/10.1016/j.neuroscience.2007.07.033
Publikováno v:
Toxicological Sciences. 101:101-111
Acute cyanide toxicity is attributed to inhibition of cytochrome c oxidase (CcOX), the oxygen-reducing component of mitochondrial electron transport; however, the mitochondrial action of cyanide is complex and not completely understood. State-3 oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825b65886e59b0698b18e7455da4a335
https://doi.org/10.1093/toxsci/kfm254
https://doi.org/10.1093/toxsci/kfm254
Autor:
Gary E. Isom, Joseph L. Borowitz, L. Zhang, X. Zhang, K. Prabhakaran, L. Li, Heather B. Leavesley
Publikováno v:
Toxicology and Applied Pharmacology. 223:10-19
Uncoupling protein 2 (UCP-2) is an inner mitochondrial membrane proton carrier that modulates mitochondrial membrane potential (DeltaPsi(m)) and uncouples oxidative phosphorylation. We have shown that up-regulation of UCP-2 by Wy14,643, a selective p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8272dfe51dcf2a9d8af3e385c8b2ed9
https://doi.org/10.1016/j.taap.2007.05.002
https://doi.org/10.1016/j.taap.2007.05.002
Publikováno v:
Toxicology of Cyanides and Cyanogens: Experimental, applied and clinical aspects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::207ad4ae29cb3fef28e622d23bfcb7df
https://doi.org/10.1002/9781118628966
https://doi.org/10.1002/9781118628966