Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Gary E Gorbet"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007942 (2020)
Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, stringent requirements nee
Externí odkaz:
https://doaj.org/article/cf83a3dd75d84f9491b269182f2a1ccf
Autor:
Amy Henrickson, Gary E. Gorbet, Alexey Savelyev, Minji Kim, Sarah K. Schultz, Xiaozhe Ding, Jason Hargreaves, Viviana Gradinaru, Ute Kothe, Borries Demeler
Multi-wavelength analytical ultracentrifugation (MW-AUC) is a recent development made possible by new analytical ultracentrifuge optical systems. MW-AUC is suitable for a wide range of applications and biopolymer systems and is poised to become an es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23024054ba929958268dc92efac648c
https://doi.org/10.21203/rs.3.rs-1184379/v1
https://doi.org/10.21203/rs.3.rs-1184379/v1
Autor:
Amy Henrickson, Gary E. Gorbet, Alexey Savelyev, Minji Kim, Jason Hargreaves, Sarah K. Schultz, Ute Kothe, Borries Demeler
Publikováno v:
Analytical Biochemistry. 652:114728
Multi-wavelength analytical ultracentrifugation (MW-AUC) is a recent development made possible by new analytical ultracentrifuge optical systems. MW-AUC extends the basic hydrodynamic information content of AUC and provides access to a wide range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2bfc5083834df98da1da25c9d03348
https://doi.org/10.1016/j.ab.2022.114728
https://doi.org/10.1016/j.ab.2022.114728
Autor:
Gary E. Gorbet, Borries Demeler, Amy Henrickson, Jayesh A. Kulkarni, Josh Zaifman, Pieter R. Cullis
Publikováno v:
ACS nano. 15(3)
Previous work suggested that lipid nanoparticle (LNP) formulations, encapsulating nucleic acids, display electron-dense morphology when examined by cryogenic-transmission electron microscopy (cryo-TEM). Critically, the employed cryo-TEM method cannot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a038767ed61beed656778ee9339b3e
https://pubmed.ncbi.nlm.nih.gov/33617224
https://pubmed.ncbi.nlm.nih.gov/33617224
Publikováno v:
European Biophysics Journal. 47:815-823
Recent developments in the UltraScan-III software make it possible to model multi-speed analytical ultracentrifugation sedimentation velocity experiments using finite element solutions of the Lamm equation. Using simulated data, we demonstrate here h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8e7fd3888bdce1a79dd9f3ffda4eb1
https://doi.org/10.1007/s00249-018-1308-0
https://doi.org/10.1007/s00249-018-1308-0
Publikováno v:
European Biophysics Journal. 47:825-835
A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space-time finite element fitting methods implemented in UltraScan-III to model s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d1e84a997e7460868bf36b26230bf3
https://doi.org/10.1007/s00249-018-1297-z
https://doi.org/10.1007/s00249-018-1297-z
Autor:
Jin Zhang, Gary E. Gorbet, Margo A. Brinton, Joseph Pearson, Helmut Cölfen, Markus W. Germann, Borries Demeler
Publikováno v:
Analytical Chemistry. 89:862-870
Interactions between nucleic acids and proteins are critical for many cellular processes, and their study is of utmost importance to many areas of biochemistry, cellular biology, and virology. Here, we introduce a new analytical method based on sedim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e154009030a557d3f500c3a04816b98
https://doi.org/10.1021/acs.analchem.6b03926
https://doi.org/10.1021/acs.analchem.6b03926
Autor:
Borries Demeler, Courtney N. Johnson, Gary E. Gorbet, Lorenzo Brancaleon, Heidi Ramsower, Julio Uriquidi
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86b1e88f82d625a19c1b27ef128c14b
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb83
https://doi.org/10.1096/fasebj.2018.32.1_supplement.lb83
Autor:
N. Attig, Borries Demeler, Gary E. Gorbet, Shahbaz Memon, Thomas Lippert, Lahiru Gunathilake, Andrew S. Grimshaw, Morris Riedel, Florian Janetzko, Raminder Singh, Suresh Marru
Publikováno v:
Concurrency and Computation: Practice and Experience. 26:2280-2291
The UltraScan data analysis application is a software package that is able to take advantage of computational resources in order to support the interpretation of analytical ultracentrifugation experiments. Since 2006, the UltraScan scientific gateway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77606d9d8b27ccdee7f3d3344314de4c
https://doi.org/10.1002/cpe.3251
https://doi.org/10.1002/cpe.3251
Autor:
Gary E. Gorbet, Borries Demeler
Publikováno v:
Analytical Ultracentrifugation ISBN: 9784431559832
The current status of the UltraScan-III (US3) data analysis software suite is described. An overview of the US3 concepts, software layout, the data workflows and US3 components is presented, followed by a discussion of the analysis methods and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b52f5d15c8426f67675ce36a5f4ef966
https://doi.org/10.1007/978-4-431-55985-6_8
https://doi.org/10.1007/978-4-431-55985-6_8