Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Gary E. Duncan"'
Publikováno v:
Brain Research. 1443:98-105
The pathophysiology of schizophrenia may involve reduced NMDA receptor function. Accordingly, experimental models of NMDA receptor hypofunction may be useful for testing potential new antipsychotic agents and for characterizing neurobiological abnorm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f4b7b3394c5a89a4843cb99eb99a01
https://doi.org/10.1016/j.brainres.2012.01.009
https://doi.org/10.1016/j.brainres.2012.01.009
Publikováno v:
Journal of Neural Transmission. 114:899-908
Induction of Fos protein by the potent and direct NMDA agonist (tetrazol-5-yl)glycine (TZG) was examined in mice. Effects of antipsychotic drugs were assessed on this in vivo index of NMDA receptor activation. TZG induced the expression of Fos in a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6292e1ba6b034849436bfa8d769e04bd
https://doi.org/10.1007/s00702-007-0628-5
https://doi.org/10.1007/s00702-007-0628-5
Publikováno v:
Pharmacology Biochemistry and Behavior. 85:481-491
Psychotomimetic effects of NMDA antagonists in humans suggest that NMDA receptor hypofunction could contribute to the pathophysiology of schizophrenia. A mouse line that expresses low levels of the NMDA R1 subunit (NR1) of the NMDA receptor was gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cc481b9d0415f510846cb466c6711b
https://doi.org/10.1016/j.pbb.2006.09.017
https://doi.org/10.1016/j.pbb.2006.09.017
Autor:
Lawrence J. Shampine, Marian I. Butterfield, Mark W. Massing, A. Leslie Morrow, Christine E. Marx, Jeffrey A. Lieberman, A. Chistina Grobin, Roger D. Madison, Margaret J. VanDoren, Gary E. Duncan, Daniel W. Bradford
Publikováno v:
Pharmacology Biochemistry and Behavior. 84:598-608
Clozapine demonstrates superior efficacy in patients with schizophrenia, but the precise mechanisms contributing to this clinical advantage are not clear. Clozapine and olanzapine increase the GABAergic neuroactive steroid (NS) allopregnanolone, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d90444fa92cdf252d65887ac65d20cb
https://doi.org/10.1016/j.pbb.2006.07.026
https://doi.org/10.1016/j.pbb.2006.07.026
Autor:
Beverly H. Koller, Sheryl S. Moy, John N. Snouwaert, Gary E. Duncan, Jeffrey A. Lieberman, Seiya Miyamoto
Publikováno v:
Neuropsychopharmacology. 29:2180-2188
A mouse strain has been developed that expresses low levels of the NR1 subunit of the NMDA receptor. These mice are a model of chronic developmental NMDA receptor hypofunction and may therefore have relevance to the hypothesized NMDA receptor hypofun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b94fdddf456b4eedcfc59ff9d9819db
https://doi.org/10.1038/sj.npp.1300548
https://doi.org/10.1038/sj.npp.1300548
Publikováno v:
Molecular Psychiatry. 10:79-104
The treatment of schizophrenia has evolved over the past half century primarily in the context of antipsychotic drug development. Although there has been significant progress resulting in the availability and use of numerous medications, these reflec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d121e53c4e4882c5bc016fa4a2bea0
https://doi.org/10.1038/sj.mp.4001556
https://doi.org/10.1038/sj.mp.4001556
Autor:
Gary E. Duncan, Wendy M Zinzow, Antonio Perez, Jeffrey A. Lieberman, Sheryl S. Moy, Dawn M Eddy, John N. Snouwaert, Beverly H. Koller
Publikováno v:
Behavioural Brain Research. 153:507-519
Reduced NMDA receptor function is hypothesized to contribute to the pathophysiology of schizophrenia. In order to model chronic and developmental NMDA receptor hypofunction, a mouse line was developed that expresses low levels of the NMDA R1 subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0506173dd4679f5604414880f9cad7
https://doi.org/10.1016/j.bbr.2004.01.008
https://doi.org/10.1016/j.bbr.2004.01.008
Autor:
George R. Breese, Fulton T. Crews, Ying Qian, Gary E. Duncan, Darin J. Knapp, Alda Fernandes, Christopher J. Braun
Publikováno v:
Alcoholism: Clinical and Experimental Research. 25:1662-1672
Background: Inhibition of NMDA receptor function in brain is believed to be an important action of ethanol (EtOH). To investigate EtOH inhibition of NMDA receptor responses in vivo, the interaction of these agents in brain after different routes of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::023ddc04efa04771833bb6071707408c
https://doi.org/10.1111/j.1530-0277.2001.tb02173.x
https://doi.org/10.1111/j.1530-0277.2001.tb02173.x
Publikováno v:
Brain Research. 843:171-183
Subanesthetic doses of NMDA receptor antagonists induce positive, negative and cognitive schizophrenia-like symptoms in healthy humans and precipitate psychotic reactions in stabilized schizophrenic patients. These findings suggest that defining neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bbc03fad4a2309843b82e038805ab2
https://doi.org/10.1016/s0006-8993(99)01776-x
https://doi.org/10.1016/s0006-8993(99)01776-x
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1485-1492
Previous research has suggested that rats tested at 28 to 30 days of age show a marked subsensitivity to the sedative effects of ethanol. In the present study, rats of different ages were tested for aerial righting following acute ethanol (3 g/kg) tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fad327cb7ad54cbe912be69cb611b5cf
https://doi.org/10.1111/j.1530-0277.1998.tb03940.x
https://doi.org/10.1111/j.1530-0277.1998.tb03940.x